"RAPID AND SIMULTANEOUS DETERMINATION OF ADRIAMYCIN, BLEOMYCIN, VINBLASTINE AND DACARBAZINE IN PLASMA OF HODGKIN'S LYMPHOMA PATIENTS BY A REVERSED PHASE HPLC METHOD"

The RP-HPLC analytical method with UV detection at 230nm with ODS Hypersil C18 column (250mm x 4.6mm, 5µ particle size) was developed for simultaneous determination of Adriamycin, Bleomycin, Vinblastine and Dacarbazine in plasma of lymphoma patients using mobile phase composition of 300 volumes Acet...

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Autores principales:	ZUBAIR MALIK,MUHAMMAD, AHMAD,MAHMOOD, MUAHAMMAD,SALEH
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2013
Materias:	HPLC DOX Bleomycin Vinblastine Dacarbazine Hodgkin's Lymphoma
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200006
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id	oai:scielo:S0717-97072013000200006
record_format	dspace
spelling	oai:scielo:S0717-970720130002000062014-09-09"RAPID AND SIMULTANEOUS DETERMINATION OF ADRIAMYCIN, BLEOMYCIN, VINBLASTINE AND DACARBAZINE IN PLASMA OF HODGKIN'S LYMPHOMA PATIENTS BY A REVERSED PHASE HPLC METHOD"ZUBAIR MALIK,MUHAMMADAHMAD,MAHMOODMUAHAMMAD,SALEH HPLC DOX Bleomycin Vinblastine Dacarbazine Hodgkin's Lymphoma The RP-HPLC analytical method with UV detection at 230nm with ODS Hypersil C18 column (250mm x 4.6mm, 5µ particle size) was developed for simultaneous determination of Adriamycin, Bleomycin, Vinblastine and Dacarbazine in plasma of lymphoma patients using mobile phase composition of 300 volumes Acetonitrile and 700 volumes 0.05M Disodium Hydrogen Phosphate containing 0.5ml TEA and pH of the mobiles phase was maintained at 3.7 with 2M Phosphoric acid at a flow rate of 0.75ml/minute with linearity ranges of 0.05-50, 0.06-50, 0.075-50 and 0.09-50 µg/ml respectively with LOD and LOQ of 0.020, 0.050; 0.045, 0.060; 0.060, 0.075 and 0.040, 0.090 respectively. % recovery of DOX, BLM, VBL and DTIC were 99.24, 99.23, 99.08 and 99.09 respectively.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.2 20132013-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200006en10.4067/S0717-97072013000200006
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	HPLC DOX Bleomycin Vinblastine Dacarbazine Hodgkin's Lymphoma
spellingShingle	HPLC DOX Bleomycin Vinblastine Dacarbazine Hodgkin's Lymphoma ZUBAIR MALIK,MUHAMMAD AHMAD,MAHMOOD MUAHAMMAD,SALEH "RAPID AND SIMULTANEOUS DETERMINATION OF ADRIAMYCIN, BLEOMYCIN, VINBLASTINE AND DACARBAZINE IN PLASMA OF HODGKIN'S LYMPHOMA PATIENTS BY A REVERSED PHASE HPLC METHOD"
description	The RP-HPLC analytical method with UV detection at 230nm with ODS Hypersil C18 column (250mm x 4.6mm, 5µ particle size) was developed for simultaneous determination of Adriamycin, Bleomycin, Vinblastine and Dacarbazine in plasma of lymphoma patients using mobile phase composition of 300 volumes Acetonitrile and 700 volumes 0.05M Disodium Hydrogen Phosphate containing 0.5ml TEA and pH of the mobiles phase was maintained at 3.7 with 2M Phosphoric acid at a flow rate of 0.75ml/minute with linearity ranges of 0.05-50, 0.06-50, 0.075-50 and 0.09-50 µg/ml respectively with LOD and LOQ of 0.020, 0.050; 0.045, 0.060; 0.060, 0.075 and 0.040, 0.090 respectively. % recovery of DOX, BLM, VBL and DTIC were 99.24, 99.23, 99.08 and 99.09 respectively.
author	ZUBAIR MALIK,MUHAMMAD AHMAD,MAHMOOD MUAHAMMAD,SALEH
author_facet	ZUBAIR MALIK,MUHAMMAD AHMAD,MAHMOOD MUAHAMMAD,SALEH
author_sort	ZUBAIR MALIK,MUHAMMAD
title	"RAPID AND SIMULTANEOUS DETERMINATION OF ADRIAMYCIN, BLEOMYCIN, VINBLASTINE AND DACARBAZINE IN PLASMA OF HODGKIN'S LYMPHOMA PATIENTS BY A REVERSED PHASE HPLC METHOD"
title_short	"RAPID AND SIMULTANEOUS DETERMINATION OF ADRIAMYCIN, BLEOMYCIN, VINBLASTINE AND DACARBAZINE IN PLASMA OF HODGKIN'S LYMPHOMA PATIENTS BY A REVERSED PHASE HPLC METHOD"
title_full	"RAPID AND SIMULTANEOUS DETERMINATION OF ADRIAMYCIN, BLEOMYCIN, VINBLASTINE AND DACARBAZINE IN PLASMA OF HODGKIN'S LYMPHOMA PATIENTS BY A REVERSED PHASE HPLC METHOD"
title_fullStr	"RAPID AND SIMULTANEOUS DETERMINATION OF ADRIAMYCIN, BLEOMYCIN, VINBLASTINE AND DACARBAZINE IN PLASMA OF HODGKIN'S LYMPHOMA PATIENTS BY A REVERSED PHASE HPLC METHOD"
title_full_unstemmed	"RAPID AND SIMULTANEOUS DETERMINATION OF ADRIAMYCIN, BLEOMYCIN, VINBLASTINE AND DACARBAZINE IN PLASMA OF HODGKIN'S LYMPHOMA PATIENTS BY A REVERSED PHASE HPLC METHOD"
title_sort	"rapid and simultaneous determination of adriamycin, bleomycin, vinblastine and dacarbazine in plasma of hodgkin's lymphoma patients by a reversed phase hplc method"
publisher	Sociedad Chilena de Química
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200006
work_keys_str_mv	AT zubairmalikmuhammad rapidandsimultaneousdeterminationofadriamycinbleomycinvinblastineanddacarbazineinplasmaofhodgkinslymphomapatientsbyareversedphasehplcmethod AT ahmadmahmood rapidandsimultaneousdeterminationofadriamycinbleomycinvinblastineanddacarbazineinplasmaofhodgkinslymphomapatientsbyareversedphasehplcmethod AT muahammadsaleh rapidandsimultaneousdeterminationofadriamycinbleomycinvinblastineanddacarbazineinplasmaofhodgkinslymphomapatientsbyareversedphasehplcmethod
_version_	1718445485474185216

"RAPID AND SIMULTANEOUS DETERMINATION OF ADRIAMYCIN, BLEOMYCIN, VINBLASTINE AND DACARBAZINE IN PLASMA OF HODGKIN'S LYMPHOMA PATIENTS BY A REVERSED PHASE HPLC METHOD"

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