SYNTHESIS AND LEISHMANICIDAL ACTIVITY OF NEW BIS-ALKYLQUINOLINES

Bis-alkylquinolines 1-6 were synthetized via Williamson reaction between 8-hydroxyquinaldine with different É, ù-dihaloalkanes. Structures of all the products were elucidated by spectroscopic analysis. Cytotoxic and antileishmanial activities of synthesized compounds were determinated on U-937 cells...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	CARDONA,WILSON, ARANGO,VICTOR, DOMÍNGUEZ,JORGE J, ROBLEDO,SARA M, MUÑOZ,DIANA L, FIGADERE,BRUNO, VELEZ,IVAN D, SÁEZ,JAIRO
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2013
Materias:	Leishmania antiprotozoal quinoline
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200014
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-97072013000200014
record_format	dspace
spelling	oai:scielo:S0717-970720130002000142014-09-09SYNTHESIS AND LEISHMANICIDAL ACTIVITY OF NEW BIS-ALKYLQUINOLINESCARDONA,WILSONARANGO,VICTORDOMÍNGUEZ,JORGE JROBLEDO,SARA MMUÑOZ,DIANA LFIGADERE,BRUNOVELEZ,IVAN DSÁEZ,JAIRO Leishmania antiprotozoal quinoline Bis-alkylquinolines 1-6 were synthetized via Williamson reaction between 8-hydroxyquinaldine with different É, ù-dihaloalkanes. Structures of all the products were elucidated by spectroscopic analysis. Cytotoxic and antileishmanial activities of synthesized compounds were determinated on U-937 cells and L. (V) panamensis amastigotes, respectively. Compound 5, 1,9-bis[(2-methylquinolin-8-yl)oxy]nonane, was the most selective against axenic and intracellular amastigotes (EC50 = 11.3 and 22.6, ìg/mL), with selectivity indices greater than 17.7 and 8.8, respectively; which makes this compound promising for the developing of new leishmanicidal drugs.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.2 20132013-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200014en10.4067/S0717-97072013000200014
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Leishmania antiprotozoal quinoline
spellingShingle	Leishmania antiprotozoal quinoline CARDONA,WILSON ARANGO,VICTOR DOMÍNGUEZ,JORGE J ROBLEDO,SARA M MUÑOZ,DIANA L FIGADERE,BRUNO VELEZ,IVAN D SÁEZ,JAIRO SYNTHESIS AND LEISHMANICIDAL ACTIVITY OF NEW BIS-ALKYLQUINOLINES
description	Bis-alkylquinolines 1-6 were synthetized via Williamson reaction between 8-hydroxyquinaldine with different É, ù-dihaloalkanes. Structures of all the products were elucidated by spectroscopic analysis. Cytotoxic and antileishmanial activities of synthesized compounds were determinated on U-937 cells and L. (V) panamensis amastigotes, respectively. Compound 5, 1,9-bis[(2-methylquinolin-8-yl)oxy]nonane, was the most selective against axenic and intracellular amastigotes (EC50 = 11.3 and 22.6, ìg/mL), with selectivity indices greater than 17.7 and 8.8, respectively; which makes this compound promising for the developing of new leishmanicidal drugs.
author	CARDONA,WILSON ARANGO,VICTOR DOMÍNGUEZ,JORGE J ROBLEDO,SARA M MUÑOZ,DIANA L FIGADERE,BRUNO VELEZ,IVAN D SÁEZ,JAIRO
author_facet	CARDONA,WILSON ARANGO,VICTOR DOMÍNGUEZ,JORGE J ROBLEDO,SARA M MUÑOZ,DIANA L FIGADERE,BRUNO VELEZ,IVAN D SÁEZ,JAIRO
author_sort	CARDONA,WILSON
title	SYNTHESIS AND LEISHMANICIDAL ACTIVITY OF NEW BIS-ALKYLQUINOLINES
title_short	SYNTHESIS AND LEISHMANICIDAL ACTIVITY OF NEW BIS-ALKYLQUINOLINES
title_full	SYNTHESIS AND LEISHMANICIDAL ACTIVITY OF NEW BIS-ALKYLQUINOLINES
title_fullStr	SYNTHESIS AND LEISHMANICIDAL ACTIVITY OF NEW BIS-ALKYLQUINOLINES
title_full_unstemmed	SYNTHESIS AND LEISHMANICIDAL ACTIVITY OF NEW BIS-ALKYLQUINOLINES
title_sort	synthesis and leishmanicidal activity of new bis-alkylquinolines
publisher	Sociedad Chilena de Química
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200014
work_keys_str_mv	AT cardonawilson synthesisandleishmanicidalactivityofnewbisalkylquinolines AT arangovictor synthesisandleishmanicidalactivityofnewbisalkylquinolines AT dominguezjorgej synthesisandleishmanicidalactivityofnewbisalkylquinolines AT robledosaram synthesisandleishmanicidalactivityofnewbisalkylquinolines AT munozdianal synthesisandleishmanicidalactivityofnewbisalkylquinolines AT figaderebruno synthesisandleishmanicidalactivityofnewbisalkylquinolines AT velezivand synthesisandleishmanicidalactivityofnewbisalkylquinolines AT saezjairo synthesisandleishmanicidalactivityofnewbisalkylquinolines
_version_	1718445486817411072

SYNTHESIS AND LEISHMANICIDAL ACTIVITY OF NEW BIS-ALKYLQUINOLINES

Ejemplares similares