FORENSIC CASES IN THE NORTH OF CHILE: DETERMINATION OF ANTIDEPRESSANT DRUGS IN HUMAN WHOLE BLOOD

The consumption of antidepressant drugs has increased in these last years, leading to severe and lethal poisonings. In this work, analytical tools, namely GC/MSD and GC/NPD µECD, were used to identify and quantify several antidepressant drugs including amitriptyline, imipramine, sertraline, fluoxeti...

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Autores principales:	BRAVO,FELIPE, ZAMBRA,CARMEN, VENEGAS,KARINA, RIOS,DAVID, BUC CALDERON,PEDRO, BENITES,JULIO
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2013
Materias:	antidepressants gas chromatography mass selective detector ì-electron capture detector solid-phase extraction
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200020
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spelling	oai:scielo:S0717-970720130002000202014-09-09FORENSIC CASES IN THE NORTH OF CHILE: DETERMINATION OF ANTIDEPRESSANT DRUGS IN HUMAN WHOLE BLOODBRAVO,FELIPEZAMBRA,CARMENVENEGAS,KARINARIOS,DAVIDBUC CALDERON,PEDROBENITES,JULIO antidepressants gas chromatography mass selective detector ì-electron capture detector solid-phase extraction The consumption of antidepressant drugs has increased in these last years, leading to severe and lethal poisonings. In this work, analytical tools, namely GC/MSD and GC/NPD µECD, were used to identify and quantify several antidepressant drugs including amitriptyline, imipramine, sertraline, fluoxetine, and citalopram in forensic cases in the North of Chile during 2008-2011. Drugs were analyzed in biological arrays like blood. A solid phase extraction by Bond Elut Certify columns was applied in all these processes. Fluoxetine and sertraline were derivatized with pentafluoropropionic anhydride. Prazepam was used as internal standard (IS). The limit of detection (LOD) in blood were 0.5 - 20.07 ng/mL. The average extraction rate was 89.39% in blood. The relative standard deviation (RSD) was less than 3.6%, while the intra-day accuracy was < 5.5% and the inter-day was < 2.4%, referred to RSD. The procedures we have developed allow the quantification of drugs even at low therapeutic doses, a very important issue taking into account the nature of the analyzed arrays.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.2 20132013-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200020en10.4067/S0717-97072013000200020
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	antidepressants gas chromatography mass selective detector ì-electron capture detector solid-phase extraction
spellingShingle	antidepressants gas chromatography mass selective detector ì-electron capture detector solid-phase extraction BRAVO,FELIPE ZAMBRA,CARMEN VENEGAS,KARINA RIOS,DAVID BUC CALDERON,PEDRO BENITES,JULIO FORENSIC CASES IN THE NORTH OF CHILE: DETERMINATION OF ANTIDEPRESSANT DRUGS IN HUMAN WHOLE BLOOD
description	The consumption of antidepressant drugs has increased in these last years, leading to severe and lethal poisonings. In this work, analytical tools, namely GC/MSD and GC/NPD µECD, were used to identify and quantify several antidepressant drugs including amitriptyline, imipramine, sertraline, fluoxetine, and citalopram in forensic cases in the North of Chile during 2008-2011. Drugs were analyzed in biological arrays like blood. A solid phase extraction by Bond Elut Certify columns was applied in all these processes. Fluoxetine and sertraline were derivatized with pentafluoropropionic anhydride. Prazepam was used as internal standard (IS). The limit of detection (LOD) in blood were 0.5 - 20.07 ng/mL. The average extraction rate was 89.39% in blood. The relative standard deviation (RSD) was less than 3.6%, while the intra-day accuracy was < 5.5% and the inter-day was < 2.4%, referred to RSD. The procedures we have developed allow the quantification of drugs even at low therapeutic doses, a very important issue taking into account the nature of the analyzed arrays.
author	BRAVO,FELIPE ZAMBRA,CARMEN VENEGAS,KARINA RIOS,DAVID BUC CALDERON,PEDRO BENITES,JULIO
author_facet	BRAVO,FELIPE ZAMBRA,CARMEN VENEGAS,KARINA RIOS,DAVID BUC CALDERON,PEDRO BENITES,JULIO
author_sort	BRAVO,FELIPE
title	FORENSIC CASES IN THE NORTH OF CHILE: DETERMINATION OF ANTIDEPRESSANT DRUGS IN HUMAN WHOLE BLOOD
title_short	FORENSIC CASES IN THE NORTH OF CHILE: DETERMINATION OF ANTIDEPRESSANT DRUGS IN HUMAN WHOLE BLOOD
title_full	FORENSIC CASES IN THE NORTH OF CHILE: DETERMINATION OF ANTIDEPRESSANT DRUGS IN HUMAN WHOLE BLOOD
title_fullStr	FORENSIC CASES IN THE NORTH OF CHILE: DETERMINATION OF ANTIDEPRESSANT DRUGS IN HUMAN WHOLE BLOOD
title_full_unstemmed	FORENSIC CASES IN THE NORTH OF CHILE: DETERMINATION OF ANTIDEPRESSANT DRUGS IN HUMAN WHOLE BLOOD
title_sort	forensic cases in the north of chile: determination of antidepressant drugs in human whole blood
publisher	Sociedad Chilena de Química
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200020
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FORENSIC CASES IN THE NORTH OF CHILE: DETERMINATION OF ANTIDEPRESSANT DRUGS IN HUMAN WHOLE BLOOD

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