A STABILITY- INDICATING HPTLC METHOD FOR QUANTIFICATION OF ENALAPRIL MALEATE IN TABLETS

A stability- indicating high performance thin layer chromatographic (HPTLC) method was developed and validated for the determination of enalapril maleate in tablets. Chromatographic separation was achieved on precoated silica gel F 254 HPTLC plates using a mixture of 1-buthanol, glacial acetic acid...

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Autores principales:	MENNICKENT,SIGRID C, RIVAS,CRISTIAN, VEGA,MARIO A, DE DIEGO,MARTA G
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2013
Materias:	enalapril stability- indicating method HPTLC tablets
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200021
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spelling	oai:scielo:S0717-970720130002000212014-09-09A STABILITY- INDICATING HPTLC METHOD FOR QUANTIFICATION OF ENALAPRIL MALEATE IN TABLETSMENNICKENT,SIGRID CRIVAS,CRISTIANVEGA,MARIO ADE DIEGO,MARTA G enalapril stability- indicating method HPTLC tablets A stability- indicating high performance thin layer chromatographic (HPTLC) method was developed and validated for the determination of enalapril maleate in tablets. Chromatographic separation was achieved on precoated silica gel F 254 HPTLC plates using a mixture of 1-buthanol, glacial acetic acid and water (12:3:5, v/v) as a mobile phase. Quantitative analysis was carried out at a wavelength of 207 nm. The method exhibitied an adequate linearity (r =0.998), selectivity, precision and accuracy. Enalapril was subjected to oxidative, hydrolytic, thermal and photolytic stress conditions, and was found degradation significantly in basic stress condition only, during the time of the study. The degradation products were well resolved from main peak, proving the stability-indicating power of the method. This method was successfully applied for quantitative analysis of enalapril maleate in tablets. Therefore, the method is suitable for quantitative determination and the stability studies of enalapril maleate in tablets.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.2 20132013-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200021en10.4067/S0717-97072013000200021
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	enalapril stability- indicating method HPTLC tablets
spellingShingle	enalapril stability- indicating method HPTLC tablets MENNICKENT,SIGRID C RIVAS,CRISTIAN VEGA,MARIO A DE DIEGO,MARTA G A STABILITY- INDICATING HPTLC METHOD FOR QUANTIFICATION OF ENALAPRIL MALEATE IN TABLETS
description	A stability- indicating high performance thin layer chromatographic (HPTLC) method was developed and validated for the determination of enalapril maleate in tablets. Chromatographic separation was achieved on precoated silica gel F 254 HPTLC plates using a mixture of 1-buthanol, glacial acetic acid and water (12:3:5, v/v) as a mobile phase. Quantitative analysis was carried out at a wavelength of 207 nm. The method exhibitied an adequate linearity (r =0.998), selectivity, precision and accuracy. Enalapril was subjected to oxidative, hydrolytic, thermal and photolytic stress conditions, and was found degradation significantly in basic stress condition only, during the time of the study. The degradation products were well resolved from main peak, proving the stability-indicating power of the method. This method was successfully applied for quantitative analysis of enalapril maleate in tablets. Therefore, the method is suitable for quantitative determination and the stability studies of enalapril maleate in tablets.
author	MENNICKENT,SIGRID C RIVAS,CRISTIAN VEGA,MARIO A DE DIEGO,MARTA G
author_facet	MENNICKENT,SIGRID C RIVAS,CRISTIAN VEGA,MARIO A DE DIEGO,MARTA G
author_sort	MENNICKENT,SIGRID C
title	A STABILITY- INDICATING HPTLC METHOD FOR QUANTIFICATION OF ENALAPRIL MALEATE IN TABLETS
title_short	A STABILITY- INDICATING HPTLC METHOD FOR QUANTIFICATION OF ENALAPRIL MALEATE IN TABLETS
title_full	A STABILITY- INDICATING HPTLC METHOD FOR QUANTIFICATION OF ENALAPRIL MALEATE IN TABLETS
title_fullStr	A STABILITY- INDICATING HPTLC METHOD FOR QUANTIFICATION OF ENALAPRIL MALEATE IN TABLETS
title_full_unstemmed	A STABILITY- INDICATING HPTLC METHOD FOR QUANTIFICATION OF ENALAPRIL MALEATE IN TABLETS
title_sort	stability- indicating hptlc method for quantification of enalapril maleate in tablets
publisher	Sociedad Chilena de Química
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200021
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A STABILITY- INDICATING HPTLC METHOD FOR QUANTIFICATION OF ENALAPRIL MALEATE IN TABLETS

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