LICHENS: MIGHT BE CONSIDERED AS A SOURCE OF GASTROPROTECTIVE MOLECULES?

Lichens are symbiotic relationship between fungi and algae or cyanobacteria. Secondary metabolites from lichens are known as lichen substances. We investigated depsidone and depside from lichens 1-6 in the context of their action to prevent gastric ulcer on the model of HCl/ethanol in mice for the f...

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Autores principales:	SEPULVEDA,BEATRIZ, CHAMY,MARIA CRISTINA, PIOVANO,MARISA, ARECHE,CARLOS
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2013
Materias:	Lichens depside depsidone gastric ulcer
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200024
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spelling	oai:scielo:S0717-970720130002000242014-09-09LICHENS: MIGHT BE CONSIDERED AS A SOURCE OF GASTROPROTECTIVE MOLECULES?SEPULVEDA,BEATRIZCHAMY,MARIA CRISTINAPIOVANO,MARISAARECHE,CARLOS Lichens depside depsidone gastric ulcer Lichens are symbiotic relationship between fungi and algae or cyanobacteria. Secondary metabolites from lichens are known as lichen substances. We investigated depsidone and depside from lichens 1-6 in the context of their action to prevent gastric ulcer on the model of HCl/ethanol in mice for the first time. Doses of 30 mg/kg of lichen substances 1-6 and positive control (lansoprazole) significantly diminished the lesion index compared with negative control (treated only with HCl/EtOH). Lobaric acid 1, atranorin 2 and psoromic acid 5 reduced the gastric lesions by 76%, 63% and 65%, while for variolaric acid 3, diffractaic acid 4 and perlatolic acid 6 their values were 32%, 14% and 45%, respectively. Our results suggest that lichens have potential as a suite of gastroprotective molecules.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.2 20132013-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200024en10.4067/S0717-97072013000200024
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Lichens depside depsidone gastric ulcer
spellingShingle	Lichens depside depsidone gastric ulcer SEPULVEDA,BEATRIZ CHAMY,MARIA CRISTINA PIOVANO,MARISA ARECHE,CARLOS LICHENS: MIGHT BE CONSIDERED AS A SOURCE OF GASTROPROTECTIVE MOLECULES?
description	Lichens are symbiotic relationship between fungi and algae or cyanobacteria. Secondary metabolites from lichens are known as lichen substances. We investigated depsidone and depside from lichens 1-6 in the context of their action to prevent gastric ulcer on the model of HCl/ethanol in mice for the first time. Doses of 30 mg/kg of lichen substances 1-6 and positive control (lansoprazole) significantly diminished the lesion index compared with negative control (treated only with HCl/EtOH). Lobaric acid 1, atranorin 2 and psoromic acid 5 reduced the gastric lesions by 76%, 63% and 65%, while for variolaric acid 3, diffractaic acid 4 and perlatolic acid 6 their values were 32%, 14% and 45%, respectively. Our results suggest that lichens have potential as a suite of gastroprotective molecules.
author	SEPULVEDA,BEATRIZ CHAMY,MARIA CRISTINA PIOVANO,MARISA ARECHE,CARLOS
author_facet	SEPULVEDA,BEATRIZ CHAMY,MARIA CRISTINA PIOVANO,MARISA ARECHE,CARLOS
author_sort	SEPULVEDA,BEATRIZ
title	LICHENS: MIGHT BE CONSIDERED AS A SOURCE OF GASTROPROTECTIVE MOLECULES?
title_short	LICHENS: MIGHT BE CONSIDERED AS A SOURCE OF GASTROPROTECTIVE MOLECULES?
title_full	LICHENS: MIGHT BE CONSIDERED AS A SOURCE OF GASTROPROTECTIVE MOLECULES?
title_fullStr	LICHENS: MIGHT BE CONSIDERED AS A SOURCE OF GASTROPROTECTIVE MOLECULES?
title_full_unstemmed	LICHENS: MIGHT BE CONSIDERED AS A SOURCE OF GASTROPROTECTIVE MOLECULES?
title_sort	lichens: might be considered as a source of gastroprotective molecules?
publisher	Sociedad Chilena de Química
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200024
work_keys_str_mv	AT sepulvedabeatriz lichensmightbeconsideredasasourceofgastroprotectivemolecules AT chamymariacristina lichensmightbeconsideredasasourceofgastroprotectivemolecules AT piovanomarisa lichensmightbeconsideredasasourceofgastroprotectivemolecules AT arechecarlos lichensmightbeconsideredasasourceofgastroprotectivemolecules
_version_	1718445488583213056

LICHENS: MIGHT BE CONSIDERED AS A SOURCE OF GASTROPROTECTIVE MOLECULES?

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