¹H AND 13C NMR SPECTRAL ASSIGNMENTS AND X-RAY CRYSTALLOGRAPHY OF N-(3-(1H-IMIDAZOL-1-YL)PROPYL)-2-PHENYLQUINAZOLIN-4-AMINE

¹H AND 13C NMR SPECTRAL ASSIGNMENTS AND X-RAY CRYSTALLOGRAPHY OF N-(3-(1H-IMIDAZOL-1-YL)PROPYL)-2-PHENYLQUINAZOLIN-4-AMINE

N-(3-(1H-Imidazol-1-yl)propyl)-2-phenylquinazolin-4-amine (2) was obtained by nucleophilic substitution of 1-(3-aminopropyl)-imidazole over 4-chloro-2-phenylquinazoline (1) with DMF/TEA at room temperature. The precursor and product were characterized by NMR spectroscopy. The structure of the title...

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Autores principales: PÉREZ-FEHRMANN,MARCIA, KESTERNICH,VICTOR, VERDUGO,FELIPE, MARCOURT,LAURENCE, CHRISTEN,PHILIPPE, BRITO,IVÁN
Lenguaje:English
Publicado: Sociedad Chilena de Química 2013
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200029
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spelling oai:scielo:S0717-970720130002000292014-09-09¹H AND 13C NMR SPECTRAL ASSIGNMENTS AND X-RAY CRYSTALLOGRAPHY OF N-(3-(1H-IMIDAZOL-1-YL)PROPYL)-2-PHENYLQUINAZOLIN-4-AMINEPÉREZ-FEHRMANN,MARCIAKESTERNICH,VICTORVERDUGO,FELIPEMARCOURT,LAURENCECHRISTEN,PHILIPPEBRITO,IVÁNN-(3-(1H-Imidazol-1-yl)propyl)-2-phenylquinazolin-4-amine (2) was obtained by nucleophilic substitution of 1-(3-aminopropyl)-imidazole over 4-chloro-2-phenylquinazoline (1) with DMF/TEA at room temperature. The precursor and product were characterized by NMR spectroscopy. The structure of the title compound was confirmed by X-ray diffraction methods. The quinazoline fragment (2) is essentially planar and makes a dihedral angle of 66.35 ° with the imidazole plane. In the crystal packing the molecules are associated by two strong intermolecular NH----N hydrogen bonds with graph-set motif R²2(16). These pairs are linked by two π-π interactions.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.2 20132013-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200029en10.4067/S0717-97072013000200029
institution Scielo Chile
collection Scielo Chile
language English
description N-(3-(1H-Imidazol-1-yl)propyl)-2-phenylquinazolin-4-amine (2) was obtained by nucleophilic substitution of 1-(3-aminopropyl)-imidazole over 4-chloro-2-phenylquinazoline (1) with DMF/TEA at room temperature. The precursor and product were characterized by NMR spectroscopy. The structure of the title compound was confirmed by X-ray diffraction methods. The quinazoline fragment (2) is essentially planar and makes a dihedral angle of 66.35 ° with the imidazole plane. In the crystal packing the molecules are associated by two strong intermolecular NH----N hydrogen bonds with graph-set motif R²2(16). These pairs are linked by two π-π interactions.
author PÉREZ-FEHRMANN,MARCIA
KESTERNICH,VICTOR
VERDUGO,FELIPE
MARCOURT,LAURENCE
CHRISTEN,PHILIPPE
BRITO,IVÁN
spellingShingle PÉREZ-FEHRMANN,MARCIA
KESTERNICH,VICTOR
VERDUGO,FELIPE
MARCOURT,LAURENCE
CHRISTEN,PHILIPPE
BRITO,IVÁN
¹H AND 13C NMR SPECTRAL ASSIGNMENTS AND X-RAY CRYSTALLOGRAPHY OF N-(3-(1H-IMIDAZOL-1-YL)PROPYL)-2-PHENYLQUINAZOLIN-4-AMINE
author_facet PÉREZ-FEHRMANN,MARCIA
KESTERNICH,VICTOR
VERDUGO,FELIPE
MARCOURT,LAURENCE
CHRISTEN,PHILIPPE
BRITO,IVÁN
author_sort PÉREZ-FEHRMANN,MARCIA
title ¹H AND 13C NMR SPECTRAL ASSIGNMENTS AND X-RAY CRYSTALLOGRAPHY OF N-(3-(1H-IMIDAZOL-1-YL)PROPYL)-2-PHENYLQUINAZOLIN-4-AMINE
title_short ¹H AND 13C NMR SPECTRAL ASSIGNMENTS AND X-RAY CRYSTALLOGRAPHY OF N-(3-(1H-IMIDAZOL-1-YL)PROPYL)-2-PHENYLQUINAZOLIN-4-AMINE
title_full ¹H AND 13C NMR SPECTRAL ASSIGNMENTS AND X-RAY CRYSTALLOGRAPHY OF N-(3-(1H-IMIDAZOL-1-YL)PROPYL)-2-PHENYLQUINAZOLIN-4-AMINE
title_fullStr ¹H AND 13C NMR SPECTRAL ASSIGNMENTS AND X-RAY CRYSTALLOGRAPHY OF N-(3-(1H-IMIDAZOL-1-YL)PROPYL)-2-PHENYLQUINAZOLIN-4-AMINE
title_full_unstemmed ¹H AND 13C NMR SPECTRAL ASSIGNMENTS AND X-RAY CRYSTALLOGRAPHY OF N-(3-(1H-IMIDAZOL-1-YL)PROPYL)-2-PHENYLQUINAZOLIN-4-AMINE
title_sort ¹h and 13c nmr spectral assignments and x-ray crystallography of n-(3-(1h-imidazol-1-yl)propyl)-2-phenylquinazolin-4-amine
publisher Sociedad Chilena de Química
publishDate 2013
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200029
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