PRELIMINARY ANTIPROLIFERATIVE EVALUATION OF NATURAL,-SYNTHETIC BENZALDEHYDES AND BENZYL ALCOHOLS

Vanillin, o-vanillin, natural and synthetic benzaldehydes and benzyl alcohols were assessed for antiproliferative effects using different human cell lines. Benzyl alcohols were synthesized from benzaldehydes reduced with NaBH4 in methanol solution. A new method for deprotection of ether compounds wi...

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Autores principales:	MADRID,ALEJANDRO, ESPINOZA,LUIS, CATALÁN,KAREN, GONZALEZ,CESAR, MONTENEGRO,IVÁN, MELLADO,MARCO, WERNER,ENRIQUE, CUELLAR,MAURICIO, VILLENA,JOAN
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2013
Materias:	Antiproliferative Benzaldehydes Benzyl Alcohols o-vainillin
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300003
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spelling	oai:scielo:S0717-970720130003000032014-09-09PRELIMINARY ANTIPROLIFERATIVE EVALUATION OF NATURAL,-SYNTHETIC BENZALDEHYDES AND BENZYL ALCOHOLSMADRID,ALEJANDROESPINOZA,LUISCATALÁN,KARENGONZALEZ,CESARMONTENEGRO,IVÁNMELLADO,MARCOWERNER,ENRIQUECUELLAR,MAURICIOVILLENA,JOAN Antiproliferative Benzaldehydes Benzyl Alcohols o-vainillin Vanillin, o-vanillin, natural and synthetic benzaldehydes and benzyl alcohols were assessed for antiproliferative effects using different human cell lines. Benzyl alcohols were synthesized from benzaldehydes reduced with NaBH4 in methanol solution. A new method for deprotection of ether compounds with TiCl4 solution was achieved with better performance, than previously reported. Twenty four compounds were tested. The in vitro growth inhibition assay was based on sulphorhodamine dye to quantify cell viability. Catechol 9 derived from piperonal as well as compounds 4 and 12 showed higher cytotoxicity on breast and prostate cancer cell lines (MDA-MB-231 and PC-3 respectively). o-Vanillin 5 has the highest cytotoxicity for all cell lines. IC50 values of 35.40 ± 4.2 μM Breast MDA-MB231; 47.10 ± 3.8 μM Prostate PC-3; 72.50 + 5.4 μM Prostate DU-145; 85.10 + 6.5 μM and Colon HT-29, were obtained without toxicity towards dermal human fibroblast (DHF cells).info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.3 20132013-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300003en10.4067/S0717-97072013000300003
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Antiproliferative Benzaldehydes Benzyl Alcohols o-vainillin
spellingShingle	Antiproliferative Benzaldehydes Benzyl Alcohols o-vainillin MADRID,ALEJANDRO ESPINOZA,LUIS CATALÁN,KAREN GONZALEZ,CESAR MONTENEGRO,IVÁN MELLADO,MARCO WERNER,ENRIQUE CUELLAR,MAURICIO VILLENA,JOAN PRELIMINARY ANTIPROLIFERATIVE EVALUATION OF NATURAL,-SYNTHETIC BENZALDEHYDES AND BENZYL ALCOHOLS
description	Vanillin, o-vanillin, natural and synthetic benzaldehydes and benzyl alcohols were assessed for antiproliferative effects using different human cell lines. Benzyl alcohols were synthesized from benzaldehydes reduced with NaBH4 in methanol solution. A new method for deprotection of ether compounds with TiCl4 solution was achieved with better performance, than previously reported. Twenty four compounds were tested. The in vitro growth inhibition assay was based on sulphorhodamine dye to quantify cell viability. Catechol 9 derived from piperonal as well as compounds 4 and 12 showed higher cytotoxicity on breast and prostate cancer cell lines (MDA-MB-231 and PC-3 respectively). o-Vanillin 5 has the highest cytotoxicity for all cell lines. IC50 values of 35.40 ± 4.2 μM Breast MDA-MB231; 47.10 ± 3.8 μM Prostate PC-3; 72.50 + 5.4 μM Prostate DU-145; 85.10 + 6.5 μM and Colon HT-29, were obtained without toxicity towards dermal human fibroblast (DHF cells).
author	MADRID,ALEJANDRO ESPINOZA,LUIS CATALÁN,KAREN GONZALEZ,CESAR MONTENEGRO,IVÁN MELLADO,MARCO WERNER,ENRIQUE CUELLAR,MAURICIO VILLENA,JOAN
author_facet	MADRID,ALEJANDRO ESPINOZA,LUIS CATALÁN,KAREN GONZALEZ,CESAR MONTENEGRO,IVÁN MELLADO,MARCO WERNER,ENRIQUE CUELLAR,MAURICIO VILLENA,JOAN
author_sort	MADRID,ALEJANDRO
title	PRELIMINARY ANTIPROLIFERATIVE EVALUATION OF NATURAL,-SYNTHETIC BENZALDEHYDES AND BENZYL ALCOHOLS
title_short	PRELIMINARY ANTIPROLIFERATIVE EVALUATION OF NATURAL,-SYNTHETIC BENZALDEHYDES AND BENZYL ALCOHOLS
title_full	PRELIMINARY ANTIPROLIFERATIVE EVALUATION OF NATURAL,-SYNTHETIC BENZALDEHYDES AND BENZYL ALCOHOLS
title_fullStr	PRELIMINARY ANTIPROLIFERATIVE EVALUATION OF NATURAL,-SYNTHETIC BENZALDEHYDES AND BENZYL ALCOHOLS
title_full_unstemmed	PRELIMINARY ANTIPROLIFERATIVE EVALUATION OF NATURAL,-SYNTHETIC BENZALDEHYDES AND BENZYL ALCOHOLS
title_sort	preliminary antiproliferative evaluation of natural,-synthetic benzaldehydes and benzyl alcohols
publisher	Sociedad Chilena de Química
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300003
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PRELIMINARY ANTIPROLIFERATIVE EVALUATION OF NATURAL,-SYNTHETIC BENZALDEHYDES AND BENZYL ALCOHOLS

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