CO-DETERMINATION OF TWO ANTIPARASITICS DRUGS BY DERIVATIVE SPECTROPHOTOMETRY AND ITS PHOTODEGRADATION STUDIES

This work proposes a method for the co-determination of praziquantel and fenbendazole in veterinary pharmaceutical formulations (VPF) by second-derivative spectrophotometry at 226.4 nm (Zero-crossing method) and 324.6 nm (Graphic method), respectively. The excipients commonly used in VPF do not inte...

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Autores principales:	SOTO,CÉSAR, OTIPKA,ROMINA, CONTRERAS,DAVID, YÁÑEZ,JORGE, TORAL,M. INÉS
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2013
Materias:	Fenbendazole Praziquantel Derivative Spectrophotometry Veterinary Formulations Photochemical Decomposition
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300006
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spelling	oai:scielo:S0717-970720130003000062014-09-09CO-DETERMINATION OF TWO ANTIPARASITICS DRUGS BY DERIVATIVE SPECTROPHOTOMETRY AND ITS PHOTODEGRADATION STUDIESSOTO,CÉSAROTIPKA,ROMINACONTRERAS,DAVIDYÁÑEZ,JORGETORAL,M. INÉS Fenbendazole Praziquantel Derivative Spectrophotometry Veterinary Formulations Photochemical Decomposition This work proposes a method for the co-determination of praziquantel and fenbendazole in veterinary pharmaceutical formulations (VPF) by second-derivative spectrophotometry at 226.4 nm (Zero-crossing method) and 324.6 nm (Graphic method), respectively. The excipients commonly used in VPF do not interfere. To obtain the optimal determination conditions, studies of solvent and light effects, were performed. The results of the light effects show that the expose of both drugs to indirect light and darkness does not produce any chemical change, since their zero-order spectra remained unchanged during the experiment. However, the exposition to the direct light only affects the fenbendazole. The zero order spectrum of FBZ in EtOH-HCl, present two broad bands (200 to 240 nm and 260 to 330 nm), these signals disappear and appear others totally different, at 230 nm and other with two peaks (285 and 295 nm). The FT-IR spectrum shows characteristics signals of the FBZ structure as the amide-NH group (3336.3 cm¹), this signal disappear indicating the bond break of the amide group caused by the exposition to sunlight for a time. These spectral changes evidenced a structural transformation as a result of photochemical decomposition in acid medium.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.3 20132013-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300006en10.4067/S0717-97072013000300006
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Fenbendazole Praziquantel Derivative Spectrophotometry Veterinary Formulations Photochemical Decomposition
spellingShingle	Fenbendazole Praziquantel Derivative Spectrophotometry Veterinary Formulations Photochemical Decomposition SOTO,CÉSAR OTIPKA,ROMINA CONTRERAS,DAVID YÁÑEZ,JORGE TORAL,M. INÉS CO-DETERMINATION OF TWO ANTIPARASITICS DRUGS BY DERIVATIVE SPECTROPHOTOMETRY AND ITS PHOTODEGRADATION STUDIES
description	This work proposes a method for the co-determination of praziquantel and fenbendazole in veterinary pharmaceutical formulations (VPF) by second-derivative spectrophotometry at 226.4 nm (Zero-crossing method) and 324.6 nm (Graphic method), respectively. The excipients commonly used in VPF do not interfere. To obtain the optimal determination conditions, studies of solvent and light effects, were performed. The results of the light effects show that the expose of both drugs to indirect light and darkness does not produce any chemical change, since their zero-order spectra remained unchanged during the experiment. However, the exposition to the direct light only affects the fenbendazole. The zero order spectrum of FBZ in EtOH-HCl, present two broad bands (200 to 240 nm and 260 to 330 nm), these signals disappear and appear others totally different, at 230 nm and other with two peaks (285 and 295 nm). The FT-IR spectrum shows characteristics signals of the FBZ structure as the amide-NH group (3336.3 cm¹), this signal disappear indicating the bond break of the amide group caused by the exposition to sunlight for a time. These spectral changes evidenced a structural transformation as a result of photochemical decomposition in acid medium.
author	SOTO,CÉSAR OTIPKA,ROMINA CONTRERAS,DAVID YÁÑEZ,JORGE TORAL,M. INÉS
author_facet	SOTO,CÉSAR OTIPKA,ROMINA CONTRERAS,DAVID YÁÑEZ,JORGE TORAL,M. INÉS
author_sort	SOTO,CÉSAR
title	CO-DETERMINATION OF TWO ANTIPARASITICS DRUGS BY DERIVATIVE SPECTROPHOTOMETRY AND ITS PHOTODEGRADATION STUDIES
title_short	CO-DETERMINATION OF TWO ANTIPARASITICS DRUGS BY DERIVATIVE SPECTROPHOTOMETRY AND ITS PHOTODEGRADATION STUDIES
title_full	CO-DETERMINATION OF TWO ANTIPARASITICS DRUGS BY DERIVATIVE SPECTROPHOTOMETRY AND ITS PHOTODEGRADATION STUDIES
title_fullStr	CO-DETERMINATION OF TWO ANTIPARASITICS DRUGS BY DERIVATIVE SPECTROPHOTOMETRY AND ITS PHOTODEGRADATION STUDIES
title_full_unstemmed	CO-DETERMINATION OF TWO ANTIPARASITICS DRUGS BY DERIVATIVE SPECTROPHOTOMETRY AND ITS PHOTODEGRADATION STUDIES
title_sort	co-determination of two antiparasitics drugs by derivative spectrophotometry and its photodegradation studies
publisher	Sociedad Chilena de Química
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300006
work_keys_str_mv	AT sotocesar codeterminationoftwoantiparasiticsdrugsbyderivativespectrophotometryanditsphotodegradationstudies AT otipkaromina codeterminationoftwoantiparasiticsdrugsbyderivativespectrophotometryanditsphotodegradationstudies AT contrerasdavid codeterminationoftwoantiparasiticsdrugsbyderivativespectrophotometryanditsphotodegradationstudies AT yanezjorge codeterminationoftwoantiparasiticsdrugsbyderivativespectrophotometryanditsphotodegradationstudies AT toralmines codeterminationoftwoantiparasiticsdrugsbyderivativespectrophotometryanditsphotodegradationstudies
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CO-DETERMINATION OF TWO ANTIPARASITICS DRUGS BY DERIVATIVE SPECTROPHOTOMETRY AND ITS PHOTODEGRADATION STUDIES

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