SIMULTANEOUS ESTIMATION OF ESOMEPRAZOLE AND LEVOSULPIRIDE IN BULK AND IN CAPSULE FORMULATION BY RP-HPLC

The present work deals with development and validation for simultaneous determination of Esomeprazole and Levosulpiride drugs in pharmaceutical formulations. A rapid, precise and specific reverse phase high performance liquid chromatography (RP-HPLC) method was developed for Esomeprazole and Levosul...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	JAIN,RAKESHR, PATIL,PRAVINO, BARI,SANJAYB
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2013
Materias:	RP-HPLC Esomeprazole Levosulpiride Capsule Formulation Validation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300011
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-97072013000300011
record_format	dspace
spelling	oai:scielo:S0717-970720130003000112014-09-09SIMULTANEOUS ESTIMATION OF ESOMEPRAZOLE AND LEVOSULPIRIDE IN BULK AND IN CAPSULE FORMULATION BY RP-HPLCJAIN,RAKESHRPATIL,PRAVINOBARI,SANJAYB RP-HPLC Esomeprazole Levosulpiride Capsule Formulation Validation The present work deals with development and validation for simultaneous determination of Esomeprazole and Levosulpiride drugs in pharmaceutical formulations. A rapid, precise and specific reverse phase high performance liquid chromatography (RP-HPLC) method was developed for Esomeprazole and Levosulpiride. Chromatographic separations was achieved on a C-18 (5μm, 250x4.6 mm) HPLC column within a runtime of 10 min. Isocratic mobile phase contain methanol: buffer (pH 3) (65:35% v/v) and flow rate was maintained at 1.0 mL/min. Eluate was monitored at 260 nm. Levosulpiride was eluated at 2.7 min and Esomeprazole at 5.7 min. Linearity was studied in the concentratiosn range of 5 to 30 μg mL-1 and 10 to 60 μg/ mL for esomeprazole and levosulpiride respectively, with a correlation coefficient of 0.9995 and 0.9993 respectively. The method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.3 20132013-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300011en10.4067/S0717-97072013000300011
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	RP-HPLC Esomeprazole Levosulpiride Capsule Formulation Validation
spellingShingle	RP-HPLC Esomeprazole Levosulpiride Capsule Formulation Validation JAIN,RAKESHR PATIL,PRAVINO BARI,SANJAYB SIMULTANEOUS ESTIMATION OF ESOMEPRAZOLE AND LEVOSULPIRIDE IN BULK AND IN CAPSULE FORMULATION BY RP-HPLC
description	The present work deals with development and validation for simultaneous determination of Esomeprazole and Levosulpiride drugs in pharmaceutical formulations. A rapid, precise and specific reverse phase high performance liquid chromatography (RP-HPLC) method was developed for Esomeprazole and Levosulpiride. Chromatographic separations was achieved on a C-18 (5μm, 250x4.6 mm) HPLC column within a runtime of 10 min. Isocratic mobile phase contain methanol: buffer (pH 3) (65:35% v/v) and flow rate was maintained at 1.0 mL/min. Eluate was monitored at 260 nm. Levosulpiride was eluated at 2.7 min and Esomeprazole at 5.7 min. Linearity was studied in the concentratiosn range of 5 to 30 μg mL-1 and 10 to 60 μg/ mL for esomeprazole and levosulpiride respectively, with a correlation coefficient of 0.9995 and 0.9993 respectively. The method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness.
author	JAIN,RAKESHR PATIL,PRAVINO BARI,SANJAYB
author_facet	JAIN,RAKESHR PATIL,PRAVINO BARI,SANJAYB
author_sort	JAIN,RAKESHR
title	SIMULTANEOUS ESTIMATION OF ESOMEPRAZOLE AND LEVOSULPIRIDE IN BULK AND IN CAPSULE FORMULATION BY RP-HPLC
title_short	SIMULTANEOUS ESTIMATION OF ESOMEPRAZOLE AND LEVOSULPIRIDE IN BULK AND IN CAPSULE FORMULATION BY RP-HPLC
title_full	SIMULTANEOUS ESTIMATION OF ESOMEPRAZOLE AND LEVOSULPIRIDE IN BULK AND IN CAPSULE FORMULATION BY RP-HPLC
title_fullStr	SIMULTANEOUS ESTIMATION OF ESOMEPRAZOLE AND LEVOSULPIRIDE IN BULK AND IN CAPSULE FORMULATION BY RP-HPLC
title_full_unstemmed	SIMULTANEOUS ESTIMATION OF ESOMEPRAZOLE AND LEVOSULPIRIDE IN BULK AND IN CAPSULE FORMULATION BY RP-HPLC
title_sort	simultaneous estimation of esomeprazole and levosulpiride in bulk and in capsule formulation by rp-hplc
publisher	Sociedad Chilena de Química
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300011
work_keys_str_mv	AT jainrakeshr simultaneousestimationofesomeprazoleandlevosulpirideinbulkandincapsuleformulationbyrphplc AT patilpravino simultaneousestimationofesomeprazoleandlevosulpirideinbulkandincapsuleformulationbyrphplc AT barisanjayb simultaneousestimationofesomeprazoleandlevosulpirideinbulkandincapsuleformulationbyrphplc
_version_	1718445492683145216

SIMULTANEOUS ESTIMATION OF ESOMEPRAZOLE AND LEVOSULPIRIDE IN BULK AND IN CAPSULE FORMULATION BY RP-HPLC

Ejemplares similares