SYNTHESIS, X-RAY CRYSTALLOGRAPHY, MOLECULAR DOCKING AND BIOLOGICAL SCREENING OF 2-AMINOPHENOL BASED SCHIFF BASES
Schiff bases, 2-{[(2-hydroxyphenyl)methylidene]amino}phenol (4) and 2-{[3-4-(dimethylamino)phenyl-2-propenylidene]amino}phenol (5), have been synthesized by the condensation of 2-aminophenol (1) with 2-hydroxybenzaldehyde (2) and 4-dimethylaminocinnamaldehyde (3), respectively. They showed good lipo...
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Sociedad Chilena de Química
2013
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oai:scielo:S0717-970720130003000162014-09-09SYNTHESIS, X-RAY CRYSTALLOGRAPHY, MOLECULAR DOCKING AND BIOLOGICAL SCREENING OF 2-AMINOPHENOL BASED SCHIFF BASESASLAM,MUHAMMADANIS,ITRATAFZA,NIGHATHUSSAIN,MUHAMMAD TAHIRMEHMOOD,RASHADHUSSAIN,AJAZYOUSUF,SAMMERIQBAL,LUBNAIQBAL,SAMINAKHAN,INAMULLAH Schiff bases Synthesis X-ray diffraction Molecular docking Biological activities Schiff bases, 2-{[(2-hydroxyphenyl)methylidene]amino}phenol (4) and 2-{[3-4-(dimethylamino)phenyl-2-propenylidene]amino}phenol (5), have been synthesized by the condensation of 2-aminophenol (1) with 2-hydroxybenzaldehyde (2) and 4-dimethylaminocinnamaldehyde (3), respectively. They showed good lipoxygenase inhibition and antioxidant activities, as compound 4 showed potent antioxidant activity. The products also showed good activities against Gram-positive: S. intermedius, B. subtilis and S. aureus, and Gram-negative: E. coli and S. typhi bacteria, as compounds 5 and 4 are excellent active against B. subtilis and S. typhi, respectively. These good to potent activities may be due to the presence of free hydroxyl and amino groups. They showed non-significant urease inhibition activity.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.3 20132013-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300016en10.4067/S0717-97072013000300016 |
institution |
Scielo Chile |
collection |
Scielo Chile |
language |
English |
topic |
Schiff bases Synthesis X-ray diffraction Molecular docking Biological activities |
spellingShingle |
Schiff bases Synthesis X-ray diffraction Molecular docking Biological activities ASLAM,MUHAMMAD ANIS,ITRAT AFZA,NIGHAT HUSSAIN,MUHAMMAD TAHIR MEHMOOD,RASHAD HUSSAIN,AJAZ YOUSUF,SAMMER IQBAL,LUBNA IQBAL,SAMINA KHAN,INAMULLAH SYNTHESIS, X-RAY CRYSTALLOGRAPHY, MOLECULAR DOCKING AND BIOLOGICAL SCREENING OF 2-AMINOPHENOL BASED SCHIFF BASES |
description |
Schiff bases, 2-{[(2-hydroxyphenyl)methylidene]amino}phenol (4) and 2-{[3-4-(dimethylamino)phenyl-2-propenylidene]amino}phenol (5), have been synthesized by the condensation of 2-aminophenol (1) with 2-hydroxybenzaldehyde (2) and 4-dimethylaminocinnamaldehyde (3), respectively. They showed good lipoxygenase inhibition and antioxidant activities, as compound 4 showed potent antioxidant activity. The products also showed good activities against Gram-positive: S. intermedius, B. subtilis and S. aureus, and Gram-negative: E. coli and S. typhi bacteria, as compounds 5 and 4 are excellent active against B. subtilis and S. typhi, respectively. These good to potent activities may be due to the presence of free hydroxyl and amino groups. They showed non-significant urease inhibition activity. |
author |
ASLAM,MUHAMMAD ANIS,ITRAT AFZA,NIGHAT HUSSAIN,MUHAMMAD TAHIR MEHMOOD,RASHAD HUSSAIN,AJAZ YOUSUF,SAMMER IQBAL,LUBNA IQBAL,SAMINA KHAN,INAMULLAH |
author_facet |
ASLAM,MUHAMMAD ANIS,ITRAT AFZA,NIGHAT HUSSAIN,MUHAMMAD TAHIR MEHMOOD,RASHAD HUSSAIN,AJAZ YOUSUF,SAMMER IQBAL,LUBNA IQBAL,SAMINA KHAN,INAMULLAH |
author_sort |
ASLAM,MUHAMMAD |
title |
SYNTHESIS, X-RAY CRYSTALLOGRAPHY, MOLECULAR DOCKING AND BIOLOGICAL SCREENING OF 2-AMINOPHENOL BASED SCHIFF BASES |
title_short |
SYNTHESIS, X-RAY CRYSTALLOGRAPHY, MOLECULAR DOCKING AND BIOLOGICAL SCREENING OF 2-AMINOPHENOL BASED SCHIFF BASES |
title_full |
SYNTHESIS, X-RAY CRYSTALLOGRAPHY, MOLECULAR DOCKING AND BIOLOGICAL SCREENING OF 2-AMINOPHENOL BASED SCHIFF BASES |
title_fullStr |
SYNTHESIS, X-RAY CRYSTALLOGRAPHY, MOLECULAR DOCKING AND BIOLOGICAL SCREENING OF 2-AMINOPHENOL BASED SCHIFF BASES |
title_full_unstemmed |
SYNTHESIS, X-RAY CRYSTALLOGRAPHY, MOLECULAR DOCKING AND BIOLOGICAL SCREENING OF 2-AMINOPHENOL BASED SCHIFF BASES |
title_sort |
synthesis, x-ray crystallography, molecular docking and biological screening of 2-aminophenol based schiff bases |
publisher |
Sociedad Chilena de Química |
publishDate |
2013 |
url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300016 |
work_keys_str_mv |
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