SYNTHESIS, X-RAY CRYSTALLOGRAPHY, MOLECULAR DOCKING AND BIOLOGICAL SCREENING OF 2-AMINOPHENOL BASED SCHIFF BASES

Schiff bases, 2-{[(2-hydroxyphenyl)methylidene]amino}phenol (4) and 2-{[3-4-(dimethylamino)phenyl-2-propenylidene]amino}phenol (5), have been synthesized by the condensation of 2-aminophenol (1) with 2-hydroxybenzaldehyde (2) and 4-dimethylaminocinnamaldehyde (3), respectively. They showed good lipo...

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Autores principales: ASLAM,MUHAMMAD, ANIS,ITRAT, AFZA,NIGHAT, HUSSAIN,MUHAMMAD TAHIR, MEHMOOD,RASHAD, HUSSAIN,AJAZ, YOUSUF,SAMMER, IQBAL,LUBNA, IQBAL,SAMINA, KHAN,INAMULLAH
Lenguaje:English
Publicado: Sociedad Chilena de Química 2013
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300016
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spelling oai:scielo:S0717-970720130003000162014-09-09SYNTHESIS, X-RAY CRYSTALLOGRAPHY, MOLECULAR DOCKING AND BIOLOGICAL SCREENING OF 2-AMINOPHENOL BASED SCHIFF BASESASLAM,MUHAMMADANIS,ITRATAFZA,NIGHATHUSSAIN,MUHAMMAD TAHIRMEHMOOD,RASHADHUSSAIN,AJAZYOUSUF,SAMMERIQBAL,LUBNAIQBAL,SAMINAKHAN,INAMULLAH Schiff bases Synthesis X-ray diffraction Molecular docking Biological activities Schiff bases, 2-{[(2-hydroxyphenyl)methylidene]amino}phenol (4) and 2-{[3-4-(dimethylamino)phenyl-2-propenylidene]amino}phenol (5), have been synthesized by the condensation of 2-aminophenol (1) with 2-hydroxybenzaldehyde (2) and 4-dimethylaminocinnamaldehyde (3), respectively. They showed good lipoxygenase inhibition and antioxidant activities, as compound 4 showed potent antioxidant activity. The products also showed good activities against Gram-positive: S. intermedius, B. subtilis and S. aureus, and Gram-negative: E. coli and S. typhi bacteria, as compounds 5 and 4 are excellent active against B. subtilis and S. typhi, respectively. These good to potent activities may be due to the presence of free hydroxyl and amino groups. They showed non-significant urease inhibition activity.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.3 20132013-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300016en10.4067/S0717-97072013000300016
institution Scielo Chile
collection Scielo Chile
language English
topic Schiff bases
Synthesis
X-ray diffraction
Molecular docking
Biological activities
spellingShingle Schiff bases
Synthesis
X-ray diffraction
Molecular docking
Biological activities
ASLAM,MUHAMMAD
ANIS,ITRAT
AFZA,NIGHAT
HUSSAIN,MUHAMMAD TAHIR
MEHMOOD,RASHAD
HUSSAIN,AJAZ
YOUSUF,SAMMER
IQBAL,LUBNA
IQBAL,SAMINA
KHAN,INAMULLAH
SYNTHESIS, X-RAY CRYSTALLOGRAPHY, MOLECULAR DOCKING AND BIOLOGICAL SCREENING OF 2-AMINOPHENOL BASED SCHIFF BASES
description Schiff bases, 2-{[(2-hydroxyphenyl)methylidene]amino}phenol (4) and 2-{[3-4-(dimethylamino)phenyl-2-propenylidene]amino}phenol (5), have been synthesized by the condensation of 2-aminophenol (1) with 2-hydroxybenzaldehyde (2) and 4-dimethylaminocinnamaldehyde (3), respectively. They showed good lipoxygenase inhibition and antioxidant activities, as compound 4 showed potent antioxidant activity. The products also showed good activities against Gram-positive: S. intermedius, B. subtilis and S. aureus, and Gram-negative: E. coli and S. typhi bacteria, as compounds 5 and 4 are excellent active against B. subtilis and S. typhi, respectively. These good to potent activities may be due to the presence of free hydroxyl and amino groups. They showed non-significant urease inhibition activity.
author ASLAM,MUHAMMAD
ANIS,ITRAT
AFZA,NIGHAT
HUSSAIN,MUHAMMAD TAHIR
MEHMOOD,RASHAD
HUSSAIN,AJAZ
YOUSUF,SAMMER
IQBAL,LUBNA
IQBAL,SAMINA
KHAN,INAMULLAH
author_facet ASLAM,MUHAMMAD
ANIS,ITRAT
AFZA,NIGHAT
HUSSAIN,MUHAMMAD TAHIR
MEHMOOD,RASHAD
HUSSAIN,AJAZ
YOUSUF,SAMMER
IQBAL,LUBNA
IQBAL,SAMINA
KHAN,INAMULLAH
author_sort ASLAM,MUHAMMAD
title SYNTHESIS, X-RAY CRYSTALLOGRAPHY, MOLECULAR DOCKING AND BIOLOGICAL SCREENING OF 2-AMINOPHENOL BASED SCHIFF BASES
title_short SYNTHESIS, X-RAY CRYSTALLOGRAPHY, MOLECULAR DOCKING AND BIOLOGICAL SCREENING OF 2-AMINOPHENOL BASED SCHIFF BASES
title_full SYNTHESIS, X-RAY CRYSTALLOGRAPHY, MOLECULAR DOCKING AND BIOLOGICAL SCREENING OF 2-AMINOPHENOL BASED SCHIFF BASES
title_fullStr SYNTHESIS, X-RAY CRYSTALLOGRAPHY, MOLECULAR DOCKING AND BIOLOGICAL SCREENING OF 2-AMINOPHENOL BASED SCHIFF BASES
title_full_unstemmed SYNTHESIS, X-RAY CRYSTALLOGRAPHY, MOLECULAR DOCKING AND BIOLOGICAL SCREENING OF 2-AMINOPHENOL BASED SCHIFF BASES
title_sort synthesis, x-ray crystallography, molecular docking and biological screening of 2-aminophenol based schiff bases
publisher Sociedad Chilena de Química
publishDate 2013
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300016
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