SOLVENT-FREE C-ALKYLATION OF BARBITURIC ACID IN THE NANOCRYSTALLINE MORDENITE MEDIA
A simple, efficient and clean procedure has been developed for the C-alkylation of barbituric acid. The Michael addition of barbituric acid to α,β-unsaturated esters by employing K2CO3 in the nano-mordenite media (K2CO3/nano-MOR), as catalyst, gave C-alkylated barbituric acid in go...
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| Autores principales: | , , , , |
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| Lenguaje: | English |
| Publicado: |
Sociedad Chilena de Química
2013
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| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300021 |
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| Sumario: | A simple, efficient and clean procedure has been developed for the C-alkylation of barbituric acid. The Michael addition of barbituric acid to α,β-unsaturated esters by employing K2CO3 in the nano-mordenite media (K2CO3/nano-MOR), as catalyst, gave C-alkylated barbituric acid in good to excellent yield. Nano-MOR showed good reusability. K2CO3/nano-MOR catalyst has been found to be an excellent catalyst for the reaction under solvent-free conditions at 80-90 °C. |
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