KINETIC SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF MORPHINE, NALBUPHINE AND NALTREXONE DRUGS IN BULK AND PHARMACEUTICAL FORMULATIONS

A novel study describes the development and validation of a selective and simple kinetic spectrophotometric method for the determination of some analgesic drugs namely, morphine (MOF), nalbuphine (NAB) and naltrexone (NAT) in bulk and in pharmaceutical formulations. This method was based on the reac...

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Autores principales:	EL-DIDAMONY,AKRAM M, SAAD,MONIR Z, SALEEM,NORA O
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2013
Materias:	Kinetic spectrophotometric potassium permanganate NaOH morphine nalbuphine naltrexone dosage forms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300025
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spelling	oai:scielo:S0717-970720130003000252014-09-09KINETIC SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF MORPHINE, NALBUPHINE AND NALTREXONE DRUGS IN BULK AND PHARMACEUTICAL FORMULATIONSEL-DIDAMONY,AKRAM MSAAD,MONIR ZSALEEM,NORA O Kinetic spectrophotometric potassium permanganate NaOH morphine nalbuphine naltrexone dosage forms A novel study describes the development and validation of a selective and simple kinetic spectrophotometric method for the determination of some analgesic drugs namely, morphine (MOF), nalbuphine (NAB) and naltrexone (NAT) in bulk and in pharmaceutical formulations. This method was based on the reaction of the drugs under studying with alkaline KMnO4 to form a water-soluble bluish green colored product with a maximum absorbance at 605 nm. Although, the determination of MOF, NAB and NAT drugs by rate constant, fixed-concentration and fixed time methods were feasible with the calibration equations obtained, the fixed time method has been found to be more applicable. The fixed-time method is adopted for constructing the calibration curves, which were found to be linear over the concentration ranges of 4 - 18 μg mL-1 MOF, 2 - 20 μg mL-1 NAB and 2 - 16 μg mL-1 NAT. Different experimental parameters which can affect the development and stability of the color were carefully studied and optimized. The fixed time method of 20 min was further applied to pharmaceutical formulations of each drug and the percentage recoveries were 99.85±0.049 to 102.27±0.024. Statistical comparisons of the results with the reference methods show the excellent agreement and indicate no significant difference in accuracy and precision.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.3 20132013-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300025en10.4067/S0717-97072013000300025
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Kinetic spectrophotometric potassium permanganate NaOH morphine nalbuphine naltrexone dosage forms
spellingShingle	Kinetic spectrophotometric potassium permanganate NaOH morphine nalbuphine naltrexone dosage forms EL-DIDAMONY,AKRAM M SAAD,MONIR Z SALEEM,NORA O KINETIC SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF MORPHINE, NALBUPHINE AND NALTREXONE DRUGS IN BULK AND PHARMACEUTICAL FORMULATIONS
description	A novel study describes the development and validation of a selective and simple kinetic spectrophotometric method for the determination of some analgesic drugs namely, morphine (MOF), nalbuphine (NAB) and naltrexone (NAT) in bulk and in pharmaceutical formulations. This method was based on the reaction of the drugs under studying with alkaline KMnO4 to form a water-soluble bluish green colored product with a maximum absorbance at 605 nm. Although, the determination of MOF, NAB and NAT drugs by rate constant, fixed-concentration and fixed time methods were feasible with the calibration equations obtained, the fixed time method has been found to be more applicable. The fixed-time method is adopted for constructing the calibration curves, which were found to be linear over the concentration ranges of 4 - 18 μg mL-1 MOF, 2 - 20 μg mL-1 NAB and 2 - 16 μg mL-1 NAT. Different experimental parameters which can affect the development and stability of the color were carefully studied and optimized. The fixed time method of 20 min was further applied to pharmaceutical formulations of each drug and the percentage recoveries were 99.85±0.049 to 102.27±0.024. Statistical comparisons of the results with the reference methods show the excellent agreement and indicate no significant difference in accuracy and precision.
author	EL-DIDAMONY,AKRAM M SAAD,MONIR Z SALEEM,NORA O
author_facet	EL-DIDAMONY,AKRAM M SAAD,MONIR Z SALEEM,NORA O
author_sort	EL-DIDAMONY,AKRAM M
title	KINETIC SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF MORPHINE, NALBUPHINE AND NALTREXONE DRUGS IN BULK AND PHARMACEUTICAL FORMULATIONS
title_short	KINETIC SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF MORPHINE, NALBUPHINE AND NALTREXONE DRUGS IN BULK AND PHARMACEUTICAL FORMULATIONS
title_full	KINETIC SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF MORPHINE, NALBUPHINE AND NALTREXONE DRUGS IN BULK AND PHARMACEUTICAL FORMULATIONS
title_fullStr	KINETIC SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF MORPHINE, NALBUPHINE AND NALTREXONE DRUGS IN BULK AND PHARMACEUTICAL FORMULATIONS
title_full_unstemmed	KINETIC SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF MORPHINE, NALBUPHINE AND NALTREXONE DRUGS IN BULK AND PHARMACEUTICAL FORMULATIONS
title_sort	kinetic spectrophotometry method for the determination of morphine, nalbuphine and naltrexone drugs in bulk and pharmaceutical formulations
publisher	Sociedad Chilena de Química
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300025
work_keys_str_mv	AT eldidamonyakramm kineticspectrophotometrymethodforthedeterminationofmorphinenalbuphineandnaltrexonedrugsinbulkandpharmaceuticalformulations AT saadmonirz kineticspectrophotometrymethodforthedeterminationofmorphinenalbuphineandnaltrexonedrugsinbulkandpharmaceuticalformulations AT saleemnorao kineticspectrophotometrymethodforthedeterminationofmorphinenalbuphineandnaltrexonedrugsinbulkandpharmaceuticalformulations
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KINETIC SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF MORPHINE, NALBUPHINE AND NALTREXONE DRUGS IN BULK AND PHARMACEUTICAL FORMULATIONS

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