SINGLE-STEP SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL STEROIDAL 1', 2', 3'- THIADIAZOLES

A convenient one-step synthesis of steroidal thiadiazoles 7-9 from steroidal 6-ketone semicarbazones 1-3 with thionyl chloride has been reported. The steroidal 6-ketone thiosemicarbazones 4-6 under similar reaction conditions also provided the same products 7-9. The structures of these newly synthes...

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Autores principales:	SIDDIQUI,NAZISH, SHAMSUZZAMAN
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2013
Materias:	Steroidal thiadiazoles Semicarbazones thiosemicarbazones Thionyl chloride Antimicrobial activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300031
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spelling	oai:scielo:S0717-970720130003000312014-09-09SINGLE-STEP SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL STEROIDAL 1', 2', 3'- THIADIAZOLESSIDDIQUI,NAZISHSHAMSUZZAMAN, Steroidal thiadiazoles Semicarbazones thiosemicarbazones Thionyl chloride Antimicrobial activity A convenient one-step synthesis of steroidal thiadiazoles 7-9 from steroidal 6-ketone semicarbazones 1-3 with thionyl chloride has been reported. The steroidal 6-ketone thiosemicarbazones 4-6 under similar reaction conditions also provided the same products 7-9. The structures of these newly synthesized compounds have been established on the basis of their IR, ¹H NMR and 13C NMR, elemental and analytical data. The synthesized compounds were screened for in vitro antimicrobial activity against different bacterial (gram positive and gram negative) and fungal strains. All the synthesized compounds showed significant activity against various micro-organisms.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.3 20132013-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300031en10.4067/S0717-97072013000300031
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Steroidal thiadiazoles Semicarbazones thiosemicarbazones Thionyl chloride Antimicrobial activity
spellingShingle	Steroidal thiadiazoles Semicarbazones thiosemicarbazones Thionyl chloride Antimicrobial activity SIDDIQUI,NAZISH SHAMSUZZAMAN, SINGLE-STEP SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL STEROIDAL 1', 2', 3'- THIADIAZOLES
description	A convenient one-step synthesis of steroidal thiadiazoles 7-9 from steroidal 6-ketone semicarbazones 1-3 with thionyl chloride has been reported. The steroidal 6-ketone thiosemicarbazones 4-6 under similar reaction conditions also provided the same products 7-9. The structures of these newly synthesized compounds have been established on the basis of their IR, ¹H NMR and 13C NMR, elemental and analytical data. The synthesized compounds were screened for in vitro antimicrobial activity against different bacterial (gram positive and gram negative) and fungal strains. All the synthesized compounds showed significant activity against various micro-organisms.
author	SIDDIQUI,NAZISH SHAMSUZZAMAN,
author_facet	SIDDIQUI,NAZISH SHAMSUZZAMAN,
author_sort	SIDDIQUI,NAZISH
title	SINGLE-STEP SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL STEROIDAL 1', 2', 3'- THIADIAZOLES
title_short	SINGLE-STEP SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL STEROIDAL 1', 2', 3'- THIADIAZOLES
title_full	SINGLE-STEP SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL STEROIDAL 1', 2', 3'- THIADIAZOLES
title_fullStr	SINGLE-STEP SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL STEROIDAL 1', 2', 3'- THIADIAZOLES
title_full_unstemmed	SINGLE-STEP SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL STEROIDAL 1', 2', 3'- THIADIAZOLES
title_sort	single-step synthesis, characterization and antimicrobial studies of novel steroidal 1', 2', 3'- thiadiazoles
publisher	Sociedad Chilena de Química
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300031
work_keys_str_mv	AT siddiquinazish singlestepsynthesischaracterizationandantimicrobialstudiesofnovelsteroidal123thiadiazoles AT shamsuzzaman singlestepsynthesischaracterizationandantimicrobialstudiesofnovelsteroidal123thiadiazoles
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SINGLE-STEP SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL STEROIDAL 1', 2', 3'- THIADIAZOLES

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