COUMARINS OF HAPLOPAPPUS MULTIFOLIUS AND DERIVATIVE AS INHIBITORS OF LOX: EVALUATION IN-VITRO AND DOCKING STUDIES

Several natural compounds containing a coumarin moiety have been reported. They have multiple biological activities, e.g., as scavengers of reactive oxygen species (ROS) and to reduce the inflammatory processes by inhibition of enzymes like COX or LOX. A study was made of the inhibitory capacity of...

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Autores principales:	TORRES,RENE, MASCAYANO,CAROLINA, NÚÑEZ,CAROLINA, MODAK,BRENDA, FAINI,FRANCESCA
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2013
Materias:	Soybean lipoxygenase human lipoxygenase coumarin inhibitors of LOX percent inhibition values docking
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000400027
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spelling	oai:scielo:S0717-970720130004000272014-09-02COUMARINS OF HAPLOPAPPUS MULTIFOLIUS AND DERIVATIVE AS INHIBITORS OF LOX: EVALUATION IN-VITRO AND DOCKING STUDIESTORRES,RENEMASCAYANO,CAROLINANÚÑEZ,CAROLINAMODAK,BRENDAFAINI,FRANCESCA Soybean lipoxygenase human lipoxygenase coumarin inhibitors of LOX percent inhibition values docking Several natural compounds containing a coumarin moiety have been reported. They have multiple biological activities, e.g., as scavengers of reactive oxygen species (ROS) and to reduce the inflammatory processes by inhibition of enzymes like COX or LOX. A study was made of the inhibitory capacity of seven natural coumarins and one derivative of esculetin, against soybean 15-lipoxygenase (15-sLOX). The studied coumarins showed interesting degrees of inhibition compared to quercetin, a known LOX inhibitor. Docking studies of some compounds into the binding site of 15-sLOX and 5-hLOX were also made.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.4 20132013-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000400027en10.4067/S0717-97072013000400027
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Soybean lipoxygenase human lipoxygenase coumarin inhibitors of LOX percent inhibition values docking
spellingShingle	Soybean lipoxygenase human lipoxygenase coumarin inhibitors of LOX percent inhibition values docking TORRES,RENE MASCAYANO,CAROLINA NÚÑEZ,CAROLINA MODAK,BRENDA FAINI,FRANCESCA COUMARINS OF HAPLOPAPPUS MULTIFOLIUS AND DERIVATIVE AS INHIBITORS OF LOX: EVALUATION IN-VITRO AND DOCKING STUDIES
description	Several natural compounds containing a coumarin moiety have been reported. They have multiple biological activities, e.g., as scavengers of reactive oxygen species (ROS) and to reduce the inflammatory processes by inhibition of enzymes like COX or LOX. A study was made of the inhibitory capacity of seven natural coumarins and one derivative of esculetin, against soybean 15-lipoxygenase (15-sLOX). The studied coumarins showed interesting degrees of inhibition compared to quercetin, a known LOX inhibitor. Docking studies of some compounds into the binding site of 15-sLOX and 5-hLOX were also made.
author	TORRES,RENE MASCAYANO,CAROLINA NÚÑEZ,CAROLINA MODAK,BRENDA FAINI,FRANCESCA
author_facet	TORRES,RENE MASCAYANO,CAROLINA NÚÑEZ,CAROLINA MODAK,BRENDA FAINI,FRANCESCA
author_sort	TORRES,RENE
title	COUMARINS OF HAPLOPAPPUS MULTIFOLIUS AND DERIVATIVE AS INHIBITORS OF LOX: EVALUATION IN-VITRO AND DOCKING STUDIES
title_short	COUMARINS OF HAPLOPAPPUS MULTIFOLIUS AND DERIVATIVE AS INHIBITORS OF LOX: EVALUATION IN-VITRO AND DOCKING STUDIES
title_full	COUMARINS OF HAPLOPAPPUS MULTIFOLIUS AND DERIVATIVE AS INHIBITORS OF LOX: EVALUATION IN-VITRO AND DOCKING STUDIES
title_fullStr	COUMARINS OF HAPLOPAPPUS MULTIFOLIUS AND DERIVATIVE AS INHIBITORS OF LOX: EVALUATION IN-VITRO AND DOCKING STUDIES
title_full_unstemmed	COUMARINS OF HAPLOPAPPUS MULTIFOLIUS AND DERIVATIVE AS INHIBITORS OF LOX: EVALUATION IN-VITRO AND DOCKING STUDIES
title_sort	coumarins of haplopappus multifolius and derivative as inhibitors of lox: evaluation in-vitro and docking studies
publisher	Sociedad Chilena de Química
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000400027
work_keys_str_mv	AT torresrene coumarinsofhaplopappusmultifoliusandderivativeasinhibitorsofloxevaluationinvitroanddockingstudies AT mascayanocarolina coumarinsofhaplopappusmultifoliusandderivativeasinhibitorsofloxevaluationinvitroanddockingstudies AT nunezcarolina coumarinsofhaplopappusmultifoliusandderivativeasinhibitorsofloxevaluationinvitroanddockingstudies AT modakbrenda coumarinsofhaplopappusmultifoliusandderivativeasinhibitorsofloxevaluationinvitroanddockingstudies AT fainifrancesca coumarinsofhaplopappusmultifoliusandderivativeasinhibitorsofloxevaluationinvitroanddockingstudies
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COUMARINS OF HAPLOPAPPUS MULTIFOLIUS AND DERIVATIVE AS INHIBITORS OF LOX: EVALUATION IN-VITRO AND DOCKING STUDIES

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