SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ENZYME INHIBITION STUDIES ON 5-(2-NITROSTYRYL)-1,3,4-OXADIAZOLE-2-THIOL DERIVATIVES

In the present work, S-substituted derivatives of 5-(2-nitrostyryl)-1,3,4-oxadiazole-2-thiol (4) were synthesized by successive conversions of 3-(2-nitrophenyl) acrylic acid (1) into its respective ester, hydrazide and 1,3,4-oxadiazole. Finally the target compounds were obtained by reaction of 5-(2-...

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Autores principales:	ABBASI,MUHAMMAD ATHAR, AKHTAR,ADNAN, AZIZ-UR-REHMAN, NAFEESA,KHADIJA, SIDDIQUI,SABAHAT ZAHRA, KHAN,KHALID MOHAMMED, ASHRAF,MUHAMMAD, EJAZ,SYEDA ABIDA
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2013
Materias:	3-(2-nitrophenyl)acrylic acid 5-(2-nitrostyryl)-1,3,4-oxadiazole-2-thiol ¹H-NMR EI-MS enzymatic activities
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000400061
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spelling	oai:scielo:S0717-970720130004000612014-09-02SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ENZYME INHIBITION STUDIES ON 5-(2-NITROSTYRYL)-1,3,4-OXADIAZOLE-2-THIOL DERIVATIVESABBASI,MUHAMMAD ATHARAKHTAR,ADNANAZIZ-UR-REHMAN,NAFEESA,KHADIJASIDDIQUI,SABAHAT ZAHRAKHAN,KHALID MOHAMMEDASHRAF,MUHAMMADEJAZ,SYEDA ABIDA 3-(2-nitrophenyl)acrylic acid 5-(2-nitrostyryl)-1,3,4-oxadiazole-2-thiol ¹H-NMR EI-MS enzymatic activities In the present work, S-substituted derivatives of 5-(2-nitrostyryl)-1,3,4-oxadiazole-2-thiol (4) were synthesized by successive conversions of 3-(2-nitrophenyl) acrylic acid (1) into its respective ester, hydrazide and 1,3,4-oxadiazole. Finally the target compounds were obtained by reaction of 5-(2-nitrostyryl)-1,3,4-oxadiazole-2-thiol (4) with a series of various electrophiles, (5a-I), in NN-dimethyl formamide (DMF) in the presence of sodium hydride (NaH). The structural characterization of these newly synthesized compounds was done by IR, ¹H-NMR, HR-MS and EI-MS spectral data. All these compounds were evaluated for their enzyme inhibitory potentials and found to exhibit broad range spectrum against acetylcholinesterase, butyrylcholinestrase and lipoxygenase enzymes.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.4 20132013-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000400061en10.4067/S0717-97072013000400061
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	3-(2-nitrophenyl)acrylic acid 5-(2-nitrostyryl)-1,3,4-oxadiazole-2-thiol ¹H-NMR EI-MS enzymatic activities
spellingShingle	3-(2-nitrophenyl)acrylic acid 5-(2-nitrostyryl)-1,3,4-oxadiazole-2-thiol ¹H-NMR EI-MS enzymatic activities ABBASI,MUHAMMAD ATHAR AKHTAR,ADNAN AZIZ-UR-REHMAN, NAFEESA,KHADIJA SIDDIQUI,SABAHAT ZAHRA KHAN,KHALID MOHAMMED ASHRAF,MUHAMMAD EJAZ,SYEDA ABIDA SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ENZYME INHIBITION STUDIES ON 5-(2-NITROSTYRYL)-1,3,4-OXADIAZOLE-2-THIOL DERIVATIVES
description	In the present work, S-substituted derivatives of 5-(2-nitrostyryl)-1,3,4-oxadiazole-2-thiol (4) were synthesized by successive conversions of 3-(2-nitrophenyl) acrylic acid (1) into its respective ester, hydrazide and 1,3,4-oxadiazole. Finally the target compounds were obtained by reaction of 5-(2-nitrostyryl)-1,3,4-oxadiazole-2-thiol (4) with a series of various electrophiles, (5a-I), in NN-dimethyl formamide (DMF) in the presence of sodium hydride (NaH). The structural characterization of these newly synthesized compounds was done by IR, ¹H-NMR, HR-MS and EI-MS spectral data. All these compounds were evaluated for their enzyme inhibitory potentials and found to exhibit broad range spectrum against acetylcholinesterase, butyrylcholinestrase and lipoxygenase enzymes.
author	ABBASI,MUHAMMAD ATHAR AKHTAR,ADNAN AZIZ-UR-REHMAN, NAFEESA,KHADIJA SIDDIQUI,SABAHAT ZAHRA KHAN,KHALID MOHAMMED ASHRAF,MUHAMMAD EJAZ,SYEDA ABIDA
author_facet	ABBASI,MUHAMMAD ATHAR AKHTAR,ADNAN AZIZ-UR-REHMAN, NAFEESA,KHADIJA SIDDIQUI,SABAHAT ZAHRA KHAN,KHALID MOHAMMED ASHRAF,MUHAMMAD EJAZ,SYEDA ABIDA
author_sort	ABBASI,MUHAMMAD ATHAR
title	SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ENZYME INHIBITION STUDIES ON 5-(2-NITROSTYRYL)-1,3,4-OXADIAZOLE-2-THIOL DERIVATIVES
title_short	SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ENZYME INHIBITION STUDIES ON 5-(2-NITROSTYRYL)-1,3,4-OXADIAZOLE-2-THIOL DERIVATIVES
title_full	SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ENZYME INHIBITION STUDIES ON 5-(2-NITROSTYRYL)-1,3,4-OXADIAZOLE-2-THIOL DERIVATIVES
title_fullStr	SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ENZYME INHIBITION STUDIES ON 5-(2-NITROSTYRYL)-1,3,4-OXADIAZOLE-2-THIOL DERIVATIVES
title_full_unstemmed	SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ENZYME INHIBITION STUDIES ON 5-(2-NITROSTYRYL)-1,3,4-OXADIAZOLE-2-THIOL DERIVATIVES
title_sort	synthesis, structural characterization and enzyme inhibition studies on 5-(2-nitrostyryl)-1,3,4-oxadiazole-2-thiol derivatives
publisher	Sociedad Chilena de Química
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000400061
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_version_	1718445507106308096

SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ENZYME INHIBITION STUDIES ON 5-(2-NITROSTYRYL)-1,3,4-OXADIAZOLE-2-THIOL DERIVATIVES

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