SPECTROPHOTOMETRIC DETERMINATION OF AMITRIPTYLINE HCl IN PURE AND PHARMACEUTICAL FORMS

Five spectrophotometric methods for determination of Amitriptyline HCl have been developed, validated and applied for the assay of the drug in pharmaceuticals. Methods A, B and C are based on ion pair complexation of drug, in acidic buffers, with triphenylmethane dyes viz., Bromothymol blue (BTB), B...

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Autores principales:	SUSMITHA,K, THIRUMALACHARY,M, CHARAN SINGH,T, VENKATESHWARLU,G
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2014
Materias:	Spectrophotometry Amitriptyline HCl Bromothymol blue Bromophenol blue Bromocresol purple Iodine Alkaline KMnO4
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000100005
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spelling	oai:scielo:S0717-970720140001000052015-11-12SPECTROPHOTOMETRIC DETERMINATION OF AMITRIPTYLINE HCl IN PURE AND PHARMACEUTICAL FORMSSUSMITHA,KTHIRUMALACHARY,MCHARAN SINGH,TVENKATESHWARLU,G Spectrophotometry Amitriptyline HCl Bromothymol blue Bromophenol blue Bromocresol purple Iodine Alkaline KMnO4 Five spectrophotometric methods for determination of Amitriptyline HCl have been developed, validated and applied for the assay of the drug in pharmaceuticals. Methods A, B and C are based on ion pair complexation of drug, in acidic buffers, with triphenylmethane dyes viz., Bromothymol blue (BTB), Bromophenol blue (BPB) and Bromocresol purple (BCP). The complexes are extracted into chloroform and absorbance is measured around at 415 nm as function of concentration of the drug. The stoichiometry of the complex is found 1:1 in each case. Method D depends upon charge transfer complexation of neutralized drug with iodine which produces iodide ion whose absorbance at 366 nm is measured as function of concentration of the drug. This complex, too, has 1:1 composition as determined by Job's method. Method E is developed on the basis of oxidation of the drug with alkaline KMnO4 which generates green colored manganate ion with λmax 610 nm. As the intensity of green color increased with increasing time kinetics of the reaction is followed and calibration curves are constructed by using initial rate and fixed time methods. Excellent recovery studies with high accuracy and precision indicate that the methods can be successfully used in industries for the assay of drug in pure form and pharmaceuticals.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.59 n.1 20142014-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000100005en10.4067/S0717-97072014000100005
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Spectrophotometry Amitriptyline HCl Bromothymol blue Bromophenol blue Bromocresol purple Iodine Alkaline KMnO4
spellingShingle	Spectrophotometry Amitriptyline HCl Bromothymol blue Bromophenol blue Bromocresol purple Iodine Alkaline KMnO4 SUSMITHA,K THIRUMALACHARY,M CHARAN SINGH,T VENKATESHWARLU,G SPECTROPHOTOMETRIC DETERMINATION OF AMITRIPTYLINE HCl IN PURE AND PHARMACEUTICAL FORMS
description	Five spectrophotometric methods for determination of Amitriptyline HCl have been developed, validated and applied for the assay of the drug in pharmaceuticals. Methods A, B and C are based on ion pair complexation of drug, in acidic buffers, with triphenylmethane dyes viz., Bromothymol blue (BTB), Bromophenol blue (BPB) and Bromocresol purple (BCP). The complexes are extracted into chloroform and absorbance is measured around at 415 nm as function of concentration of the drug. The stoichiometry of the complex is found 1:1 in each case. Method D depends upon charge transfer complexation of neutralized drug with iodine which produces iodide ion whose absorbance at 366 nm is measured as function of concentration of the drug. This complex, too, has 1:1 composition as determined by Job's method. Method E is developed on the basis of oxidation of the drug with alkaline KMnO4 which generates green colored manganate ion with λmax 610 nm. As the intensity of green color increased with increasing time kinetics of the reaction is followed and calibration curves are constructed by using initial rate and fixed time methods. Excellent recovery studies with high accuracy and precision indicate that the methods can be successfully used in industries for the assay of drug in pure form and pharmaceuticals.
author	SUSMITHA,K THIRUMALACHARY,M CHARAN SINGH,T VENKATESHWARLU,G
author_facet	SUSMITHA,K THIRUMALACHARY,M CHARAN SINGH,T VENKATESHWARLU,G
author_sort	SUSMITHA,K
title	SPECTROPHOTOMETRIC DETERMINATION OF AMITRIPTYLINE HCl IN PURE AND PHARMACEUTICAL FORMS
title_short	SPECTROPHOTOMETRIC DETERMINATION OF AMITRIPTYLINE HCl IN PURE AND PHARMACEUTICAL FORMS
title_full	SPECTROPHOTOMETRIC DETERMINATION OF AMITRIPTYLINE HCl IN PURE AND PHARMACEUTICAL FORMS
title_fullStr	SPECTROPHOTOMETRIC DETERMINATION OF AMITRIPTYLINE HCl IN PURE AND PHARMACEUTICAL FORMS
title_full_unstemmed	SPECTROPHOTOMETRIC DETERMINATION OF AMITRIPTYLINE HCl IN PURE AND PHARMACEUTICAL FORMS
title_sort	spectrophotometric determination of amitriptyline hcl in pure and pharmaceutical forms
publisher	Sociedad Chilena de Química
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000100005
work_keys_str_mv	AT susmithak spectrophotometricdeterminationofamitriptylinehclinpureandpharmaceuticalforms AT thirumalacharym spectrophotometricdeterminationofamitriptylinehclinpureandpharmaceuticalforms AT charansinght spectrophotometricdeterminationofamitriptylinehclinpureandpharmaceuticalforms AT venkateshwarlug spectrophotometricdeterminationofamitriptylinehclinpureandpharmaceuticalforms
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SPECTROPHOTOMETRIC DETERMINATION OF AMITRIPTYLINE HCl IN PURE AND PHARMACEUTICAL FORMS

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