A CONVENIENT SYNTHESIS AND CYTOTOXIC ACTIVITY OF 3-ARYL-5-PENTYL-1,2,4-OXADIAZOLES FROM CARBOXYLIC ACID ESTERS AND ARYLAMIDOXIMES UNDER SOLVENT-FREE CONDITIONS

The synthesis of 3-aryl-5-pentyl-1,2,4-oxadiazoles from carboxylic acid esters and arylamidoximes in the presence of potassium carbonate is described. The reaction was carried out in a microwave oven without any solvent in much shorter time and in good yields. The structures of the synthesized compo...

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Autores principales:	PIMENTEL BARROS,CARLOS JONNATAN, CARDOSO DE SOUZA,ZILYANE, RUFINO DE FREITAS,JUCLEITON JOSÉ, NORBERTO DA SILVA,PAULO BRUNO, GADELHA MILITÃO,GARDENIA CARMEN, GONÇALVES DA SILVA,TERESINHA, RUFINO FREITAS,JULIANO CARLO, RUFINO DE FREITAS FILHO,JOÃO
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2014
Materias:	1,2,4-Oxadiazoles Amidoximes Microwave oven Cytotoxic Activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000100024
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spelling	oai:scielo:S0717-970720140001000242015-11-12A CONVENIENT SYNTHESIS AND CYTOTOXIC ACTIVITY OF 3-ARYL-5-PENTYL-1,2,4-OXADIAZOLES FROM CARBOXYLIC ACID ESTERS AND ARYLAMIDOXIMES UNDER SOLVENT-FREE CONDITIONSPIMENTEL BARROS,CARLOS JONNATANCARDOSO DE SOUZA,ZILYANERUFINO DE FREITAS,JUCLEITON JOSÉNORBERTO DA SILVA,PAULO BRUNOGADELHA MILITÃO,GARDENIA CARMENGONÇALVES DA SILVA,TERESINHARUFINO FREITAS,JULIANO CARLORUFINO DE FREITAS FILHO,JOÃO 1,2,4-Oxadiazoles Amidoximes Microwave oven Cytotoxic Activity The synthesis of 3-aryl-5-pentyl-1,2,4-oxadiazoles from carboxylic acid esters and arylamidoximes in the presence of potassium carbonate is described. The reaction was carried out in a microwave oven without any solvent in much shorter time and in good yields. The structures of the synthesized compounds were elucidated using IR, ¹H and 13C NMR spectroscopy and elemental analysis and their antiproliferative activities was evaluated against three different human cell lines.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.59 n.1 20142014-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000100024en10.4067/S0717-97072014000100024
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	1,2,4-Oxadiazoles Amidoximes Microwave oven Cytotoxic Activity
spellingShingle	1,2,4-Oxadiazoles Amidoximes Microwave oven Cytotoxic Activity PIMENTEL BARROS,CARLOS JONNATAN CARDOSO DE SOUZA,ZILYANE RUFINO DE FREITAS,JUCLEITON JOSÉ NORBERTO DA SILVA,PAULO BRUNO GADELHA MILITÃO,GARDENIA CARMEN GONÇALVES DA SILVA,TERESINHA RUFINO FREITAS,JULIANO CARLO RUFINO DE FREITAS FILHO,JOÃO A CONVENIENT SYNTHESIS AND CYTOTOXIC ACTIVITY OF 3-ARYL-5-PENTYL-1,2,4-OXADIAZOLES FROM CARBOXYLIC ACID ESTERS AND ARYLAMIDOXIMES UNDER SOLVENT-FREE CONDITIONS
description	The synthesis of 3-aryl-5-pentyl-1,2,4-oxadiazoles from carboxylic acid esters and arylamidoximes in the presence of potassium carbonate is described. The reaction was carried out in a microwave oven without any solvent in much shorter time and in good yields. The structures of the synthesized compounds were elucidated using IR, ¹H and 13C NMR spectroscopy and elemental analysis and their antiproliferative activities was evaluated against three different human cell lines.
author	PIMENTEL BARROS,CARLOS JONNATAN CARDOSO DE SOUZA,ZILYANE RUFINO DE FREITAS,JUCLEITON JOSÉ NORBERTO DA SILVA,PAULO BRUNO GADELHA MILITÃO,GARDENIA CARMEN GONÇALVES DA SILVA,TERESINHA RUFINO FREITAS,JULIANO CARLO RUFINO DE FREITAS FILHO,JOÃO
author_facet	PIMENTEL BARROS,CARLOS JONNATAN CARDOSO DE SOUZA,ZILYANE RUFINO DE FREITAS,JUCLEITON JOSÉ NORBERTO DA SILVA,PAULO BRUNO GADELHA MILITÃO,GARDENIA CARMEN GONÇALVES DA SILVA,TERESINHA RUFINO FREITAS,JULIANO CARLO RUFINO DE FREITAS FILHO,JOÃO
author_sort	PIMENTEL BARROS,CARLOS JONNATAN
title	A CONVENIENT SYNTHESIS AND CYTOTOXIC ACTIVITY OF 3-ARYL-5-PENTYL-1,2,4-OXADIAZOLES FROM CARBOXYLIC ACID ESTERS AND ARYLAMIDOXIMES UNDER SOLVENT-FREE CONDITIONS
title_short	A CONVENIENT SYNTHESIS AND CYTOTOXIC ACTIVITY OF 3-ARYL-5-PENTYL-1,2,4-OXADIAZOLES FROM CARBOXYLIC ACID ESTERS AND ARYLAMIDOXIMES UNDER SOLVENT-FREE CONDITIONS
title_full	A CONVENIENT SYNTHESIS AND CYTOTOXIC ACTIVITY OF 3-ARYL-5-PENTYL-1,2,4-OXADIAZOLES FROM CARBOXYLIC ACID ESTERS AND ARYLAMIDOXIMES UNDER SOLVENT-FREE CONDITIONS
title_fullStr	A CONVENIENT SYNTHESIS AND CYTOTOXIC ACTIVITY OF 3-ARYL-5-PENTYL-1,2,4-OXADIAZOLES FROM CARBOXYLIC ACID ESTERS AND ARYLAMIDOXIMES UNDER SOLVENT-FREE CONDITIONS
title_full_unstemmed	A CONVENIENT SYNTHESIS AND CYTOTOXIC ACTIVITY OF 3-ARYL-5-PENTYL-1,2,4-OXADIAZOLES FROM CARBOXYLIC ACID ESTERS AND ARYLAMIDOXIMES UNDER SOLVENT-FREE CONDITIONS
title_sort	convenient synthesis and cytotoxic activity of 3-aryl-5-pentyl-1,2,4-oxadiazoles from carboxylic acid esters and arylamidoximes under solvent-free conditions
publisher	Sociedad Chilena de Química
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000100024
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A CONVENIENT SYNTHESIS AND CYTOTOXIC ACTIVITY OF 3-ARYL-5-PENTYL-1,2,4-OXADIAZOLES FROM CARBOXYLIC ACID ESTERS AND ARYLAMIDOXIMES UNDER SOLVENT-FREE CONDITIONS

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