AMMONIA AS A MODIFIER IN ION MOBILITY SPECTROMETRY: EFFECTS ON ION MOBILITIES AND POTENTIAL AS A SEPARATION TOOL

A commercial ammonia solution was introduced in the buffer gas of an ion mobility spectrometer and the mobilities of tetramethylammonium (TMA), tetraethylammonium (TEA), tetrapropylammonium (TPA), and tetrabutylammonium (TBA) ions, tribenzylamine (TBzA), tributylamine (TBtA), 2,4-dimethyl pyridine (...

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Autores principales:	FERNÁNDEZ-MAESTRE,ROBERTO, WU,CHING, HILL JR,HERBERT H
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2014
Materias:	Ion mobility spectrometry gas modifier ammonia clustering dopant
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000100032
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spelling	oai:scielo:S0717-970720140001000322015-11-12AMMONIA AS A MODIFIER IN ION MOBILITY SPECTROMETRY: EFFECTS ON ION MOBILITIES AND POTENTIAL AS A SEPARATION TOOLFERNÁNDEZ-MAESTRE,ROBERTOWU,CHINGHILL JR,HERBERT H Ion mobility spectrometry gas modifier ammonia clustering dopant A commercial ammonia solution was introduced in the buffer gas of an ion mobility spectrometer and the mobilities of tetramethylammonium (TMA), tetraethylammonium (TEA), tetrapropylammonium (TPA), and tetrabutylammonium (TBA) ions, tribenzylamine (TBzA), tributylamine (TBtA), 2,4-dimethyl pyridine (2,4-lutidine), 2,6-di-tert-butyl pyridine (DTBP), serine, atenolol, and valinol decreased depending on their structures. Electrospray ionization-ion mobility spectrometry-quadrupole mass spectrometry was used in these experiments. Analyte ion mobilities decreased to different extents with the amount of ammonia introduced in the mobility spectrometer. When the amount of ammonia increased from 0.0 to 22 mmol m-3 (with a concomitant concentration of water of 106 mmol m-3), percentage reductions in mobilities were: -4.8% (serine), -1.9% (reactant ions), -1.1% (TBtA), -0.9% (TBzA), -0.5% (TEA), -0.4% (valinol and TBA), -0.3% (TEA, TMA, and 2,4-lutidine), and 0% (atenolol and DTBP). These selective variations in mobilities were due to formation of large analyte ion-ammonia-water clusters. The small change in mobility of tetraalkylammonium ions, TBzA, TBtA, atenolol, and DTBP with the introduction of ammonia into the buffer gas was explained by steric hindrance of bulky substituents which shielded the positive charge of the ion from the attachment of ammonia and water molecules, and delocalized the positive charge. Ammonia in the buffer gas produced ion clusters with one or two ammonia molecules in compounds with little steric hindrance such as serine. At concentrations of ammonia of 4.4 mmol m-3 or higher (at 150°C), ligand-saturation with ammonia and water molecules occurred on the positive charge of some ions; when the positive charge saturated, no significant reductions in ion mobility occurred when increasing the concentration of ammonia in the buffer gas.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.59 n.1 20142014-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000100032en10.4067/S0717-97072014000100032
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Ion mobility spectrometry gas modifier ammonia clustering dopant
spellingShingle	Ion mobility spectrometry gas modifier ammonia clustering dopant FERNÁNDEZ-MAESTRE,ROBERTO WU,CHING HILL JR,HERBERT H AMMONIA AS A MODIFIER IN ION MOBILITY SPECTROMETRY: EFFECTS ON ION MOBILITIES AND POTENTIAL AS A SEPARATION TOOL
description	A commercial ammonia solution was introduced in the buffer gas of an ion mobility spectrometer and the mobilities of tetramethylammonium (TMA), tetraethylammonium (TEA), tetrapropylammonium (TPA), and tetrabutylammonium (TBA) ions, tribenzylamine (TBzA), tributylamine (TBtA), 2,4-dimethyl pyridine (2,4-lutidine), 2,6-di-tert-butyl pyridine (DTBP), serine, atenolol, and valinol decreased depending on their structures. Electrospray ionization-ion mobility spectrometry-quadrupole mass spectrometry was used in these experiments. Analyte ion mobilities decreased to different extents with the amount of ammonia introduced in the mobility spectrometer. When the amount of ammonia increased from 0.0 to 22 mmol m-3 (with a concomitant concentration of water of 106 mmol m-3), percentage reductions in mobilities were: -4.8% (serine), -1.9% (reactant ions), -1.1% (TBtA), -0.9% (TBzA), -0.5% (TEA), -0.4% (valinol and TBA), -0.3% (TEA, TMA, and 2,4-lutidine), and 0% (atenolol and DTBP). These selective variations in mobilities were due to formation of large analyte ion-ammonia-water clusters. The small change in mobility of tetraalkylammonium ions, TBzA, TBtA, atenolol, and DTBP with the introduction of ammonia into the buffer gas was explained by steric hindrance of bulky substituents which shielded the positive charge of the ion from the attachment of ammonia and water molecules, and delocalized the positive charge. Ammonia in the buffer gas produced ion clusters with one or two ammonia molecules in compounds with little steric hindrance such as serine. At concentrations of ammonia of 4.4 mmol m-3 or higher (at 150°C), ligand-saturation with ammonia and water molecules occurred on the positive charge of some ions; when the positive charge saturated, no significant reductions in ion mobility occurred when increasing the concentration of ammonia in the buffer gas.
author	FERNÁNDEZ-MAESTRE,ROBERTO WU,CHING HILL JR,HERBERT H
author_facet	FERNÁNDEZ-MAESTRE,ROBERTO WU,CHING HILL JR,HERBERT H
author_sort	FERNÁNDEZ-MAESTRE,ROBERTO
title	AMMONIA AS A MODIFIER IN ION MOBILITY SPECTROMETRY: EFFECTS ON ION MOBILITIES AND POTENTIAL AS A SEPARATION TOOL
title_short	AMMONIA AS A MODIFIER IN ION MOBILITY SPECTROMETRY: EFFECTS ON ION MOBILITIES AND POTENTIAL AS A SEPARATION TOOL
title_full	AMMONIA AS A MODIFIER IN ION MOBILITY SPECTROMETRY: EFFECTS ON ION MOBILITIES AND POTENTIAL AS A SEPARATION TOOL
title_fullStr	AMMONIA AS A MODIFIER IN ION MOBILITY SPECTROMETRY: EFFECTS ON ION MOBILITIES AND POTENTIAL AS A SEPARATION TOOL
title_full_unstemmed	AMMONIA AS A MODIFIER IN ION MOBILITY SPECTROMETRY: EFFECTS ON ION MOBILITIES AND POTENTIAL AS A SEPARATION TOOL
title_sort	ammonia as a modifier in ion mobility spectrometry: effects on ion mobilities and potential as a separation tool
publisher	Sociedad Chilena de Química
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000100032
work_keys_str_mv	AT fernandezmaestreroberto ammoniaasamodifierinionmobilityspectrometryeffectsonionmobilitiesandpotentialasaseparationtool AT wuching ammoniaasamodifierinionmobilityspectrometryeffectsonionmobilitiesandpotentialasaseparationtool AT hilljrherberth ammoniaasamodifierinionmobilityspectrometryeffectsonionmobilitiesandpotentialasaseparationtool
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AMMONIA AS A MODIFIER IN ION MOBILITY SPECTROMETRY: EFFECTS ON ION MOBILITIES AND POTENTIAL AS A SEPARATION TOOL

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