KINETIC SPECTROPHOTOMETRIC METHOD FOR THE QUANTITATIVE ANALYSIS OF STREPTOMYCIN SULFATE

Kinetic method has been developed for the quantitative analysis of streptomycin. The method is based on the oxidation of the drug with the mixture of potassium iodide and potassium iodate to form a yellow colored product. Two methods are adopted for the determination process, the initial rate method...

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Autores principales:	RAZA SIDDIQUI,MASOOM, MOHAMMAD WABAIDUR,SAIKH, AL OTHMAN,ZEID A, ALI,SAJID, ALAM,SARFARAZ
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2014
Materias:	Streptomycin Absorbance Activation parameters Potassium iodate Potassium iodide
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300005
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spelling	oai:scielo:S0717-970720140003000052014-12-15KINETIC SPECTROPHOTOMETRIC METHOD FOR THE QUANTITATIVE ANALYSIS OF STREPTOMYCIN SULFATERAZA SIDDIQUI,MASOOMMOHAMMAD WABAIDUR,SAIKHAL OTHMAN,ZEID AALI,SAJIDALAM,SARFARAZ Streptomycin Absorbance Activation parameters Potassium iodate Potassium iodide Kinetic method has been developed for the quantitative analysis of streptomycin. The method is based on the oxidation of the drug with the mixture of potassium iodide and potassium iodate to form a yellow colored product. Two methods are adopted for the determination process, the initial rate method and fixed time, absorbance difference method. Both the method followed Beer's law in the range of 4 μg ml-1- 72 μg ml-1. The linear regression equation of initial rate and fixed time (absorbance difference) method was evaluated to be Rate (U) = -1.026 x 10-6 + 5.93 x 10-4 C and ΔA = -1.63x10-3 + 8.0x10-3C. The limit of detection of initial rate method and fixed time method was obtained to be 0.011 and 0.50, respectively while limit of quantitation upon calculation came out to be 0.032 and 1.5 for initial rate and fixed time absorbance difference methods, respectively. Another important study in the proposed method is the activation parameter study which was done at four different temperatures i.e 298 K, 303 K, 308 K and 313 K. Using the elevated temperature various activation parameters such as change in enthalpy (Ä H), change in entropy (Δ S) and Gibbs free energy (Δ G) was calculated and obtained to be -34.41 kJ mol-1, -143.16 and -77.0 5 9 x 10³ kJ, respectively Probable mechanism of the reaction has been mentioned in the text.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.59 n.3 20142014-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300005en10.4067/S0717-97072014000300005
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Streptomycin Absorbance Activation parameters Potassium iodate Potassium iodide
spellingShingle	Streptomycin Absorbance Activation parameters Potassium iodate Potassium iodide RAZA SIDDIQUI,MASOOM MOHAMMAD WABAIDUR,SAIKH AL OTHMAN,ZEID A ALI,SAJID ALAM,SARFARAZ KINETIC SPECTROPHOTOMETRIC METHOD FOR THE QUANTITATIVE ANALYSIS OF STREPTOMYCIN SULFATE
description	Kinetic method has been developed for the quantitative analysis of streptomycin. The method is based on the oxidation of the drug with the mixture of potassium iodide and potassium iodate to form a yellow colored product. Two methods are adopted for the determination process, the initial rate method and fixed time, absorbance difference method. Both the method followed Beer's law in the range of 4 μg ml-1- 72 μg ml-1. The linear regression equation of initial rate and fixed time (absorbance difference) method was evaluated to be Rate (U) = -1.026 x 10-6 + 5.93 x 10-4 C and ΔA = -1.63x10-3 + 8.0x10-3C. The limit of detection of initial rate method and fixed time method was obtained to be 0.011 and 0.50, respectively while limit of quantitation upon calculation came out to be 0.032 and 1.5 for initial rate and fixed time absorbance difference methods, respectively. Another important study in the proposed method is the activation parameter study which was done at four different temperatures i.e 298 K, 303 K, 308 K and 313 K. Using the elevated temperature various activation parameters such as change in enthalpy (Ä H), change in entropy (Δ S) and Gibbs free energy (Δ G) was calculated and obtained to be -34.41 kJ mol-1, -143.16 and -77.0 5 9 x 10³ kJ, respectively Probable mechanism of the reaction has been mentioned in the text.
author	RAZA SIDDIQUI,MASOOM MOHAMMAD WABAIDUR,SAIKH AL OTHMAN,ZEID A ALI,SAJID ALAM,SARFARAZ
author_facet	RAZA SIDDIQUI,MASOOM MOHAMMAD WABAIDUR,SAIKH AL OTHMAN,ZEID A ALI,SAJID ALAM,SARFARAZ
author_sort	RAZA SIDDIQUI,MASOOM
title	KINETIC SPECTROPHOTOMETRIC METHOD FOR THE QUANTITATIVE ANALYSIS OF STREPTOMYCIN SULFATE
title_short	KINETIC SPECTROPHOTOMETRIC METHOD FOR THE QUANTITATIVE ANALYSIS OF STREPTOMYCIN SULFATE
title_full	KINETIC SPECTROPHOTOMETRIC METHOD FOR THE QUANTITATIVE ANALYSIS OF STREPTOMYCIN SULFATE
title_fullStr	KINETIC SPECTROPHOTOMETRIC METHOD FOR THE QUANTITATIVE ANALYSIS OF STREPTOMYCIN SULFATE
title_full_unstemmed	KINETIC SPECTROPHOTOMETRIC METHOD FOR THE QUANTITATIVE ANALYSIS OF STREPTOMYCIN SULFATE
title_sort	kinetic spectrophotometric method for the quantitative analysis of streptomycin sulfate
publisher	Sociedad Chilena de Química
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300005
work_keys_str_mv	AT razasiddiquimasoom kineticspectrophotometricmethodforthequantitativeanalysisofstreptomycinsulfate AT mohammadwabaidursaikh kineticspectrophotometricmethodforthequantitativeanalysisofstreptomycinsulfate AT alothmanzeida kineticspectrophotometricmethodforthequantitativeanalysisofstreptomycinsulfate AT alisajid kineticspectrophotometricmethodforthequantitativeanalysisofstreptomycinsulfate AT alamsarfaraz kineticspectrophotometricmethodforthequantitativeanalysisofstreptomycinsulfate
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KINETIC SPECTROPHOTOMETRIC METHOD FOR THE QUANTITATIVE ANALYSIS OF STREPTOMYCIN SULFATE

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