SYNTHESIS, MOLECULAR STRUCTURES, AND ANTIMICROBIAL ACTIVITIES OF N'-(3,5-DIBROMO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDE AND 7V'-(4-DIETHYLAMINO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDE
Two new carbohydrazone derivatives, N'-(3,5-dibromo-2-hydroxybenzylidene)-2-fluorobenzohydrazide (1), and N'-(4-diethylamino-2-hydroxybenzylidene)-2-fluorobenzohydrazide (2), were prepared by the reaction of 2-fluorobenzohydrazide with 3,5-dibromo-2-hydroxybenzaldehyde and 4-diethylamino-2...
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| Autores principales: | , , |
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| Lenguaje: | English |
| Publicado: |
Sociedad Chilena de Química
2014
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| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300006 |
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| Sumario: | Two new carbohydrazone derivatives, N'-(3,5-dibromo-2-hydroxybenzylidene)-2-fluorobenzohydrazide (1), and N'-(4-diethylamino-2-hydroxybenzylidene)-2-fluorobenzohydrazide (2), were prepared by the reaction of 2-fluorobenzohydrazide with 3,5-dibromo-2-hydroxybenzaldehyde and 4-diethylamino-2-hydroxybenzaldehyde, respectively. The compounds were characterized by elemental analyses, infrared spectra, and single crystal X-ray diffraction. The crystal of 1 crystallizes in monoclinic space group C2/c, with unit cell dimensions a = 36.0853(5) Å, b = 10.1711(2) Å, c = 17.3627(5) Å, β = 109.973(2)°, V = 5989.3(2) ų, Z = 16, R1 = 0.0544, wR2 = 0.1300. The crystal of 2 crystallizes in monoclinic space group P2l/c, with unit cell dimensions a = 10.6827(2) Å, b = 16.5256(3) Å, c = 9.8174(1) Å, β = 102.564(2)°, V = 1691.64(5) ų, Z = 4, R1 = 0.0772, wR2 = 0.2156. The compounds were assayed for antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence and Staphylococcus aureus) and antifungal (Aspergillus niger and Candida albicans) activities by MTT method. |
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