SYNTHESIS, MOLECULAR STRUCTURES, AND ANTIMICROBIAL ACTIVITIES OF N'-(3,5-DIBROMO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDE AND 7V'-(4-DIETHYLAMINO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDE

SYNTHESIS, MOLECULAR STRUCTURES, AND ANTIMICROBIAL ACTIVITIES OF N'-(3,5-DIBROMO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDE AND 7V'-(4-DIETHYLAMINO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDE

Two new carbohydrazone derivatives, N'-(3,5-dibromo-2-hydroxybenzylidene)-2-fluorobenzohydrazide (1), and N'-(4-diethylamino-2-hydroxybenzylidene)-2-fluorobenzohydrazide (2), were prepared by the reaction of 2-fluorobenzohydrazide with 3,5-dibromo-2-hydroxybenzaldehyde and 4-diethylamino-2...

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Autores principales: FENG,YUN-XIAO, XUE,LING-WEI, ZHANG,CAI-XIA
Lenguaje:English
Publicado: Sociedad Chilena de Química 2014
Materias:
Synthesis
crystal structure
carbohydrazone
X-ray diffraction
antibacterial activity
antifungal activiy
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300006
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spelling oai:scielo:S0717-970720140003000062014-12-15SYNTHESIS, MOLECULAR STRUCTURES, AND ANTIMICROBIAL ACTIVITIES OF N'-(3,5-DIBROMO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDE AND 7V'-(4-DIETHYLAMINO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDEFENG,YUN-XIAOXUE,LING-WEIZHANG,CAI-XIA Synthesis crystal structure carbohydrazone X-ray diffraction antibacterial activity antifungal activiy Two new carbohydrazone derivatives, N'-(3,5-dibromo-2-hydroxybenzylidene)-2-fluorobenzohydrazide (1), and N'-(4-diethylamino-2-hydroxybenzylidene)-2-fluorobenzohydrazide (2), were prepared by the reaction of 2-fluorobenzohydrazide with 3,5-dibromo-2-hydroxybenzaldehyde and 4-diethylamino-2-hydroxybenzaldehyde, respectively. The compounds were characterized by elemental analyses, infrared spectra, and single crystal X-ray diffraction. The crystal of 1 crystallizes in monoclinic space group C2/c, with unit cell dimensions a = 36.0853(5) Å, b = 10.1711(2) Å, c = 17.3627(5) Å, β = 109.973(2)°, V = 5989.3(2) ų, Z = 16, R1 = 0.0544, wR2 = 0.1300. The crystal of 2 crystallizes in monoclinic space group P2l/c, with unit cell dimensions a = 10.6827(2) Å, b = 16.5256(3) Å, c = 9.8174(1) Å, β = 102.564(2)°, V = 1691.64(5) ų, Z = 4, R1 = 0.0772, wR2 = 0.2156. The compounds were assayed for antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence and Staphylococcus aureus) and antifungal (Aspergillus niger and Candida albicans) activities by MTT method.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.59 n.3 20142014-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300006en10.4067/S0717-97072014000300006
institution Scielo Chile
collection Scielo Chile
language English
topic Synthesis
crystal structure
carbohydrazone
X-ray diffraction
antibacterial activity
antifungal activiy
spellingShingle Synthesis
crystal structure
carbohydrazone
X-ray diffraction
antibacterial activity
antifungal activiy
FENG,YUN-XIAO
XUE,LING-WEI
ZHANG,CAI-XIA
SYNTHESIS, MOLECULAR STRUCTURES, AND ANTIMICROBIAL ACTIVITIES OF N'-(3,5-DIBROMO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDE AND 7V'-(4-DIETHYLAMINO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDE
description Two new carbohydrazone derivatives, N'-(3,5-dibromo-2-hydroxybenzylidene)-2-fluorobenzohydrazide (1), and N'-(4-diethylamino-2-hydroxybenzylidene)-2-fluorobenzohydrazide (2), were prepared by the reaction of 2-fluorobenzohydrazide with 3,5-dibromo-2-hydroxybenzaldehyde and 4-diethylamino-2-hydroxybenzaldehyde, respectively. The compounds were characterized by elemental analyses, infrared spectra, and single crystal X-ray diffraction. The crystal of 1 crystallizes in monoclinic space group C2/c, with unit cell dimensions a = 36.0853(5) Å, b = 10.1711(2) Å, c = 17.3627(5) Å, β = 109.973(2)°, V = 5989.3(2) ų, Z = 16, R1 = 0.0544, wR2 = 0.1300. The crystal of 2 crystallizes in monoclinic space group P2l/c, with unit cell dimensions a = 10.6827(2) Å, b = 16.5256(3) Å, c = 9.8174(1) Å, β = 102.564(2)°, V = 1691.64(5) ų, Z = 4, R1 = 0.0772, wR2 = 0.2156. The compounds were assayed for antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence and Staphylococcus aureus) and antifungal (Aspergillus niger and Candida albicans) activities by MTT method.
author FENG,YUN-XIAO
XUE,LING-WEI
ZHANG,CAI-XIA
author_facet FENG,YUN-XIAO
XUE,LING-WEI
ZHANG,CAI-XIA
author_sort FENG,YUN-XIAO
title SYNTHESIS, MOLECULAR STRUCTURES, AND ANTIMICROBIAL ACTIVITIES OF N'-(3,5-DIBROMO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDE AND 7V'-(4-DIETHYLAMINO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDE
title_short SYNTHESIS, MOLECULAR STRUCTURES, AND ANTIMICROBIAL ACTIVITIES OF N'-(3,5-DIBROMO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDE AND 7V'-(4-DIETHYLAMINO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDE
title_full SYNTHESIS, MOLECULAR STRUCTURES, AND ANTIMICROBIAL ACTIVITIES OF N'-(3,5-DIBROMO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDE AND 7V'-(4-DIETHYLAMINO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDE
title_fullStr SYNTHESIS, MOLECULAR STRUCTURES, AND ANTIMICROBIAL ACTIVITIES OF N'-(3,5-DIBROMO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDE AND 7V'-(4-DIETHYLAMINO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDE
title_full_unstemmed SYNTHESIS, MOLECULAR STRUCTURES, AND ANTIMICROBIAL ACTIVITIES OF N'-(3,5-DIBROMO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDE AND 7V'-(4-DIETHYLAMINO-2-HYDROXYBENZYLIDENE)-2-FLUOROBENZOHYDRAZIDE
title_sort synthesis, molecular structures, and antimicrobial activities of n'-(3,5-dibromo-2-hydroxybenzylidene)-2-fluorobenzohydrazide and 7v'-(4-diethylamino-2-hydroxybenzylidene)-2-fluorobenzohydrazide
publisher Sociedad Chilena de Química
publishDate 2014
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300006
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AT xuelingwei synthesismolecularstructuresandantimicrobialactivitiesofn35dibromo2hydroxybenzylidene2fluorobenzohydrazideand7v4diethylamino2hydroxybenzylidene2fluorobenzohydrazide
AT zhangcaixia synthesismolecularstructuresandantimicrobialactivitiesofn35dibromo2hydroxybenzylidene2fluorobenzohydrazideand7v4diethylamino2hydroxybenzylidene2fluorobenzohydrazide
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