SOTALOL CHIRAL SEPARATION BY CAPILLARY ELECTROPHORESIS

SOTALOL CHIRAL SEPARATION BY CAPILLARY ELECTROPHORESIS

Differences between the pharmaceutical activity among the enantiomers of sotalol are well known, as R-sotalol and S-sotalol have similar antiarrythmic activities but only the R-enantiomer exhibits β-blocking activity. In this study capillary zone electrophoresis was used for the enantiomeri...

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Autores principales: HANCU,GABRIEL, SĂMĂRGHIŢAN,CLAUDIA, RUSU,AURA, MIRCIA,ELEONORA
Lenguaje:English
Publicado: Sociedad Chilena de Química 2014
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300007
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spelling oai:scielo:S0717-970720140003000072014-12-15SOTALOL CHIRAL SEPARATION BY CAPILLARY ELECTROPHORESISHANCU,GABRIELSĂMĂRGHIŢAN,CLAUDIARUSU,AURAMIRCIA,ELEONORADifferences between the pharmaceutical activity among the enantiomers of sotalol are well known, as R-sotalol and S-sotalol have similar antiarrythmic activities but only the R-enantiomer exhibits β-blocking activity. In this study capillary zone electrophoresis was used for the enantiomeric separation of sotalol using different native and derivatized; neutral and charged; cyclodextrines as chiral selectors. The effects of pH value and composition of the background electrolyte, capillary temperature, running voltage and injection parameters have been investigated. The results showed that only the randomly methylated β-cyclodextrine gave a baseline enantiomeric separation under the optimized conditions; chiral interactions being observed also for hydroxypropyl-β-CD and sulfobutyl ether-β-CD. The analytical parameters of the optimized method were verified and the migration order of the two enantiomers was established.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.59 n.3 20142014-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300007en10.4067/S0717-97072014000300007
institution Scielo Chile
collection Scielo Chile
language English
description Differences between the pharmaceutical activity among the enantiomers of sotalol are well known, as R-sotalol and S-sotalol have similar antiarrythmic activities but only the R-enantiomer exhibits β-blocking activity. In this study capillary zone electrophoresis was used for the enantiomeric separation of sotalol using different native and derivatized; neutral and charged; cyclodextrines as chiral selectors. The effects of pH value and composition of the background electrolyte, capillary temperature, running voltage and injection parameters have been investigated. The results showed that only the randomly methylated β-cyclodextrine gave a baseline enantiomeric separation under the optimized conditions; chiral interactions being observed also for hydroxypropyl-β-CD and sulfobutyl ether-β-CD. The analytical parameters of the optimized method were verified and the migration order of the two enantiomers was established.
author HANCU,GABRIEL
SĂMĂRGHIŢAN,CLAUDIA
RUSU,AURA
MIRCIA,ELEONORA
spellingShingle HANCU,GABRIEL
SĂMĂRGHIŢAN,CLAUDIA
RUSU,AURA
MIRCIA,ELEONORA
SOTALOL CHIRAL SEPARATION BY CAPILLARY ELECTROPHORESIS
author_facet HANCU,GABRIEL
SĂMĂRGHIŢAN,CLAUDIA
RUSU,AURA
MIRCIA,ELEONORA
author_sort HANCU,GABRIEL
title SOTALOL CHIRAL SEPARATION BY CAPILLARY ELECTROPHORESIS
title_short SOTALOL CHIRAL SEPARATION BY CAPILLARY ELECTROPHORESIS
title_full SOTALOL CHIRAL SEPARATION BY CAPILLARY ELECTROPHORESIS
title_fullStr SOTALOL CHIRAL SEPARATION BY CAPILLARY ELECTROPHORESIS
title_full_unstemmed SOTALOL CHIRAL SEPARATION BY CAPILLARY ELECTROPHORESIS
title_sort sotalol chiral separation by capillary electrophoresis
publisher Sociedad Chilena de Química
publishDate 2014
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300007
work_keys_str_mv AT hancugabriel sotalolchiralseparationbycapillaryelectrophoresis
AT s258m258rghi354anclaudia sotalolchiralseparationbycapillaryelectrophoresis
AT rusuaura sotalolchiralseparationbycapillaryelectrophoresis
AT mirciaeleonora sotalolchiralseparationbycapillaryelectrophoresis
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