ANTIOXIDANT AND TOXICITY ACTIVITY IN VITRO OF TWELVE SAFROLE DERIVATIVES

The aim of this study was to determine the influence of substituents in aromatic ring and the side chain of safrole on the antioxidant capacity and toxicity of twelve synthetic derivatives of safrole (S1-S12). Each compound was analyzed by two antioxidant methods: DPPH and bleaching of β-ca...

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Autores principales:	MADRID,ALEJANDRO, ESPINOZA,LUIS, PAVÉZ,CATALINA, CARRASCO,HÉCTOR, HIDALGO,MARÍA ELIANA
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2014
Materias:	Safrole derivatives Antioxidant Capacity Phenylpropanoid DPPH b-Carotene
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300015
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spelling	oai:scielo:S0717-970720140003000152014-12-15ANTIOXIDANT AND TOXICITY ACTIVITY IN VITRO OF TWELVE SAFROLE DERIVATIVESMADRID,ALEJANDROESPINOZA,LUISPAVÉZ,CATALINACARRASCO,HÉCTORHIDALGO,MARÍA ELIANA Safrole derivatives Antioxidant Capacity Phenylpropanoid DPPH b-Carotene The aim of this study was to determine the influence of substituents in aromatic ring and the side chain of safrole on the antioxidant capacity and toxicity of twelve synthetic derivatives of safrole (S1-S12). Each compound was analyzed by two antioxidant methods: DPPH and bleaching of β-carotene (DBC). Among the derivates of safrol assayed, S5, S6, S9, S10 and S11 showed the strongest antioxidant capacity: DPPH method, first order specific rate constant (0.0152, 0.0211, 0.0432, 0.0317 and 0.0072) and DBC (22.41 ± 0.13%, 10.71 ± 0.05 %, 9.12 ± 0.89 %, 30.97 ± 0.92 % and 19.08 ± 0.31 %), respectively. The toxicity of the active compounds was evaluated by means of two techniques, Artemia salina, LD50 (4466 ± 1057 ppm, 630 ± 108 ppm, 1513 ± 797 ppm, 1585 ± 317 ppm, 1259 ± 242 ppm) and red cells, Haemolysis (1.58 ± 0.98%, 4.02 ± 2.03%, 8.42 ± 1.38%, 2.59 ± 2.31%, 2.92 ± 0.52%), to provide preliminary information that can be used as a basis for further studies to contribute to the search for new antioxidants.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.59 n.3 20142014-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300015en10.4067/S0717-97072014000300015
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Safrole derivatives Antioxidant Capacity Phenylpropanoid DPPH b-Carotene
spellingShingle	Safrole derivatives Antioxidant Capacity Phenylpropanoid DPPH b-Carotene MADRID,ALEJANDRO ESPINOZA,LUIS PAVÉZ,CATALINA CARRASCO,HÉCTOR HIDALGO,MARÍA ELIANA ANTIOXIDANT AND TOXICITY ACTIVITY IN VITRO OF TWELVE SAFROLE DERIVATIVES
description	The aim of this study was to determine the influence of substituents in aromatic ring and the side chain of safrole on the antioxidant capacity and toxicity of twelve synthetic derivatives of safrole (S1-S12). Each compound was analyzed by two antioxidant methods: DPPH and bleaching of β-carotene (DBC). Among the derivates of safrol assayed, S5, S6, S9, S10 and S11 showed the strongest antioxidant capacity: DPPH method, first order specific rate constant (0.0152, 0.0211, 0.0432, 0.0317 and 0.0072) and DBC (22.41 ± 0.13%, 10.71 ± 0.05 %, 9.12 ± 0.89 %, 30.97 ± 0.92 % and 19.08 ± 0.31 %), respectively. The toxicity of the active compounds was evaluated by means of two techniques, Artemia salina, LD50 (4466 ± 1057 ppm, 630 ± 108 ppm, 1513 ± 797 ppm, 1585 ± 317 ppm, 1259 ± 242 ppm) and red cells, Haemolysis (1.58 ± 0.98%, 4.02 ± 2.03%, 8.42 ± 1.38%, 2.59 ± 2.31%, 2.92 ± 0.52%), to provide preliminary information that can be used as a basis for further studies to contribute to the search for new antioxidants.
author	MADRID,ALEJANDRO ESPINOZA,LUIS PAVÉZ,CATALINA CARRASCO,HÉCTOR HIDALGO,MARÍA ELIANA
author_facet	MADRID,ALEJANDRO ESPINOZA,LUIS PAVÉZ,CATALINA CARRASCO,HÉCTOR HIDALGO,MARÍA ELIANA
author_sort	MADRID,ALEJANDRO
title	ANTIOXIDANT AND TOXICITY ACTIVITY IN VITRO OF TWELVE SAFROLE DERIVATIVES
title_short	ANTIOXIDANT AND TOXICITY ACTIVITY IN VITRO OF TWELVE SAFROLE DERIVATIVES
title_full	ANTIOXIDANT AND TOXICITY ACTIVITY IN VITRO OF TWELVE SAFROLE DERIVATIVES
title_fullStr	ANTIOXIDANT AND TOXICITY ACTIVITY IN VITRO OF TWELVE SAFROLE DERIVATIVES
title_full_unstemmed	ANTIOXIDANT AND TOXICITY ACTIVITY IN VITRO OF TWELVE SAFROLE DERIVATIVES
title_sort	antioxidant and toxicity activity in vitro of twelve safrole derivatives
publisher	Sociedad Chilena de Química
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300015
work_keys_str_mv	AT madridalejandro antioxidantandtoxicityactivityinvitrooftwelvesafrolederivatives AT espinozaluis antioxidantandtoxicityactivityinvitrooftwelvesafrolederivatives AT pavezcatalina antioxidantandtoxicityactivityinvitrooftwelvesafrolederivatives AT carrascohector antioxidantandtoxicityactivityinvitrooftwelvesafrolederivatives AT hidalgomariaeliana antioxidantandtoxicityactivityinvitrooftwelvesafrolederivatives
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ANTIOXIDANT AND TOXICITY ACTIVITY IN VITRO OF TWELVE SAFROLE DERIVATIVES

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