INHIBITION OF QUORUM SENSING BY DRIMANE LACTONES FROM CHILEAN FLORA

Fifteen native Chilean plants were evaluated against the quorum sensing (QS) biosensor AI-1, Chromobacterium violaceum ATCC 12472. Three extracts showed inhibitory activity of QS: Drymis winteri J.R, Psoralea glandulosa L and Peumus boldus. Purification of secondary metabolites from barks of Drimys...

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Autores principales:	CÁRCAMO,GERARDO, SILVA,MARIO, BECERRA,JOSÉ, URRUTIA,HOMERO, SOSSA,KATHERINE, PAZ,CRISTIAN
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2014
Materias:	Quorum sensing Chromobacterium violaceum Drimys winteri Drimane sesquiterpenes
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300021
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id	oai:scielo:S0717-97072014000300021
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spelling	oai:scielo:S0717-970720140003000212014-12-15INHIBITION OF QUORUM SENSING BY DRIMANE LACTONES FROM CHILEAN FLORACÁRCAMO,GERARDOSILVA,MARIOBECERRA,JOSÉURRUTIA,HOMEROSOSSA,KATHERINEPAZ,CRISTIAN Quorum sensing Chromobacterium violaceum Drimys winteri Drimane sesquiterpenes Fifteen native Chilean plants were evaluated against the quorum sensing (QS) biosensor AI-1, Chromobacterium violaceum ATCC 12472. Three extracts showed inhibitory activity of QS: Drymis winteri J.R, Psoralea glandulosa L and Peumus boldus. Purification of secondary metabolites from barks of Drimys winteri showed that drimane sesquiterpenes were the main compounds in the tree. Polygodial, drimenol, isodrimeninol, drimenin, isodrimenin, cinnamolide and valdiviolide were isolated and evaluated in QS inhibition assays. Two α,β unsaturated lactones, cinnamolide and valdiviolide, with the carbonyl on position 12 of the drimane skeleton were found to be inhibitors of QS; other drimane lactones were not active.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.59 n.3 20142014-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300021en10.4067/S0717-97072014000300021
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Quorum sensing Chromobacterium violaceum Drimys winteri Drimane sesquiterpenes
spellingShingle	Quorum sensing Chromobacterium violaceum Drimys winteri Drimane sesquiterpenes CÁRCAMO,GERARDO SILVA,MARIO BECERRA,JOSÉ URRUTIA,HOMERO SOSSA,KATHERINE PAZ,CRISTIAN INHIBITION OF QUORUM SENSING BY DRIMANE LACTONES FROM CHILEAN FLORA
description	Fifteen native Chilean plants were evaluated against the quorum sensing (QS) biosensor AI-1, Chromobacterium violaceum ATCC 12472. Three extracts showed inhibitory activity of QS: Drymis winteri J.R, Psoralea glandulosa L and Peumus boldus. Purification of secondary metabolites from barks of Drimys winteri showed that drimane sesquiterpenes were the main compounds in the tree. Polygodial, drimenol, isodrimeninol, drimenin, isodrimenin, cinnamolide and valdiviolide were isolated and evaluated in QS inhibition assays. Two α,β unsaturated lactones, cinnamolide and valdiviolide, with the carbonyl on position 12 of the drimane skeleton were found to be inhibitors of QS; other drimane lactones were not active.
author	CÁRCAMO,GERARDO SILVA,MARIO BECERRA,JOSÉ URRUTIA,HOMERO SOSSA,KATHERINE PAZ,CRISTIAN
author_facet	CÁRCAMO,GERARDO SILVA,MARIO BECERRA,JOSÉ URRUTIA,HOMERO SOSSA,KATHERINE PAZ,CRISTIAN
author_sort	CÁRCAMO,GERARDO
title	INHIBITION OF QUORUM SENSING BY DRIMANE LACTONES FROM CHILEAN FLORA
title_short	INHIBITION OF QUORUM SENSING BY DRIMANE LACTONES FROM CHILEAN FLORA
title_full	INHIBITION OF QUORUM SENSING BY DRIMANE LACTONES FROM CHILEAN FLORA
title_fullStr	INHIBITION OF QUORUM SENSING BY DRIMANE LACTONES FROM CHILEAN FLORA
title_full_unstemmed	INHIBITION OF QUORUM SENSING BY DRIMANE LACTONES FROM CHILEAN FLORA
title_sort	inhibition of quorum sensing by drimane lactones from chilean flora
publisher	Sociedad Chilena de Química
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000300021
work_keys_str_mv	AT carcamogerardo inhibitionofquorumsensingbydrimanelactonesfromchileanflora AT silvamario inhibitionofquorumsensingbydrimanelactonesfromchileanflora AT becerrajose inhibitionofquorumsensingbydrimanelactonesfromchileanflora AT urrutiahomero inhibitionofquorumsensingbydrimanelactonesfromchileanflora AT sossakatherine inhibitionofquorumsensingbydrimanelactonesfromchileanflora AT pazcristian inhibitionofquorumsensingbydrimanelactonesfromchileanflora
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INHIBITION OF QUORUM SENSING BY DRIMANE LACTONES FROM CHILEAN FLORA

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