A SENSITIVE SEQUENTIAL INJECTION ANALYSIS (SIA) DETERMINATION OF MEMANTINE HYDROCHLORIDE USING LUMINOL-HYDROGEN PEROXIDE INDUCED CHEMILUMINESCENCE DETECTION

A fully automated sequential injection analysis (SIA) method for chemiluminescence (CL) determination of Al-zheimer's drug memantine hydrochloride was developed and presented. The employing of SIA injection analysis facilitates fluidic handling and lowering the consumption of sample and reagent...

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Autores principales:	ALARFAJ,NAWAL A, EL-TOHAMY,MAHA F
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2014
Materias:	Sequential injection analysis Chemiluminescence determination Memantine hydrochloride Pharmaceutical formulations
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000400006
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spelling	oai:scielo:S0717-970720140004000062015-01-09A SENSITIVE SEQUENTIAL INJECTION ANALYSIS (SIA) DETERMINATION OF MEMANTINE HYDROCHLORIDE USING LUMINOL-HYDROGEN PEROXIDE INDUCED CHEMILUMINESCENCE DETECTIONALARFAJ,NAWAL AEL-TOHAMY,MAHA F Sequential injection analysis Chemiluminescence determination Memantine hydrochloride Pharmaceutical formulations A fully automated sequential injection analysis (SIA) method for chemiluminescence (CL) determination of Al-zheimer's drug memantine hydrochloride was developed and presented. The employing of SIA injection analysis facilitates fluidic handling and lowering the consumption of sample and reagents. The basic CL reaction was based on the emission of CL radiation due to the reaction of luminol with hydrogen peroxide in basic medium. The CL emission has been monitored using FIAlab system. The optimum conditions and characterizations were optimized using a computer-aided simplex method. Under the optimal conditions the linear calibration graph was obtained within the range of 0.0001-1.0 μg mL-1, (r=0.9996) with detection limit of 3.3x10-5 μg mL-1 along with relative standard deviation 1.8 % (n). The flow rates were 120 μL s-1, for the aspiration into the holding coil and 80 μL s-1 for detection. The sample frequency throughput was 103 h-1. The proposed CL method was successfully applied for determination of the tested drug in pure form and its pharmaceutical formulations. The interference of some common additive compounds such as glucose, lactose, starch, talc and magnesium stearate was investigated. No interference was recorded. The obtained SIA results were statistically compared with those obtained from a reported method and did not show any significant difference.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.59 n.4 20142014-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000400006en10.4067/S0717-97072014000400006
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Sequential injection analysis Chemiluminescence determination Memantine hydrochloride Pharmaceutical formulations
spellingShingle	Sequential injection analysis Chemiluminescence determination Memantine hydrochloride Pharmaceutical formulations ALARFAJ,NAWAL A EL-TOHAMY,MAHA F A SENSITIVE SEQUENTIAL INJECTION ANALYSIS (SIA) DETERMINATION OF MEMANTINE HYDROCHLORIDE USING LUMINOL-HYDROGEN PEROXIDE INDUCED CHEMILUMINESCENCE DETECTION
description	A fully automated sequential injection analysis (SIA) method for chemiluminescence (CL) determination of Al-zheimer's drug memantine hydrochloride was developed and presented. The employing of SIA injection analysis facilitates fluidic handling and lowering the consumption of sample and reagents. The basic CL reaction was based on the emission of CL radiation due to the reaction of luminol with hydrogen peroxide in basic medium. The CL emission has been monitored using FIAlab system. The optimum conditions and characterizations were optimized using a computer-aided simplex method. Under the optimal conditions the linear calibration graph was obtained within the range of 0.0001-1.0 μg mL-1, (r=0.9996) with detection limit of 3.3x10-5 μg mL-1 along with relative standard deviation 1.8 % (n). The flow rates were 120 μL s-1, for the aspiration into the holding coil and 80 μL s-1 for detection. The sample frequency throughput was 103 h-1. The proposed CL method was successfully applied for determination of the tested drug in pure form and its pharmaceutical formulations. The interference of some common additive compounds such as glucose, lactose, starch, talc and magnesium stearate was investigated. No interference was recorded. The obtained SIA results were statistically compared with those obtained from a reported method and did not show any significant difference.
author	ALARFAJ,NAWAL A EL-TOHAMY,MAHA F
author_facet	ALARFAJ,NAWAL A EL-TOHAMY,MAHA F
author_sort	ALARFAJ,NAWAL A
title	A SENSITIVE SEQUENTIAL INJECTION ANALYSIS (SIA) DETERMINATION OF MEMANTINE HYDROCHLORIDE USING LUMINOL-HYDROGEN PEROXIDE INDUCED CHEMILUMINESCENCE DETECTION
title_short	A SENSITIVE SEQUENTIAL INJECTION ANALYSIS (SIA) DETERMINATION OF MEMANTINE HYDROCHLORIDE USING LUMINOL-HYDROGEN PEROXIDE INDUCED CHEMILUMINESCENCE DETECTION
title_full	A SENSITIVE SEQUENTIAL INJECTION ANALYSIS (SIA) DETERMINATION OF MEMANTINE HYDROCHLORIDE USING LUMINOL-HYDROGEN PEROXIDE INDUCED CHEMILUMINESCENCE DETECTION
title_fullStr	A SENSITIVE SEQUENTIAL INJECTION ANALYSIS (SIA) DETERMINATION OF MEMANTINE HYDROCHLORIDE USING LUMINOL-HYDROGEN PEROXIDE INDUCED CHEMILUMINESCENCE DETECTION
title_full_unstemmed	A SENSITIVE SEQUENTIAL INJECTION ANALYSIS (SIA) DETERMINATION OF MEMANTINE HYDROCHLORIDE USING LUMINOL-HYDROGEN PEROXIDE INDUCED CHEMILUMINESCENCE DETECTION
title_sort	sensitive sequential injection analysis (sia) determination of memantine hydrochloride using luminol-hydrogen peroxide induced chemiluminescence detection
publisher	Sociedad Chilena de Química
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000400006
work_keys_str_mv	AT alarfajnawala asensitivesequentialinjectionanalysissiadeterminationofmemantinehydrochlorideusingluminolhydrogenperoxideinducedchemiluminescencedetection AT eltohamymahaf asensitivesequentialinjectionanalysissiadeterminationofmemantinehydrochlorideusingluminolhydrogenperoxideinducedchemiluminescencedetection AT alarfajnawala sensitivesequentialinjectionanalysissiadeterminationofmemantinehydrochlorideusingluminolhydrogenperoxideinducedchemiluminescencedetection AT eltohamymahaf sensitivesequentialinjectionanalysissiadeterminationofmemantinehydrochlorideusingluminolhydrogenperoxideinducedchemiluminescencedetection
_version_	1718445525832826880

A SENSITIVE SEQUENTIAL INJECTION ANALYSIS (SIA) DETERMINATION OF MEMANTINE HYDROCHLORIDE USING LUMINOL-HYDROGEN PEROXIDE INDUCED CHEMILUMINESCENCE DETECTION

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