SIMULTANEOUS VOLTAMMETRIC DETERMINATION OF N-ACETYL-L-CYSTEINE, URIC ACID AND TRYPTOPHAN AT SURFACE OF GLASSY CARBON ELECTRODE IN THE PRESENT OF 4-CHLOROCATECHOL AS A HOMOGENEOUS ELECTROCHEMICAL CATALYST
Simultaneous determination of N-acetyl-L-cysteine (NAC), uric acid (UA) and tryptophan (Trp) has been studied at the surface of glassy carbon electrode (GCE) in the present of 4-chlorocatechol as a homogenous electrochemical catalyst in aqueous media. The electrocatalytic properties of GCE in the pr...
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Sociedad Chilena de Química
2014
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oai:scielo:S0717-970720140004000132015-01-09SIMULTANEOUS VOLTAMMETRIC DETERMINATION OF N-ACETYL-L-CYSTEINE, URIC ACID AND TRYPTOPHAN AT SURFACE OF GLASSY CARBON ELECTRODE IN THE PRESENT OF 4-CHLOROCATECHOL AS A HOMOGENEOUS ELECTROCHEMICAL CATALYSTJAHANSHAHI,BITARAOOF,JAHANBAKHSHAMIRI-AREF,MOHADDESEHOJANI,REZA N-acetyl-L-cysteine Uric acid Tryptophan 4-Chlorocatechol Simultaneous determination of N-acetyl-L-cysteine (NAC), uric acid (UA) and tryptophan (Trp) has been studied at the surface of glassy carbon electrode (GCE) in the present of 4-chlorocatechol as a homogenous electrochemical catalyst in aqueous media. The electrocatalytic properties of GCE in the present of 4-chlorocatechol toward the electrocatalytic oxidation of NAC, UA and Trp was studied using cyclic voltammetry (CV), double-step potential chronoamperometry and differential pulse voltammetry (DPV). The results show that NAC participates in the reaction with electrogenerated quinone from electrooxidation of 4-chlorocatechol at surface of GCE to form the corresponding thioquinone derivative. The reoxidation of the adduct leads to increase in the oxidative current which is proportional to the concentration of NAC. Differential pulse voltammogram peak currents of NAC, UA and Trp increased linearly with their concentrations in the ranges of 5.0 - 45.0 μM, 10.0 - 50.0 μM and 5.0 - 55.0 μM, respectively and the detection limits for NAC, UA and Trp were sequentially 3.55 μM, 6.96 μM and 4.41 μM. The proposed method was employed for simultaneous determination of NAC, UA and Trp in the pharmaceutical and biological samples and the obtained results were found to be satisfactory.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.59 n.4 20142014-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000400013en10.4067/S0717-97072014000400013 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
N-acetyl-L-cysteine Uric acid Tryptophan 4-Chlorocatechol |
| spellingShingle |
N-acetyl-L-cysteine Uric acid Tryptophan 4-Chlorocatechol JAHANSHAHI,BITA RAOOF,JAHANBAKHSH AMIRI-AREF,MOHADDESEH OJANI,REZA SIMULTANEOUS VOLTAMMETRIC DETERMINATION OF N-ACETYL-L-CYSTEINE, URIC ACID AND TRYPTOPHAN AT SURFACE OF GLASSY CARBON ELECTRODE IN THE PRESENT OF 4-CHLOROCATECHOL AS A HOMOGENEOUS ELECTROCHEMICAL CATALYST |
| description |
Simultaneous determination of N-acetyl-L-cysteine (NAC), uric acid (UA) and tryptophan (Trp) has been studied at the surface of glassy carbon electrode (GCE) in the present of 4-chlorocatechol as a homogenous electrochemical catalyst in aqueous media. The electrocatalytic properties of GCE in the present of 4-chlorocatechol toward the electrocatalytic oxidation of NAC, UA and Trp was studied using cyclic voltammetry (CV), double-step potential chronoamperometry and differential pulse voltammetry (DPV). The results show that NAC participates in the reaction with electrogenerated quinone from electrooxidation of 4-chlorocatechol at surface of GCE to form the corresponding thioquinone derivative. The reoxidation of the adduct leads to increase in the oxidative current which is proportional to the concentration of NAC. Differential pulse voltammogram peak currents of NAC, UA and Trp increased linearly with their concentrations in the ranges of 5.0 - 45.0 μM, 10.0 - 50.0 μM and 5.0 - 55.0 μM, respectively and the detection limits for NAC, UA and Trp were sequentially 3.55 μM, 6.96 μM and 4.41 μM. The proposed method was employed for simultaneous determination of NAC, UA and Trp in the pharmaceutical and biological samples and the obtained results were found to be satisfactory. |
| author |
JAHANSHAHI,BITA RAOOF,JAHANBAKHSH AMIRI-AREF,MOHADDESEH OJANI,REZA |
| author_facet |
JAHANSHAHI,BITA RAOOF,JAHANBAKHSH AMIRI-AREF,MOHADDESEH OJANI,REZA |
| author_sort |
JAHANSHAHI,BITA |
| title |
SIMULTANEOUS VOLTAMMETRIC DETERMINATION OF N-ACETYL-L-CYSTEINE, URIC ACID AND TRYPTOPHAN AT SURFACE OF GLASSY CARBON ELECTRODE IN THE PRESENT OF 4-CHLOROCATECHOL AS A HOMOGENEOUS ELECTROCHEMICAL CATALYST |
| title_short |
SIMULTANEOUS VOLTAMMETRIC DETERMINATION OF N-ACETYL-L-CYSTEINE, URIC ACID AND TRYPTOPHAN AT SURFACE OF GLASSY CARBON ELECTRODE IN THE PRESENT OF 4-CHLOROCATECHOL AS A HOMOGENEOUS ELECTROCHEMICAL CATALYST |
| title_full |
SIMULTANEOUS VOLTAMMETRIC DETERMINATION OF N-ACETYL-L-CYSTEINE, URIC ACID AND TRYPTOPHAN AT SURFACE OF GLASSY CARBON ELECTRODE IN THE PRESENT OF 4-CHLOROCATECHOL AS A HOMOGENEOUS ELECTROCHEMICAL CATALYST |
| title_fullStr |
SIMULTANEOUS VOLTAMMETRIC DETERMINATION OF N-ACETYL-L-CYSTEINE, URIC ACID AND TRYPTOPHAN AT SURFACE OF GLASSY CARBON ELECTRODE IN THE PRESENT OF 4-CHLOROCATECHOL AS A HOMOGENEOUS ELECTROCHEMICAL CATALYST |
| title_full_unstemmed |
SIMULTANEOUS VOLTAMMETRIC DETERMINATION OF N-ACETYL-L-CYSTEINE, URIC ACID AND TRYPTOPHAN AT SURFACE OF GLASSY CARBON ELECTRODE IN THE PRESENT OF 4-CHLOROCATECHOL AS A HOMOGENEOUS ELECTROCHEMICAL CATALYST |
| title_sort |
simultaneous voltammetric determination of n-acetyl-l-cysteine, uric acid and tryptophan at surface of glassy carbon electrode in the present of 4-chlorocatechol as a homogeneous electrochemical catalyst |
| publisher |
Sociedad Chilena de Química |
| publishDate |
2014 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072014000400013 |
| work_keys_str_mv |
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| _version_ |
1718445527115235328 |