STUDIES ON THE ALKYLATION OF QUINOLIN-2(1H)-ONE DERIVATIVES
Alkylation of quinolin-2(1H)-one (1) and its C(6) and C(7) substituted dervatives (OMe, OBn, and Cl) with 2-bromoacetophenone or chloroacetone under basic condition (K2CO3 in DMF) gave a mixture of N1- and O2- alkylated products with the former one as a major product. However, alkylation of 8-methox...
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| Lenguaje: | English |
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Sociedad Chilena de Química
2015
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oai:scielo:S0717-970720150001000082015-04-21STUDIES ON THE ALKYLATION OF QUINOLIN-2(1H)-ONE DERIVATIVESCHEN,CHIA-LINGCHEN,I-LICHEN,JIH-JUNGWEI,DAU-CHANGHSIEH,HAN-JIECHANG,KEN-MINGTZENG,CHERNG-CHYIWANG,TAI-CHI N-Alkylation O-Alkylation Quinolin-2(1H)-one Alkylation of quinolin-2(1H)-one (1) and its C(6) and C(7) substituted dervatives (OMe, OBn, and Cl) with 2-bromoacetophenone or chloroacetone under basic condition (K2CO3 in DMF) gave a mixture of N1- and O2- alkylated products with the former one as a major product. However, alkylation of 8-methoxy-, 8-benzyloxy-, and 8-chloro- quinolin-2(1H)-ones under the same reaction conditions gave exclusively O2-alkylated products.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.60 n.1 20152015-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000100008en10.4067/S0717-97072015000100008 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
N-Alkylation O-Alkylation Quinolin-2(1H)-one |
| spellingShingle |
N-Alkylation O-Alkylation Quinolin-2(1H)-one CHEN,CHIA-LING CHEN,I-LI CHEN,JIH-JUNG WEI,DAU-CHANG HSIEH,HAN-JIE CHANG,KEN-MING TZENG,CHERNG-CHYI WANG,TAI-CHI STUDIES ON THE ALKYLATION OF QUINOLIN-2(1H)-ONE DERIVATIVES |
| description |
Alkylation of quinolin-2(1H)-one (1) and its C(6) and C(7) substituted dervatives (OMe, OBn, and Cl) with 2-bromoacetophenone or chloroacetone under basic condition (K2CO3 in DMF) gave a mixture of N1- and O2- alkylated products with the former one as a major product. However, alkylation of 8-methoxy-, 8-benzyloxy-, and 8-chloro- quinolin-2(1H)-ones under the same reaction conditions gave exclusively O2-alkylated products. |
| author |
CHEN,CHIA-LING CHEN,I-LI CHEN,JIH-JUNG WEI,DAU-CHANG HSIEH,HAN-JIE CHANG,KEN-MING TZENG,CHERNG-CHYI WANG,TAI-CHI |
| author_facet |
CHEN,CHIA-LING CHEN,I-LI CHEN,JIH-JUNG WEI,DAU-CHANG HSIEH,HAN-JIE CHANG,KEN-MING TZENG,CHERNG-CHYI WANG,TAI-CHI |
| author_sort |
CHEN,CHIA-LING |
| title |
STUDIES ON THE ALKYLATION OF QUINOLIN-2(1H)-ONE DERIVATIVES |
| title_short |
STUDIES ON THE ALKYLATION OF QUINOLIN-2(1H)-ONE DERIVATIVES |
| title_full |
STUDIES ON THE ALKYLATION OF QUINOLIN-2(1H)-ONE DERIVATIVES |
| title_fullStr |
STUDIES ON THE ALKYLATION OF QUINOLIN-2(1H)-ONE DERIVATIVES |
| title_full_unstemmed |
STUDIES ON THE ALKYLATION OF QUINOLIN-2(1H)-ONE DERIVATIVES |
| title_sort |
studies on the alkylation of quinolin-2(1h)-one derivatives |
| publisher |
Sociedad Chilena de Química |
| publishDate |
2015 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000100008 |
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