AN EFFICIENT AND GREEN PROTOCOL FOR THE SYNTHESIS OF DIHYDROPYRANO [2,3-C] PYRAZOLES IN AQUEOUS MEDIUM USING THIAMINE HYDROCHLORIDE AS A CATALYST

A green and expedient approach for the synthesis of dihydropyrano[2,3-c] pyrazoles via four-component reaction of ethyl acetoacetate, hydrazine hydrate, aromatic aldehydes and malononitrile at room temperature under ultrasound irradiation is described. The reaction has been catalyzed by thiamine hyd...

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Autores principales:	NIKAM,MUKESH D, MAHAJAN,PRAVINS, CHATE,ASHA V, DABHADE,SANJAYK, GILL,CHARANSINGHH
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2015
Materias:	Multicomponent reaction Dihydropyrano[2,3-c]pyrazoles Green chemistry Aqueous medium Ultrasound irradiation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000100016
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spelling	oai:scielo:S0717-970720150001000162015-04-21AN EFFICIENT AND GREEN PROTOCOL FOR THE SYNTHESIS OF DIHYDROPYRANO [2,3-C] PYRAZOLES IN AQUEOUS MEDIUM USING THIAMINE HYDROCHLORIDE AS A CATALYSTNIKAM,MUKESH DMAHAJAN,PRAVINSCHATE,ASHA VDABHADE,SANJAYKGILL,CHARANSINGHH Multicomponent reaction Dihydropyrano[2,3-c]pyrazoles Green chemistry Aqueous medium Ultrasound irradiation A green and expedient approach for the synthesis of dihydropyrano[2,3-c] pyrazoles via four-component reaction of ethyl acetoacetate, hydrazine hydrate, aromatic aldehydes and malononitrile at room temperature under ultrasound irradiation is described. The reaction has been catalyzed by thiamine hydrochloride in aqueous medium. This protocol afforded several advantages such as inexpensive, easily available catalyst, simple operational procedure, excellent yield, use of aqueous medium and ultrasound irradiation that is considered to be relatively eco-friendly.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.60 n.1 20152015-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000100016en10.4067/S0717-97072015000100016
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Multicomponent reaction Dihydropyrano[2,3-c]pyrazoles Green chemistry Aqueous medium Ultrasound irradiation
spellingShingle	Multicomponent reaction Dihydropyrano[2,3-c]pyrazoles Green chemistry Aqueous medium Ultrasound irradiation NIKAM,MUKESH D MAHAJAN,PRAVINS CHATE,ASHA V DABHADE,SANJAYK GILL,CHARANSINGHH AN EFFICIENT AND GREEN PROTOCOL FOR THE SYNTHESIS OF DIHYDROPYRANO [2,3-C] PYRAZOLES IN AQUEOUS MEDIUM USING THIAMINE HYDROCHLORIDE AS A CATALYST
description	A green and expedient approach for the synthesis of dihydropyrano[2,3-c] pyrazoles via four-component reaction of ethyl acetoacetate, hydrazine hydrate, aromatic aldehydes and malononitrile at room temperature under ultrasound irradiation is described. The reaction has been catalyzed by thiamine hydrochloride in aqueous medium. This protocol afforded several advantages such as inexpensive, easily available catalyst, simple operational procedure, excellent yield, use of aqueous medium and ultrasound irradiation that is considered to be relatively eco-friendly.
author	NIKAM,MUKESH D MAHAJAN,PRAVINS CHATE,ASHA V DABHADE,SANJAYK GILL,CHARANSINGHH
author_facet	NIKAM,MUKESH D MAHAJAN,PRAVINS CHATE,ASHA V DABHADE,SANJAYK GILL,CHARANSINGHH
author_sort	NIKAM,MUKESH D
title	AN EFFICIENT AND GREEN PROTOCOL FOR THE SYNTHESIS OF DIHYDROPYRANO [2,3-C] PYRAZOLES IN AQUEOUS MEDIUM USING THIAMINE HYDROCHLORIDE AS A CATALYST
title_short	AN EFFICIENT AND GREEN PROTOCOL FOR THE SYNTHESIS OF DIHYDROPYRANO [2,3-C] PYRAZOLES IN AQUEOUS MEDIUM USING THIAMINE HYDROCHLORIDE AS A CATALYST
title_full	AN EFFICIENT AND GREEN PROTOCOL FOR THE SYNTHESIS OF DIHYDROPYRANO [2,3-C] PYRAZOLES IN AQUEOUS MEDIUM USING THIAMINE HYDROCHLORIDE AS A CATALYST
title_fullStr	AN EFFICIENT AND GREEN PROTOCOL FOR THE SYNTHESIS OF DIHYDROPYRANO [2,3-C] PYRAZOLES IN AQUEOUS MEDIUM USING THIAMINE HYDROCHLORIDE AS A CATALYST
title_full_unstemmed	AN EFFICIENT AND GREEN PROTOCOL FOR THE SYNTHESIS OF DIHYDROPYRANO [2,3-C] PYRAZOLES IN AQUEOUS MEDIUM USING THIAMINE HYDROCHLORIDE AS A CATALYST
title_sort	efficient and green protocol for the synthesis of dihydropyrano [2,3-c] pyrazoles in aqueous medium using thiamine hydrochloride as a catalyst
publisher	Sociedad Chilena de Química
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000100016
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AN EFFICIENT AND GREEN PROTOCOL FOR THE SYNTHESIS OF DIHYDROPYRANO [2,3-C] PYRAZOLES IN AQUEOUS MEDIUM USING THIAMINE HYDROCHLORIDE AS A CATALYST

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