SYNTHESIS AND ANTI-MICROBIAL ACTIVITIES OF 1,3,5-TRISUBSTITUTED-PYRAZOLE DERIVATIVES CONTAINING A PYRIDYL MOIETY

Claisen condensation of ethyl isonicotinate with different acetophenones gave the corresponding pyridyl-ß-diketones, while the treatment with hydrazine hydrate yielded 3,5-disubstituted-1H-pyrazoles, which then converted 1,3,5-trisubstituted-pyrazole derivatives containing a pyridyl moiety by N-acyl...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	WANG,DUN-JIA, LIU,HUA, KANG,YAN-FANG, HU,YAN-JUN, WEI,XIAN-HONG
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2015
Materias:	1,3,5-Trisubstituted-pyrazole ß-Diketone Synthesis, Anti-microbial activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000100018
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-97072015000100018
record_format	dspace
spelling	oai:scielo:S0717-970720150001000182015-04-21SYNTHESIS AND ANTI-MICROBIAL ACTIVITIES OF 1,3,5-TRISUBSTITUTED-PYRAZOLE DERIVATIVES CONTAINING A PYRIDYL MOIETYWANG,DUN-JIALIU,HUAKANG,YAN-FANGHU,YAN-JUNWEI,XIAN-HONG 1,3,5-Trisubstituted-pyrazole ß-Diketone Synthesis, Anti-microbial activity Claisen condensation of ethyl isonicotinate with different acetophenones gave the corresponding pyridyl-ß-diketones, while the treatment with hydrazine hydrate yielded 3,5-disubstituted-1H-pyrazoles, which then converted 1,3,5-trisubstituted-pyrazole derivatives containing a pyridyl moiety by N-acylation with acyl chloride. The structures of all newly synthesized compounds are established by FTIR, ¹H NMR, mass spectroscopy and elemental analysis, and in the case of compound 2e, analyzed by single-crystal X-ray diffraction further. The anti-microbial activities of the title compounds have been tested by disc diffusion method against Escherichia coli, Staphylococcus aureus, Pyricularia oryzae and Rhizoctnia solani. The results showed that compounds 3c and 4c exhibited good inhibitory activity against all the tested organisms.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.60 n.1 20152015-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000100018en10.4067/S0717-97072015000100018
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	1,3,5-Trisubstituted-pyrazole ß-Diketone Synthesis, Anti-microbial activity
spellingShingle	1,3,5-Trisubstituted-pyrazole ß-Diketone Synthesis, Anti-microbial activity WANG,DUN-JIA LIU,HUA KANG,YAN-FANG HU,YAN-JUN WEI,XIAN-HONG SYNTHESIS AND ANTI-MICROBIAL ACTIVITIES OF 1,3,5-TRISUBSTITUTED-PYRAZOLE DERIVATIVES CONTAINING A PYRIDYL MOIETY
description	Claisen condensation of ethyl isonicotinate with different acetophenones gave the corresponding pyridyl-ß-diketones, while the treatment with hydrazine hydrate yielded 3,5-disubstituted-1H-pyrazoles, which then converted 1,3,5-trisubstituted-pyrazole derivatives containing a pyridyl moiety by N-acylation with acyl chloride. The structures of all newly synthesized compounds are established by FTIR, ¹H NMR, mass spectroscopy and elemental analysis, and in the case of compound 2e, analyzed by single-crystal X-ray diffraction further. The anti-microbial activities of the title compounds have been tested by disc diffusion method against Escherichia coli, Staphylococcus aureus, Pyricularia oryzae and Rhizoctnia solani. The results showed that compounds 3c and 4c exhibited good inhibitory activity against all the tested organisms.
author	WANG,DUN-JIA LIU,HUA KANG,YAN-FANG HU,YAN-JUN WEI,XIAN-HONG
author_facet	WANG,DUN-JIA LIU,HUA KANG,YAN-FANG HU,YAN-JUN WEI,XIAN-HONG
author_sort	WANG,DUN-JIA
title	SYNTHESIS AND ANTI-MICROBIAL ACTIVITIES OF 1,3,5-TRISUBSTITUTED-PYRAZOLE DERIVATIVES CONTAINING A PYRIDYL MOIETY
title_short	SYNTHESIS AND ANTI-MICROBIAL ACTIVITIES OF 1,3,5-TRISUBSTITUTED-PYRAZOLE DERIVATIVES CONTAINING A PYRIDYL MOIETY
title_full	SYNTHESIS AND ANTI-MICROBIAL ACTIVITIES OF 1,3,5-TRISUBSTITUTED-PYRAZOLE DERIVATIVES CONTAINING A PYRIDYL MOIETY
title_fullStr	SYNTHESIS AND ANTI-MICROBIAL ACTIVITIES OF 1,3,5-TRISUBSTITUTED-PYRAZOLE DERIVATIVES CONTAINING A PYRIDYL MOIETY
title_full_unstemmed	SYNTHESIS AND ANTI-MICROBIAL ACTIVITIES OF 1,3,5-TRISUBSTITUTED-PYRAZOLE DERIVATIVES CONTAINING A PYRIDYL MOIETY
title_sort	synthesis and anti-microbial activities of 1,3,5-trisubstituted-pyrazole derivatives containing a pyridyl moiety
publisher	Sociedad Chilena de Química
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000100018
work_keys_str_mv	AT wangdunjia synthesisandantimicrobialactivitiesof135trisubstitutedpyrazolederivativescontainingapyridylmoiety AT liuhua synthesisandantimicrobialactivitiesof135trisubstitutedpyrazolederivativescontainingapyridylmoiety AT kangyanfang synthesisandantimicrobialactivitiesof135trisubstitutedpyrazolederivativescontainingapyridylmoiety AT huyanjun synthesisandantimicrobialactivitiesof135trisubstitutedpyrazolederivativescontainingapyridylmoiety AT weixianhong synthesisandantimicrobialactivitiesof135trisubstitutedpyrazolederivativescontainingapyridylmoiety
_version_	1718445532438855680

SYNTHESIS AND ANTI-MICROBIAL ACTIVITIES OF 1,3,5-TRISUBSTITUTED-PYRAZOLE DERIVATIVES CONTAINING A PYRIDYL MOIETY

Ejemplares similares