SYNTHESIS, STRUCTURES AND ANTIMICROBIAL ACTIVITY OF CHLORO- AND FLUORO-SUBSTITUTED THIOCARBOXYHYDRAZONES
A series of chloro- and fluoro-substituted thiocarboxyhydrazones, 2-(2-chlorobenzylidene)-N-methylhydrazinecarbothioamide (1), 2-(4-fluorobenzylidene)-N-methylhydrazinecarbothioamide (2), and 2-(2-chloro-4-fluorobenzylidene)-N-methylhydrazinecarbothioamide (3), were synthesized and characterized by...
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| Lenguaje: | English |
| Publicado: |
Sociedad Chilena de Química
2015
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| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000200002 |
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| Sumario: | A series of chloro- and fluoro-substituted thiocarboxyhydrazones, 2-(2-chlorobenzylidene)-N-methylhydrazinecarbothioamide (1), 2-(4-fluorobenzylidene)-N-methylhydrazinecarbothioamide (2), and 2-(2-chloro-4-fluorobenzylidene)-N-methylhydrazinecarbothioamide (3), were synthesized and characterized by elemental analysis, IR and UV-vis spectra, and single crystal X-ray diffraction. Structures of the three compounds are similar, but with slight modification by chloro- and fluoro-substitute groups. The crystal structures of the compounds are stabilized by hydrogen bonds and π···π interactions. The antimicrobial activity of the compounds shows that they are effective against some bacteria. |
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