SYNTHESIS, STRUCTURES AND ANTIMICROBIAL ACTIVITY OF CHLORO- AND FLUORO-SUBSTITUTED THIOCARBOXYHYDRAZONES

SYNTHESIS, STRUCTURES AND ANTIMICROBIAL ACTIVITY OF CHLORO- AND FLUORO-SUBSTITUTED THIOCARBOXYHYDRAZONES

A series of chloro- and fluoro-substituted thiocarboxyhydrazones, 2-(2-chlorobenzylidene)-N-methylhydrazinecarbothioamide (1), 2-(4-fluorobenzylidene)-N-methylhydrazinecarbothioamide (2), and 2-(2-chloro-4-fluorobenzylidene)-N-methylhydrazinecarbothioamide (3), were synthesized and characterized by...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autor principal: LIU,ZENG-XIN
Lenguaje:English
Publicado: Sociedad Chilena de Química 2015
Materias:
thiocarboxyhydrazones
antimicrobial activity
crystal structure
hydrogen bonding
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000200002
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:scielo:S0717-97072015000200002
record_format dspace
spelling oai:scielo:S0717-970720150002000022019-10-08SYNTHESIS, STRUCTURES AND ANTIMICROBIAL ACTIVITY OF CHLORO- AND FLUORO-SUBSTITUTED THIOCARBOXYHYDRAZONESLIU,ZENG-XIN thiocarboxyhydrazones antimicrobial activity crystal structure hydrogen bonding A series of chloro- and fluoro-substituted thiocarboxyhydrazones, 2-(2-chlorobenzylidene)-N-methylhydrazinecarbothioamide (1), 2-(4-fluorobenzylidene)-N-methylhydrazinecarbothioamide (2), and 2-(2-chloro-4-fluorobenzylidene)-N-methylhydrazinecarbothioamide (3), were synthesized and characterized by elemental analysis, IR and UV-vis spectra, and single crystal X-ray diffraction. Structures of the three compounds are similar, but with slight modification by chloro- and fluoro-substitute groups. The crystal structures of the compounds are stabilized by hydrogen bonds and π···π interactions. The antimicrobial activity of the compounds shows that they are effective against some bacteria.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.60 n.2 20152015-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000200002en10.4067/S0717-97072015000200002
institution Scielo Chile
collection Scielo Chile
language English
topic thiocarboxyhydrazones
antimicrobial activity
crystal structure
hydrogen bonding
spellingShingle thiocarboxyhydrazones
antimicrobial activity
crystal structure
hydrogen bonding
LIU,ZENG-XIN
SYNTHESIS, STRUCTURES AND ANTIMICROBIAL ACTIVITY OF CHLORO- AND FLUORO-SUBSTITUTED THIOCARBOXYHYDRAZONES
description A series of chloro- and fluoro-substituted thiocarboxyhydrazones, 2-(2-chlorobenzylidene)-N-methylhydrazinecarbothioamide (1), 2-(4-fluorobenzylidene)-N-methylhydrazinecarbothioamide (2), and 2-(2-chloro-4-fluorobenzylidene)-N-methylhydrazinecarbothioamide (3), were synthesized and characterized by elemental analysis, IR and UV-vis spectra, and single crystal X-ray diffraction. Structures of the three compounds are similar, but with slight modification by chloro- and fluoro-substitute groups. The crystal structures of the compounds are stabilized by hydrogen bonds and π···π interactions. The antimicrobial activity of the compounds shows that they are effective against some bacteria.
author LIU,ZENG-XIN
author_facet LIU,ZENG-XIN
author_sort LIU,ZENG-XIN
title SYNTHESIS, STRUCTURES AND ANTIMICROBIAL ACTIVITY OF CHLORO- AND FLUORO-SUBSTITUTED THIOCARBOXYHYDRAZONES
title_short SYNTHESIS, STRUCTURES AND ANTIMICROBIAL ACTIVITY OF CHLORO- AND FLUORO-SUBSTITUTED THIOCARBOXYHYDRAZONES
title_full SYNTHESIS, STRUCTURES AND ANTIMICROBIAL ACTIVITY OF CHLORO- AND FLUORO-SUBSTITUTED THIOCARBOXYHYDRAZONES
title_fullStr SYNTHESIS, STRUCTURES AND ANTIMICROBIAL ACTIVITY OF CHLORO- AND FLUORO-SUBSTITUTED THIOCARBOXYHYDRAZONES
title_full_unstemmed SYNTHESIS, STRUCTURES AND ANTIMICROBIAL ACTIVITY OF CHLORO- AND FLUORO-SUBSTITUTED THIOCARBOXYHYDRAZONES
title_sort synthesis, structures and antimicrobial activity of chloro- and fluoro-substituted thiocarboxyhydrazones
publisher Sociedad Chilena de Química
publishDate 2015
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000200002
work_keys_str_mv AT liuzengxin synthesisstructuresandantimicrobialactivityofchloroandfluorosubstitutedthiocarboxyhydrazones
_version_ 1718445533337485312

Ejemplares similares