CYTOTOXIC AND ANTIMICROBIAL ACTIVITIES OF TWO NEW TRITERPENOIDS FROM THE PEELS OF LOCAL EGYPTIAN MALUS DOMESTICA L.

CYTOTOXIC AND ANTIMICROBIAL ACTIVITIES OF TWO NEW TRITERPENOIDS FROM THE PEELS OF LOCAL EGYPTIAN MALUS DOMESTICA L.

The local Egyptian peels of Malus domestica was extracted successively with absolute ethanol and partitioned sequentially with n-hexane, chloroform and methanol. Friedelin (1) was isolated from the n-hexane fraction, and betulinic acid (2) from the chloroform fraction. The new compounds 2α-...

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Autores principales: SELM,Y. A, LITINAS,K. E
Lenguaje:English
Publicado: Sociedad Chilena de Química 2015
Materias:
Malus domestica
triterpenoids
plant extraction
betulinic acid
Cytotoxicity
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000200007
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spelling oai:scielo:S0717-970720150002000072019-10-08CYTOTOXIC AND ANTIMICROBIAL ACTIVITIES OF TWO NEW TRITERPENOIDS FROM THE PEELS OF LOCAL EGYPTIAN MALUS DOMESTICA L.SELM,Y. ALITINAS,K. E Malus domestica triterpenoids plant extraction betulinic acid Cytotoxicity The local Egyptian peels of Malus domestica was extracted successively with absolute ethanol and partitioned sequentially with n-hexane, chloroform and methanol. Friedelin (1) was isolated from the n-hexane fraction, and betulinic acid (2) from the chloroform fraction. The new compounds 2α-hydorxy-3-oxo-lup-12(13), 20(29)-dien-27, 28-dioic acid (3) and 2α, 27-dihydorxy-3-oxo-lup-12(13), 20(29)-dien-28-oic acid (4) were isolated from the methanol fraction and elucidated by spectroscopic data interpretation. Friedelin (1) and betulinic acid (2) are known compounds that are newly identified from peels of Malus domestica. The compounds 3 & 4 are appreciably active against Gram-positive species and Gram-negative species, associated with week anti-fungal activity. Among them, compounds (3) and (4) exhibited cytotoxic activity against the breast carcinoma and human colon carcinoma cells, with (4) being slightly most potent toward to the breast carcinoma while, (3) being slightly most potent toward to the human colon carcinoma cells .info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.60 n.2 20152015-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000200007en10.4067/S0717-97072015000200007
institution Scielo Chile
collection Scielo Chile
language English
topic Malus domestica
triterpenoids
plant extraction
betulinic acid
Cytotoxicity
spellingShingle Malus domestica
triterpenoids
plant extraction
betulinic acid
Cytotoxicity
SELM,Y. A
LITINAS,K. E
CYTOTOXIC AND ANTIMICROBIAL ACTIVITIES OF TWO NEW TRITERPENOIDS FROM THE PEELS OF LOCAL EGYPTIAN MALUS DOMESTICA L.
description The local Egyptian peels of Malus domestica was extracted successively with absolute ethanol and partitioned sequentially with n-hexane, chloroform and methanol. Friedelin (1) was isolated from the n-hexane fraction, and betulinic acid (2) from the chloroform fraction. The new compounds 2α-hydorxy-3-oxo-lup-12(13), 20(29)-dien-27, 28-dioic acid (3) and 2α, 27-dihydorxy-3-oxo-lup-12(13), 20(29)-dien-28-oic acid (4) were isolated from the methanol fraction and elucidated by spectroscopic data interpretation. Friedelin (1) and betulinic acid (2) are known compounds that are newly identified from peels of Malus domestica. The compounds 3 & 4 are appreciably active against Gram-positive species and Gram-negative species, associated with week anti-fungal activity. Among them, compounds (3) and (4) exhibited cytotoxic activity against the breast carcinoma and human colon carcinoma cells, with (4) being slightly most potent toward to the breast carcinoma while, (3) being slightly most potent toward to the human colon carcinoma cells .
author SELM,Y. A
LITINAS,K. E
author_facet SELM,Y. A
LITINAS,K. E
author_sort SELM,Y. A
title CYTOTOXIC AND ANTIMICROBIAL ACTIVITIES OF TWO NEW TRITERPENOIDS FROM THE PEELS OF LOCAL EGYPTIAN MALUS DOMESTICA L.
title_short CYTOTOXIC AND ANTIMICROBIAL ACTIVITIES OF TWO NEW TRITERPENOIDS FROM THE PEELS OF LOCAL EGYPTIAN MALUS DOMESTICA L.
title_full CYTOTOXIC AND ANTIMICROBIAL ACTIVITIES OF TWO NEW TRITERPENOIDS FROM THE PEELS OF LOCAL EGYPTIAN MALUS DOMESTICA L.
title_fullStr CYTOTOXIC AND ANTIMICROBIAL ACTIVITIES OF TWO NEW TRITERPENOIDS FROM THE PEELS OF LOCAL EGYPTIAN MALUS DOMESTICA L.
title_full_unstemmed CYTOTOXIC AND ANTIMICROBIAL ACTIVITIES OF TWO NEW TRITERPENOIDS FROM THE PEELS OF LOCAL EGYPTIAN MALUS DOMESTICA L.
title_sort cytotoxic and antimicrobial activities of two new triterpenoids from the peels of local egyptian malus domestica l.
publisher Sociedad Chilena de Química
publishDate 2015
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000200007
work_keys_str_mv AT selmya cytotoxicandantimicrobialactivitiesoftwonewtriterpenoidsfromthepeelsoflocalegyptianmalusdomestical
AT litinaske cytotoxicandantimicrobialactivitiesoftwonewtriterpenoidsfromthepeelsoflocalegyptianmalusdomestical
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