SYNTHESIS AND ANTIOXIDANT EVALUATION OF NOVEL PHENOTHIAZINE LINKED SUBSTITUTEDBENZYLIDENEAMINO-1,2,4-TRIAZOLE DERIVATIVES

A series of novel 5-((10H-phenothiazin-10yl)methyl)-4-(substitutedbenzylideneamino)-4H-1,2,4-triazole-3-thiol derivatives (6a-i) have been synthesized from compound (1) through a multi-step reaction. The key intermediate (5) afforded a series of title compounds (6a-i) on condensation with various su...

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Autores principales:	MADDILA,SURESH, MOMIN,MEHBUB, GORLE,SRIDEVI, PALAKONDU,LAVANYA, JONNALAGADDA,SREEKANTH B
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2015
Materias:	Synthesis Anti-oxidant activity 1,2,4-Triazole Phenothiazines
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000200012
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spelling	oai:scielo:S0717-970720150002000122019-10-08SYNTHESIS AND ANTIOXIDANT EVALUATION OF NOVEL PHENOTHIAZINE LINKED SUBSTITUTEDBENZYLIDENEAMINO-1,2,4-TRIAZOLE DERIVATIVESMADDILA,SURESHMOMIN,MEHBUBGORLE,SRIDEVIPALAKONDU,LAVANYAJONNALAGADDA,SREEKANTH B Synthesis Anti-oxidant activity 1,2,4-Triazole Phenothiazines A series of novel 5-((10H-phenothiazin-10yl)methyl)-4-(substitutedbenzylideneamino)-4H-1,2,4-triazole-3-thiol derivatives (6a-i) have been synthesized from compound (1) through a multi-step reaction. The key intermediate (5) afforded a series of title compounds (6a-i) on condensation with various suitable aldehydes in the presence of H2SO4. The structures of novel compounds were characterized based on their elemental analysis, IR, ¹H-NMR, 13C-NMR and MS spectral data. All these novel compounds were screened for their in vitro antioxidant activity by employing nitric oxide, hydrogen peroxide, and DPPH radical scavenging assays. The compounds 6d, 6e and 6i demonstrated potent antioxidant activity as these contain the electron-releasing groups.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.60 n.2 20152015-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000200012en10.4067/S0717-97072015000200012
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Synthesis Anti-oxidant activity 1,2,4-Triazole Phenothiazines
spellingShingle	Synthesis Anti-oxidant activity 1,2,4-Triazole Phenothiazines MADDILA,SURESH MOMIN,MEHBUB GORLE,SRIDEVI PALAKONDU,LAVANYA JONNALAGADDA,SREEKANTH B SYNTHESIS AND ANTIOXIDANT EVALUATION OF NOVEL PHENOTHIAZINE LINKED SUBSTITUTEDBENZYLIDENEAMINO-1,2,4-TRIAZOLE DERIVATIVES
description	A series of novel 5-((10H-phenothiazin-10yl)methyl)-4-(substitutedbenzylideneamino)-4H-1,2,4-triazole-3-thiol derivatives (6a-i) have been synthesized from compound (1) through a multi-step reaction. The key intermediate (5) afforded a series of title compounds (6a-i) on condensation with various suitable aldehydes in the presence of H2SO4. The structures of novel compounds were characterized based on their elemental analysis, IR, ¹H-NMR, 13C-NMR and MS spectral data. All these novel compounds were screened for their in vitro antioxidant activity by employing nitric oxide, hydrogen peroxide, and DPPH radical scavenging assays. The compounds 6d, 6e and 6i demonstrated potent antioxidant activity as these contain the electron-releasing groups.
author	MADDILA,SURESH MOMIN,MEHBUB GORLE,SRIDEVI PALAKONDU,LAVANYA JONNALAGADDA,SREEKANTH B
author_facet	MADDILA,SURESH MOMIN,MEHBUB GORLE,SRIDEVI PALAKONDU,LAVANYA JONNALAGADDA,SREEKANTH B
author_sort	MADDILA,SURESH
title	SYNTHESIS AND ANTIOXIDANT EVALUATION OF NOVEL PHENOTHIAZINE LINKED SUBSTITUTEDBENZYLIDENEAMINO-1,2,4-TRIAZOLE DERIVATIVES
title_short	SYNTHESIS AND ANTIOXIDANT EVALUATION OF NOVEL PHENOTHIAZINE LINKED SUBSTITUTEDBENZYLIDENEAMINO-1,2,4-TRIAZOLE DERIVATIVES
title_full	SYNTHESIS AND ANTIOXIDANT EVALUATION OF NOVEL PHENOTHIAZINE LINKED SUBSTITUTEDBENZYLIDENEAMINO-1,2,4-TRIAZOLE DERIVATIVES
title_fullStr	SYNTHESIS AND ANTIOXIDANT EVALUATION OF NOVEL PHENOTHIAZINE LINKED SUBSTITUTEDBENZYLIDENEAMINO-1,2,4-TRIAZOLE DERIVATIVES
title_full_unstemmed	SYNTHESIS AND ANTIOXIDANT EVALUATION OF NOVEL PHENOTHIAZINE LINKED SUBSTITUTEDBENZYLIDENEAMINO-1,2,4-TRIAZOLE DERIVATIVES
title_sort	synthesis and antioxidant evaluation of novel phenothiazine linked substitutedbenzylideneamino-1,2,4-triazole derivatives
publisher	Sociedad Chilena de Química
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000200012
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SYNTHESIS AND ANTIOXIDANT EVALUATION OF NOVEL PHENOTHIAZINE LINKED SUBSTITUTEDBENZYLIDENEAMINO-1,2,4-TRIAZOLE DERIVATIVES

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