SYNTHESIS, CRYSTAL STRUCTURES, AND ANTIBACTERIAL ACTIVITY OF A SERIES OF HYDRAZONE COMPOUNDS DERIVED FROM 4-METHYLBENZOHYDRAZIDE

SYNTHESIS, CRYSTAL STRUCTURES, AND ANTIBACTERIAL ACTIVITY OF A SERIES OF HYDRAZONE COMPOUNDS DERIVED FROM 4-METHYLBENZOHYDRAZIDE

A series of hydrazone compounds, 4-methyl-N'-(4-nitrobenzylidene)benzohydrazide methanol solvate (1), N'-(4-hydroxy-3-nitrobenzylidene)-4-methylbenzohydrazide dimethanol solvate (2), and N'-(3,5-dibromobenzylidene)-4-methylbenzohydrazide (3), derived from 4-methylbenzohydrazide with d...

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Bibliographic Details
Main Authors: LEI,YAN, Li,TING-ZHEN, FU,CHUAN, GUAN,XIAO-LIN, TAN,YAO
Language:English
Published: Sociedad Chilena de Química 2015
Subjects:
Synthesis
crystal structure
hydrazone compound
hydrogen bonding
antibacterial activity
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000200021
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Summary:A series of hydrazone compounds, 4-methyl-N'-(4-nitrobenzylidene)benzohydrazide methanol solvate (1), N'-(4-hydroxy-3-nitrobenzylidene)-4-methylbenzohydrazide dimethanol solvate (2), and N'-(3,5-dibromobenzylidene)-4-methylbenzohydrazide (3), derived from 4-methylbenzohydrazide with different benzaldehydes, were synthesized and characterized by physico-chemical methods and single crystal X-ray diffraction. Crystals of the compounds are stabilized by intermolecular hydrogen bonds, as well as π···π stacking interactions. Antibacterial activity of the compounds against Staphylococcus aureus, Escherichia coli, and Klebsielle pneumoniae strains was studied. Compounds 1 and 2 have moderate minimum inhibition concentration values on the tested bacteria strains. Compound 3, with the Br-substituent groups, showed the highest activity on the bacterial strains.

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