SYNTHESIS, CRYSTAL STRUCTURES, AND ANTIBACTERIAL ACTIVITY OF A SERIES OF HYDRAZONE COMPOUNDS DERIVED FROM 4-METHYLBENZOHYDRAZIDE

A series of hydrazone compounds, 4-methyl-N'-(4-nitrobenzylidene)benzohydrazide methanol solvate (1), N'-(4-hydroxy-3-nitrobenzylidene)-4-methylbenzohydrazide dimethanol solvate (2), and N'-(3,5-dibromobenzylidene)-4-methylbenzohydrazide (3), derived from 4-methylbenzohydrazide with d...

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Autores principales:	LEI,YAN, Li,TING-ZHEN, FU,CHUAN, GUAN,XIAO-LIN, TAN,YAO
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2015
Materias:	Synthesis crystal structure hydrazone compound hydrogen bonding antibacterial activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000200021
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spelling	oai:scielo:S0717-970720150002000212019-10-08SYNTHESIS, CRYSTAL STRUCTURES, AND ANTIBACTERIAL ACTIVITY OF A SERIES OF HYDRAZONE COMPOUNDS DERIVED FROM 4-METHYLBENZOHYDRAZIDELEI,YANLi,TING-ZHENFU,CHUANGUAN,XIAO-LINTAN,YAO Synthesis crystal structure hydrazone compound hydrogen bonding antibacterial activity A series of hydrazone compounds, 4-methyl-N'-(4-nitrobenzylidene)benzohydrazide methanol solvate (1), N'-(4-hydroxy-3-nitrobenzylidene)-4-methylbenzohydrazide dimethanol solvate (2), and N'-(3,5-dibromobenzylidene)-4-methylbenzohydrazide (3), derived from 4-methylbenzohydrazide with different benzaldehydes, were synthesized and characterized by physico-chemical methods and single crystal X-ray diffraction. Crystals of the compounds are stabilized by intermolecular hydrogen bonds, as well as π···π stacking interactions. Antibacterial activity of the compounds against Staphylococcus aureus, Escherichia coli, and Klebsielle pneumoniae strains was studied. Compounds 1 and 2 have moderate minimum inhibition concentration values on the tested bacteria strains. Compound 3, with the Br-substituent groups, showed the highest activity on the bacterial strains.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.60 n.2 20152015-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000200021en10.4067/S0717-97072015000200021
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Synthesis crystal structure hydrazone compound hydrogen bonding antibacterial activity
spellingShingle	Synthesis crystal structure hydrazone compound hydrogen bonding antibacterial activity LEI,YAN Li,TING-ZHEN FU,CHUAN GUAN,XIAO-LIN TAN,YAO SYNTHESIS, CRYSTAL STRUCTURES, AND ANTIBACTERIAL ACTIVITY OF A SERIES OF HYDRAZONE COMPOUNDS DERIVED FROM 4-METHYLBENZOHYDRAZIDE
description	A series of hydrazone compounds, 4-methyl-N'-(4-nitrobenzylidene)benzohydrazide methanol solvate (1), N'-(4-hydroxy-3-nitrobenzylidene)-4-methylbenzohydrazide dimethanol solvate (2), and N'-(3,5-dibromobenzylidene)-4-methylbenzohydrazide (3), derived from 4-methylbenzohydrazide with different benzaldehydes, were synthesized and characterized by physico-chemical methods and single crystal X-ray diffraction. Crystals of the compounds are stabilized by intermolecular hydrogen bonds, as well as π···π stacking interactions. Antibacterial activity of the compounds against Staphylococcus aureus, Escherichia coli, and Klebsielle pneumoniae strains was studied. Compounds 1 and 2 have moderate minimum inhibition concentration values on the tested bacteria strains. Compound 3, with the Br-substituent groups, showed the highest activity on the bacterial strains.
author	LEI,YAN Li,TING-ZHEN FU,CHUAN GUAN,XIAO-LIN TAN,YAO
author_facet	LEI,YAN Li,TING-ZHEN FU,CHUAN GUAN,XIAO-LIN TAN,YAO
author_sort	LEI,YAN
title	SYNTHESIS, CRYSTAL STRUCTURES, AND ANTIBACTERIAL ACTIVITY OF A SERIES OF HYDRAZONE COMPOUNDS DERIVED FROM 4-METHYLBENZOHYDRAZIDE
title_short	SYNTHESIS, CRYSTAL STRUCTURES, AND ANTIBACTERIAL ACTIVITY OF A SERIES OF HYDRAZONE COMPOUNDS DERIVED FROM 4-METHYLBENZOHYDRAZIDE
title_full	SYNTHESIS, CRYSTAL STRUCTURES, AND ANTIBACTERIAL ACTIVITY OF A SERIES OF HYDRAZONE COMPOUNDS DERIVED FROM 4-METHYLBENZOHYDRAZIDE
title_fullStr	SYNTHESIS, CRYSTAL STRUCTURES, AND ANTIBACTERIAL ACTIVITY OF A SERIES OF HYDRAZONE COMPOUNDS DERIVED FROM 4-METHYLBENZOHYDRAZIDE
title_full_unstemmed	SYNTHESIS, CRYSTAL STRUCTURES, AND ANTIBACTERIAL ACTIVITY OF A SERIES OF HYDRAZONE COMPOUNDS DERIVED FROM 4-METHYLBENZOHYDRAZIDE
title_sort	synthesis, crystal structures, and antibacterial activity of a series of hydrazone compounds derived from 4-methylbenzohydrazide
publisher	Sociedad Chilena de Química
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000200021
work_keys_str_mv	AT leiyan synthesiscrystalstructuresandantibacterialactivityofaseriesofhydrazonecompoundsderivedfrom4methylbenzohydrazide AT litingzhen synthesiscrystalstructuresandantibacterialactivityofaseriesofhydrazonecompoundsderivedfrom4methylbenzohydrazide AT fuchuan synthesiscrystalstructuresandantibacterialactivityofaseriesofhydrazonecompoundsderivedfrom4methylbenzohydrazide AT guanxiaolin synthesiscrystalstructuresandantibacterialactivityofaseriesofhydrazonecompoundsderivedfrom4methylbenzohydrazide AT tanyao synthesiscrystalstructuresandantibacterialactivityofaseriesofhydrazonecompoundsderivedfrom4methylbenzohydrazide
_version_	1718445536735920128

SYNTHESIS, CRYSTAL STRUCTURES, AND ANTIBACTERIAL ACTIVITY OF A SERIES OF HYDRAZONE COMPOUNDS DERIVED FROM 4-METHYLBENZOHYDRAZIDE

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