ANTIMUTAGENIC AND ANTIOXIDANT POTENTIAL OF AQUEOUS AND ACIDIFIED METHANOL EXTRACTS FROM CITRUS LIMONUM FRUIT RESIDUES

Aqueous and acidified methanol extracts from C. limonum fruit residues (CLFR) were evaluated for their total phenolic contents, antioxidant and antimutagenic activities. Total phenolic contents (TPC) of aqueous (30% and 70%) and acidified (0.5 N and 1.0 N) methanol extracts from CLFR were estimated...

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Autores principales:	MUSHTAQ,MUHAMMAD, SULTANA,BUSHRA, ANWAR,FAROOQ, BATOOL,SIDRA
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2015
Materias:	Citrus fruit Hydrolysis phenolic bioactives antioxidants antimutagenics
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000200024
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spelling	oai:scielo:S0717-970720150002000242019-10-08ANTIMUTAGENIC AND ANTIOXIDANT POTENTIAL OF AQUEOUS AND ACIDIFIED METHANOL EXTRACTS FROM CITRUS LIMONUM FRUIT RESIDUESMUSHTAQ,MUHAMMADSULTANA,BUSHRAANWAR,FAROOQBATOOL,SIDRA Citrus fruit Hydrolysis phenolic bioactives antioxidants antimutagenics Aqueous and acidified methanol extracts from C. limonum fruit residues (CLFR) were evaluated for their total phenolic contents, antioxidant and antimutagenic activities. Total phenolic contents (TPC) of aqueous (30% and 70%) and acidified (0.5 N and 1.0 N) methanol extracts from CLFR were estimated by Folin-Ciocalteu reagent method whereas in-vitro antioxidant activity was assessed calorimetrically by measuring DPPH* scavenging capacity and inhibition of linoleic acid peroxidation. Anti-mutagenic potential of the extracts was appraised by Ames bacterial reverse mutation test. TPC, DPPH° scavenging capacity and inhibition of linoleic acid peroxidation were varied from 27.75-126.35 mg gallic acid equivalent (GAE)/g DW, 46-91%, and 34-83%, respectively. All the tested extracts of CLFR noticeably hunted mutagens (16.47-55.69 %) whereas none of these caused mutagenesis. Overall, acidified methanol extracts from CLFR exhibited higher extraction yields, TPC, inhibition of peroxidation and DPPH radical scavenging activity among others indicating a significant (p<0.05) variation of these attributes in relation to residue samples and extraction media. The results support that CLFR (peel and pulp biomass) being a rich source of phenolic antimutagens, can be explored as a potential candidate for the development of natural chemo-preventive drugs and nutracueticals.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.60 n.2 20152015-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000200024en10.4067/S0717-97072015000200025
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Citrus fruit Hydrolysis phenolic bioactives antioxidants antimutagenics
spellingShingle	Citrus fruit Hydrolysis phenolic bioactives antioxidants antimutagenics MUSHTAQ,MUHAMMAD SULTANA,BUSHRA ANWAR,FAROOQ BATOOL,SIDRA ANTIMUTAGENIC AND ANTIOXIDANT POTENTIAL OF AQUEOUS AND ACIDIFIED METHANOL EXTRACTS FROM CITRUS LIMONUM FRUIT RESIDUES
description	Aqueous and acidified methanol extracts from C. limonum fruit residues (CLFR) were evaluated for their total phenolic contents, antioxidant and antimutagenic activities. Total phenolic contents (TPC) of aqueous (30% and 70%) and acidified (0.5 N and 1.0 N) methanol extracts from CLFR were estimated by Folin-Ciocalteu reagent method whereas in-vitro antioxidant activity was assessed calorimetrically by measuring DPPH* scavenging capacity and inhibition of linoleic acid peroxidation. Anti-mutagenic potential of the extracts was appraised by Ames bacterial reverse mutation test. TPC, DPPH° scavenging capacity and inhibition of linoleic acid peroxidation were varied from 27.75-126.35 mg gallic acid equivalent (GAE)/g DW, 46-91%, and 34-83%, respectively. All the tested extracts of CLFR noticeably hunted mutagens (16.47-55.69 %) whereas none of these caused mutagenesis. Overall, acidified methanol extracts from CLFR exhibited higher extraction yields, TPC, inhibition of peroxidation and DPPH radical scavenging activity among others indicating a significant (p<0.05) variation of these attributes in relation to residue samples and extraction media. The results support that CLFR (peel and pulp biomass) being a rich source of phenolic antimutagens, can be explored as a potential candidate for the development of natural chemo-preventive drugs and nutracueticals.
author	MUSHTAQ,MUHAMMAD SULTANA,BUSHRA ANWAR,FAROOQ BATOOL,SIDRA
author_facet	MUSHTAQ,MUHAMMAD SULTANA,BUSHRA ANWAR,FAROOQ BATOOL,SIDRA
author_sort	MUSHTAQ,MUHAMMAD
title	ANTIMUTAGENIC AND ANTIOXIDANT POTENTIAL OF AQUEOUS AND ACIDIFIED METHANOL EXTRACTS FROM CITRUS LIMONUM FRUIT RESIDUES
title_short	ANTIMUTAGENIC AND ANTIOXIDANT POTENTIAL OF AQUEOUS AND ACIDIFIED METHANOL EXTRACTS FROM CITRUS LIMONUM FRUIT RESIDUES
title_full	ANTIMUTAGENIC AND ANTIOXIDANT POTENTIAL OF AQUEOUS AND ACIDIFIED METHANOL EXTRACTS FROM CITRUS LIMONUM FRUIT RESIDUES
title_fullStr	ANTIMUTAGENIC AND ANTIOXIDANT POTENTIAL OF AQUEOUS AND ACIDIFIED METHANOL EXTRACTS FROM CITRUS LIMONUM FRUIT RESIDUES
title_full_unstemmed	ANTIMUTAGENIC AND ANTIOXIDANT POTENTIAL OF AQUEOUS AND ACIDIFIED METHANOL EXTRACTS FROM CITRUS LIMONUM FRUIT RESIDUES
title_sort	antimutagenic and antioxidant potential of aqueous and acidified methanol extracts from citrus limonum fruit residues
publisher	Sociedad Chilena de Química
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000200024
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ANTIMUTAGENIC AND ANTIOXIDANT POTENTIAL OF AQUEOUS AND ACIDIFIED METHANOL EXTRACTS FROM CITRUS LIMONUM FRUIT RESIDUES

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