KINETICS AND MECHANISTIC STUDY OF OXIDATION OF AMOXICILLIN BY CHLORAMINE-T IN ACID MEDIUM

This spectroscopic study presents the kinetics and degradation pathways of oxidation of amoxicillin (AMOX) by chloramines-T (CAT) in acidic medium at a constant ionic strength of 0.105 mol dm-3 at 298 K. Reaction between AMOX and CAT in acidic medium exhibits 1:1 stoichiometry (AMOX:CAT). The reacti...

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Autores principales:	VEENA,M. S, PRASHANTH,M. K, YOGESH KUMAR,K, MURALIDHARA,H. B, ARTHOBA NAYAKA,Y
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2015
Materias:	Amoxicillin Chloramines-T Kinetics Mechanistic Oxidation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000300019
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spelling	oai:scielo:S0717-970720150003000192015-12-04KINETICS AND MECHANISTIC STUDY OF OXIDATION OF AMOXICILLIN BY CHLORAMINE-T IN ACID MEDIUMVEENA,M. SPRASHANTH,M. KYOGESH KUMAR,KMURALIDHARA,H. BARTHOBA NAYAKA,Y Amoxicillin Chloramines-T Kinetics Mechanistic Oxidation This spectroscopic study presents the kinetics and degradation pathways of oxidation of amoxicillin (AMOX) by chloramines-T (CAT) in acidic medium at a constant ionic strength of 0.105 mol dm-3 at 298 K. Reaction between AMOX and CAT in acidic medium exhibits 1:1 stoichiometry (AMOX:CAT). The reaction is of a first-order in both [CAT] and [AMOX]. The order with respect to acid concentration was fractional. The effects of added products, ionic strength and dielectric constant have been studied. The main oxidation product of AMOX was identified by IR, ¹H NMR and mass spectra. The reaction constants involved in the different steps of the mechanisms were calculated. Activation parameters with respect to slow step of the mechanisms were computed and discussed.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.60 n.3 20152015-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000300019en10.4067/S0717-97072015000300019
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Amoxicillin Chloramines-T Kinetics Mechanistic Oxidation
spellingShingle	Amoxicillin Chloramines-T Kinetics Mechanistic Oxidation VEENA,M. S PRASHANTH,M. K YOGESH KUMAR,K MURALIDHARA,H. B ARTHOBA NAYAKA,Y KINETICS AND MECHANISTIC STUDY OF OXIDATION OF AMOXICILLIN BY CHLORAMINE-T IN ACID MEDIUM
description	This spectroscopic study presents the kinetics and degradation pathways of oxidation of amoxicillin (AMOX) by chloramines-T (CAT) in acidic medium at a constant ionic strength of 0.105 mol dm-3 at 298 K. Reaction between AMOX and CAT in acidic medium exhibits 1:1 stoichiometry (AMOX:CAT). The reaction is of a first-order in both [CAT] and [AMOX]. The order with respect to acid concentration was fractional. The effects of added products, ionic strength and dielectric constant have been studied. The main oxidation product of AMOX was identified by IR, ¹H NMR and mass spectra. The reaction constants involved in the different steps of the mechanisms were calculated. Activation parameters with respect to slow step of the mechanisms were computed and discussed.
author	VEENA,M. S PRASHANTH,M. K YOGESH KUMAR,K MURALIDHARA,H. B ARTHOBA NAYAKA,Y
author_facet	VEENA,M. S PRASHANTH,M. K YOGESH KUMAR,K MURALIDHARA,H. B ARTHOBA NAYAKA,Y
author_sort	VEENA,M. S
title	KINETICS AND MECHANISTIC STUDY OF OXIDATION OF AMOXICILLIN BY CHLORAMINE-T IN ACID MEDIUM
title_short	KINETICS AND MECHANISTIC STUDY OF OXIDATION OF AMOXICILLIN BY CHLORAMINE-T IN ACID MEDIUM
title_full	KINETICS AND MECHANISTIC STUDY OF OXIDATION OF AMOXICILLIN BY CHLORAMINE-T IN ACID MEDIUM
title_fullStr	KINETICS AND MECHANISTIC STUDY OF OXIDATION OF AMOXICILLIN BY CHLORAMINE-T IN ACID MEDIUM
title_full_unstemmed	KINETICS AND MECHANISTIC STUDY OF OXIDATION OF AMOXICILLIN BY CHLORAMINE-T IN ACID MEDIUM
title_sort	kinetics and mechanistic study of oxidation of amoxicillin by chloramine-t in acid medium
publisher	Sociedad Chilena de Química
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000300019
work_keys_str_mv	AT veenams kineticsandmechanisticstudyofoxidationofamoxicillinbychloraminetinacidmedium AT prashanthmk kineticsandmechanisticstudyofoxidationofamoxicillinbychloraminetinacidmedium AT yogeshkumark kineticsandmechanisticstudyofoxidationofamoxicillinbychloraminetinacidmedium AT muralidharahb kineticsandmechanisticstudyofoxidationofamoxicillinbychloraminetinacidmedium AT arthobanayakay kineticsandmechanisticstudyofoxidationofamoxicillinbychloraminetinacidmedium
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KINETICS AND MECHANISTIC STUDY OF OXIDATION OF AMOXICILLIN BY CHLORAMINE-T IN ACID MEDIUM

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