RAPID METHOD OF FRIEDEL-CRAFTS ALKYLATION OF PHLOROGLUCINOL BY MICROWAVE IN DRY MEDIA AND REUSABLE CATALYST

A new rapid and efficient method for the synthesis of a series of alkylated phloroglucinols using conventional microwave is reported 4 phloroglucinol derivatives (4, 5, 6 and 7) were synthesized with good yields (~50%) by a Friedel-Crafts reaction through an Electrophilic Aromatic Substitution mecha...

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Main Authors: VERGARA,ALEJANDRA P, CONTRERAS,JAVIER A, OSORIO,MAURICIO E, CARVAJAL,MARCELA A
Language:English
Published: Sociedad Chilena de Química 2015
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Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000300020
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Summary:A new rapid and efficient method for the synthesis of a series of alkylated phloroglucinols using conventional microwave is reported 4 phloroglucinol derivatives (4, 5, 6 and 7) were synthesized with good yields (~50%) by a Friedel-Crafts reaction through an Electrophilic Aromatic Substitution mechanism between geraniol/prenol and phloroglucinol, using reusable SiO2 and AgNO3 as the best catalyst tested without solvents under microwave irradiation.