INVESTIGATED THE SUPRAMOLECULAR INTERACTION OF TRAMADOL HYDROCHLORIDE WITH P-SULFONATED CALIX[4,6,8]ARENE

In this paper, the interaction behavior of p-sulfonated calix[n]arene (SCnA) with tramadol hydrochloride was investigated by fluorescence spectra, ¹H NMR spectra, and theoretical calculations in aqueous solution. At the optimized conditions, the fluorescence intensity of tramadol hydrochloride showe...

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Autores principales:	ZHAO,QING-HUA, CHEN,CAI-PING, PANG,TAO-TAO, DU,LI-MING, LI,YAN, XIE,JIAN-HONG, FU,YUN-LONG
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2015
Materias:	Tramadol hydrochloride Spectrofluorometry Supramolecular interaction p-sulfonated calyx[n]arene
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000400007
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spelling	oai:scielo:S0717-970720150004000072016-02-23INVESTIGATED THE SUPRAMOLECULAR INTERACTION OF TRAMADOL HYDROCHLORIDE WITH P-SULFONATED CALIX[4,6,8]ARENEZHAO,QING-HUACHEN,CAI-PINGPANG,TAO-TAODU,LI-MINGLI,YANXIE,JIAN-HONGFU,YUN-LONG Tramadol hydrochloride Spectrofluorometry Supramolecular interaction p-sulfonated calyx[n]arene In this paper, the interaction behavior of p-sulfonated calix[n]arene (SCnA) with tramadol hydrochloride was investigated by fluorescence spectra, ¹H NMR spectra, and theoretical calculations in aqueous solution. At the optimized conditions, the fluorescence intensity of tramadol hydrochloride showed positive correlation to the concentration of SCnA, which led to a validated, simple, and sensitive fluorescence quenching method for the determination of tramadol hydrochloride was established for the first time. Moreover, the interaction based on SCnA superstructure provided has promising potential for therapeutic monitoring and pharmacokinetics and clinical applicationinfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.60 n.4 20152015-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000400007en10.4067/S0717-97072015000400007
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Tramadol hydrochloride Spectrofluorometry Supramolecular interaction p-sulfonated calyx[n]arene
spellingShingle	Tramadol hydrochloride Spectrofluorometry Supramolecular interaction p-sulfonated calyx[n]arene ZHAO,QING-HUA CHEN,CAI-PING PANG,TAO-TAO DU,LI-MING LI,YAN XIE,JIAN-HONG FU,YUN-LONG INVESTIGATED THE SUPRAMOLECULAR INTERACTION OF TRAMADOL HYDROCHLORIDE WITH P-SULFONATED CALIX[4,6,8]ARENE
description	In this paper, the interaction behavior of p-sulfonated calix[n]arene (SCnA) with tramadol hydrochloride was investigated by fluorescence spectra, ¹H NMR spectra, and theoretical calculations in aqueous solution. At the optimized conditions, the fluorescence intensity of tramadol hydrochloride showed positive correlation to the concentration of SCnA, which led to a validated, simple, and sensitive fluorescence quenching method for the determination of tramadol hydrochloride was established for the first time. Moreover, the interaction based on SCnA superstructure provided has promising potential for therapeutic monitoring and pharmacokinetics and clinical application
author	ZHAO,QING-HUA CHEN,CAI-PING PANG,TAO-TAO DU,LI-MING LI,YAN XIE,JIAN-HONG FU,YUN-LONG
author_facet	ZHAO,QING-HUA CHEN,CAI-PING PANG,TAO-TAO DU,LI-MING LI,YAN XIE,JIAN-HONG FU,YUN-LONG
author_sort	ZHAO,QING-HUA
title	INVESTIGATED THE SUPRAMOLECULAR INTERACTION OF TRAMADOL HYDROCHLORIDE WITH P-SULFONATED CALIX[4,6,8]ARENE
title_short	INVESTIGATED THE SUPRAMOLECULAR INTERACTION OF TRAMADOL HYDROCHLORIDE WITH P-SULFONATED CALIX[4,6,8]ARENE
title_full	INVESTIGATED THE SUPRAMOLECULAR INTERACTION OF TRAMADOL HYDROCHLORIDE WITH P-SULFONATED CALIX[4,6,8]ARENE
title_fullStr	INVESTIGATED THE SUPRAMOLECULAR INTERACTION OF TRAMADOL HYDROCHLORIDE WITH P-SULFONATED CALIX[4,6,8]ARENE
title_full_unstemmed	INVESTIGATED THE SUPRAMOLECULAR INTERACTION OF TRAMADOL HYDROCHLORIDE WITH P-SULFONATED CALIX[4,6,8]ARENE
title_sort	investigated the supramolecular interaction of tramadol hydrochloride with p-sulfonated calix[4,6,8]arene
publisher	Sociedad Chilena de Química
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000400007
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INVESTIGATED THE SUPRAMOLECULAR INTERACTION OF TRAMADOL HYDROCHLORIDE WITH P-SULFONATED CALIX[4,6,8]ARENE

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