ANTIBACTERIAL AND ENZYME INHIBITION SCREENING OF SOME NEW ACETAMIDE AND AZOMETHINE DERIVATIVES

The synthesis of poly-functional moieties as one unit has been under consideration by the synthetic chemists to search out new potent molecules. 2-Chlorobenzoic acid (1) was converted to 5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-thiol (4) through a series of steps. This nucleophile was attached with diff...

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Autores principales:	RASOOL,SHAHID, AZIZ-UR-REHMAN, ABBASI,MUHAMMAD ATHAR, SIDDIQUI,SABAHAT ZAHRA, SHAH,SYED ADNAN ALI, AHMAD,IRSHAD, AFZAL,SAIRA
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2015
Materias:	1,3,4-Oxadiazole 2-chlorobenzoic acid acetamides antibacterial activity enzyme inhibition activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000400014
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spelling	oai:scielo:S0717-970720150004000142016-02-23ANTIBACTERIAL AND ENZYME INHIBITION SCREENING OF SOME NEW ACETAMIDE AND AZOMETHINE DERIVATIVESRASOOL,SHAHIDAZIZ-UR-REHMAN,ABBASI,MUHAMMAD ATHARSIDDIQUI,SABAHAT ZAHRASHAH,SYED ADNAN ALIAHMAD,IRSHADAFZAL,SAIRA 1,3,4-Oxadiazole 2-chlorobenzoic acid acetamides antibacterial activity enzyme inhibition activity The synthesis of poly-functional moieties as one unit has been under consideration by the synthetic chemists to search out new potent molecules. 2-Chlorobenzoic acid (1) was converted to 5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-thiol (4) through a series of steps. This nucleophile was attached with different electrophiles, prepared by the reaction of aryl/alkyl amines with 2-bromoacetylbromide, in NaH/DMF to synthesize N-substituted-2-((5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-yl)sulfanyl)acetamide, 7a-f. The molecule 4 was stepped to ethyl ester and carbohydrazide. The carbohydrazide was made to react with aryl carboxaldehydes in methanol to synthesize N'-substituted-2-(5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-ylthio)acetohydrazide, 11a-i. The structures of all the molecules were corroborated through IR, ¹H-NMR and EI-MS spectral data. Both the series were screened for antibacterial and enzyme inhibition activity.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.60 n.4 20152015-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000400014en10.4067/S0717-97072015000400014
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	1,3,4-Oxadiazole 2-chlorobenzoic acid acetamides antibacterial activity enzyme inhibition activity
spellingShingle	1,3,4-Oxadiazole 2-chlorobenzoic acid acetamides antibacterial activity enzyme inhibition activity RASOOL,SHAHID AZIZ-UR-REHMAN, ABBASI,MUHAMMAD ATHAR SIDDIQUI,SABAHAT ZAHRA SHAH,SYED ADNAN ALI AHMAD,IRSHAD AFZAL,SAIRA ANTIBACTERIAL AND ENZYME INHIBITION SCREENING OF SOME NEW ACETAMIDE AND AZOMETHINE DERIVATIVES
description	The synthesis of poly-functional moieties as one unit has been under consideration by the synthetic chemists to search out new potent molecules. 2-Chlorobenzoic acid (1) was converted to 5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-thiol (4) through a series of steps. This nucleophile was attached with different electrophiles, prepared by the reaction of aryl/alkyl amines with 2-bromoacetylbromide, in NaH/DMF to synthesize N-substituted-2-((5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-yl)sulfanyl)acetamide, 7a-f. The molecule 4 was stepped to ethyl ester and carbohydrazide. The carbohydrazide was made to react with aryl carboxaldehydes in methanol to synthesize N'-substituted-2-(5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-ylthio)acetohydrazide, 11a-i. The structures of all the molecules were corroborated through IR, ¹H-NMR and EI-MS spectral data. Both the series were screened for antibacterial and enzyme inhibition activity.
author	RASOOL,SHAHID AZIZ-UR-REHMAN, ABBASI,MUHAMMAD ATHAR SIDDIQUI,SABAHAT ZAHRA SHAH,SYED ADNAN ALI AHMAD,IRSHAD AFZAL,SAIRA
author_facet	RASOOL,SHAHID AZIZ-UR-REHMAN, ABBASI,MUHAMMAD ATHAR SIDDIQUI,SABAHAT ZAHRA SHAH,SYED ADNAN ALI AHMAD,IRSHAD AFZAL,SAIRA
author_sort	RASOOL,SHAHID
title	ANTIBACTERIAL AND ENZYME INHIBITION SCREENING OF SOME NEW ACETAMIDE AND AZOMETHINE DERIVATIVES
title_short	ANTIBACTERIAL AND ENZYME INHIBITION SCREENING OF SOME NEW ACETAMIDE AND AZOMETHINE DERIVATIVES
title_full	ANTIBACTERIAL AND ENZYME INHIBITION SCREENING OF SOME NEW ACETAMIDE AND AZOMETHINE DERIVATIVES
title_fullStr	ANTIBACTERIAL AND ENZYME INHIBITION SCREENING OF SOME NEW ACETAMIDE AND AZOMETHINE DERIVATIVES
title_full_unstemmed	ANTIBACTERIAL AND ENZYME INHIBITION SCREENING OF SOME NEW ACETAMIDE AND AZOMETHINE DERIVATIVES
title_sort	antibacterial and enzyme inhibition screening of some new acetamide and azomethine derivatives
publisher	Sociedad Chilena de Química
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000400014
work_keys_str_mv	AT rasoolshahid antibacterialandenzymeinhibitionscreeningofsomenewacetamideandazomethinederivatives AT azizurrehman antibacterialandenzymeinhibitionscreeningofsomenewacetamideandazomethinederivatives AT abbasimuhammadathar antibacterialandenzymeinhibitionscreeningofsomenewacetamideandazomethinederivatives AT siddiquisabahatzahra antibacterialandenzymeinhibitionscreeningofsomenewacetamideandazomethinederivatives AT shahsyedadnanali antibacterialandenzymeinhibitionscreeningofsomenewacetamideandazomethinederivatives AT ahmadirshad antibacterialandenzymeinhibitionscreeningofsomenewacetamideandazomethinederivatives AT afzalsaira antibacterialandenzymeinhibitionscreeningofsomenewacetamideandazomethinederivatives
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ANTIBACTERIAL AND ENZYME INHIBITION SCREENING OF SOME NEW ACETAMIDE AND AZOMETHINE DERIVATIVES

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