LIQUID CHROMATOGRAPHIC DETERMINATION OF SOLIFENACIN SUCCINATE, FLAVOXATE HYDROCHLORIDE AND TOLTERODINE TARTRATE IN BULK DRUGS AND THEIR PHARMACEUTICAL DOSAGE FORMS

A simple, precise, specific and accurate reversed phase HPLC (RP-HPLC) method has been developed for the determination of solifenacin succinate (SOLS), flavoxate HC1 (FLXHC) and toltoridine tartarate (TOLT) in bulk and pharmaceutical dosage forms. The proposed RP-HPLC method was carried out using Xt...

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Autores principales:	ATTIA,ALI K, FRAG,EMAN Y. Z, MOHAMED,GEHAD G, AHMED,HEBA E
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2016
Materias:	Solifenacin succinate Flavoxate HC1 Toltoridine tartarate RP-HPLC
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000100005
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spelling	oai:scielo:S0717-970720160001000052016-09-14LIQUID CHROMATOGRAPHIC DETERMINATION OF SOLIFENACIN SUCCINATE, FLAVOXATE HYDROCHLORIDE AND TOLTERODINE TARTRATE IN BULK DRUGS AND THEIR PHARMACEUTICAL DOSAGE FORMSATTIA,ALI KFRAG,EMAN Y. ZMOHAMED,GEHAD GAHMED,HEBA E Solifenacin succinate Flavoxate HC1 Toltoridine tartarate RP-HPLC A simple, precise, specific and accurate reversed phase HPLC (RP-HPLC) method has been developed for the determination of solifenacin succinate (SOLS), flavoxate HC1 (FLXHC) and toltoridine tartarate (TOLT) in bulk and pharmaceutical dosage forms. The proposed RP-HPLC method was carried out using XterraRP-18 column (5 μm practical size, 25 cm x 4.6 mm i.d.). The flow rate, the injection volume and the detection wavelength were 1.0 μL/min, 20 μL and 200 nm, respectively. The mobile phase consisted of 0.05 M pentane sulfonic acid sodium salt (SOLS: pH 3.0±0.05, FLXHC and TOLT: pH 5.5±0.05) and acetonitrile (50:50 v/v). The retention times for SOLS, FLXHC and TOLT drugs were found to be 4.1±0.1 min, 4.3±0.0 min and 5.8±0.1 min, respectively. The calibration was linear over the concentration range of 0.1-100 μg/μL. The mean recoveries for SOLS, FLXHC and TOLT drugs were about 99.80%, 100.43% and 100.00%, respectively. The method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.61 n.1 20162016-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000100005en10.4067/S0717-97072016000100005
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Solifenacin succinate Flavoxate HC1 Toltoridine tartarate RP-HPLC
spellingShingle	Solifenacin succinate Flavoxate HC1 Toltoridine tartarate RP-HPLC ATTIA,ALI K FRAG,EMAN Y. Z MOHAMED,GEHAD G AHMED,HEBA E LIQUID CHROMATOGRAPHIC DETERMINATION OF SOLIFENACIN SUCCINATE, FLAVOXATE HYDROCHLORIDE AND TOLTERODINE TARTRATE IN BULK DRUGS AND THEIR PHARMACEUTICAL DOSAGE FORMS
description	A simple, precise, specific and accurate reversed phase HPLC (RP-HPLC) method has been developed for the determination of solifenacin succinate (SOLS), flavoxate HC1 (FLXHC) and toltoridine tartarate (TOLT) in bulk and pharmaceutical dosage forms. The proposed RP-HPLC method was carried out using XterraRP-18 column (5 μm practical size, 25 cm x 4.6 mm i.d.). The flow rate, the injection volume and the detection wavelength were 1.0 μL/min, 20 μL and 200 nm, respectively. The mobile phase consisted of 0.05 M pentane sulfonic acid sodium salt (SOLS: pH 3.0±0.05, FLXHC and TOLT: pH 5.5±0.05) and acetonitrile (50:50 v/v). The retention times for SOLS, FLXHC and TOLT drugs were found to be 4.1±0.1 min, 4.3±0.0 min and 5.8±0.1 min, respectively. The calibration was linear over the concentration range of 0.1-100 μg/μL. The mean recoveries for SOLS, FLXHC and TOLT drugs were about 99.80%, 100.43% and 100.00%, respectively. The method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness.
author	ATTIA,ALI K FRAG,EMAN Y. Z MOHAMED,GEHAD G AHMED,HEBA E
author_facet	ATTIA,ALI K FRAG,EMAN Y. Z MOHAMED,GEHAD G AHMED,HEBA E
author_sort	ATTIA,ALI K
title	LIQUID CHROMATOGRAPHIC DETERMINATION OF SOLIFENACIN SUCCINATE, FLAVOXATE HYDROCHLORIDE AND TOLTERODINE TARTRATE IN BULK DRUGS AND THEIR PHARMACEUTICAL DOSAGE FORMS
title_short	LIQUID CHROMATOGRAPHIC DETERMINATION OF SOLIFENACIN SUCCINATE, FLAVOXATE HYDROCHLORIDE AND TOLTERODINE TARTRATE IN BULK DRUGS AND THEIR PHARMACEUTICAL DOSAGE FORMS
title_full	LIQUID CHROMATOGRAPHIC DETERMINATION OF SOLIFENACIN SUCCINATE, FLAVOXATE HYDROCHLORIDE AND TOLTERODINE TARTRATE IN BULK DRUGS AND THEIR PHARMACEUTICAL DOSAGE FORMS
title_fullStr	LIQUID CHROMATOGRAPHIC DETERMINATION OF SOLIFENACIN SUCCINATE, FLAVOXATE HYDROCHLORIDE AND TOLTERODINE TARTRATE IN BULK DRUGS AND THEIR PHARMACEUTICAL DOSAGE FORMS
title_full_unstemmed	LIQUID CHROMATOGRAPHIC DETERMINATION OF SOLIFENACIN SUCCINATE, FLAVOXATE HYDROCHLORIDE AND TOLTERODINE TARTRATE IN BULK DRUGS AND THEIR PHARMACEUTICAL DOSAGE FORMS
title_sort	liquid chromatographic determination of solifenacin succinate, flavoxate hydrochloride and tolterodine tartrate in bulk drugs and their pharmaceutical dosage forms
publisher	Sociedad Chilena de Química
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000100005
work_keys_str_mv	AT attiaalik liquidchromatographicdeterminationofsolifenacinsuccinateflavoxatehydrochlorideandtolterodinetartrateinbulkdrugsandtheirpharmaceuticaldosageforms AT fragemanyz liquidchromatographicdeterminationofsolifenacinsuccinateflavoxatehydrochlorideandtolterodinetartrateinbulkdrugsandtheirpharmaceuticaldosageforms AT mohamedgehadg liquidchromatographicdeterminationofsolifenacinsuccinateflavoxatehydrochlorideandtolterodinetartrateinbulkdrugsandtheirpharmaceuticaldosageforms AT ahmedhebae liquidchromatographicdeterminationofsolifenacinsuccinateflavoxatehydrochlorideandtolterodinetartrateinbulkdrugsandtheirpharmaceuticaldosageforms
_version_	1718445546484531200

LIQUID CHROMATOGRAPHIC DETERMINATION OF SOLIFENACIN SUCCINATE, FLAVOXATE HYDROCHLORIDE AND TOLTERODINE TARTRATE IN BULK DRUGS AND THEIR PHARMACEUTICAL DOSAGE FORMS

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