SENSITIVE SIMULTANEOUS DETERMINATION OF PARACETAMOL AND DICLOFENAC BASED ON Au NANOPARTICLES - FUNCTIONALIZED GRAPHENE/POLY (L-ARGININE) GLASSY CARBON ELECTRODE

A voltammetric sensor was proposed for simultaneous determination of paracetamol and diclofenac based on poly (L-arginine)/Au-graphene nanocomposite film deposited on a glassy carbon electrode. Cyclic voltammetry showed that paracetamol and diclofenac provided well - defined oxidation peaks at +0.44...

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Autores principales:	AFSHAR,ESMAIL, JALALI,FAHIMEH
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2016
Materias:	Paracetamol Diclofenac Arginine Au Graphene Modified electrode Voltammetry
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000100019
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spelling	oai:scielo:S0717-970720160001000192016-09-14SENSITIVE SIMULTANEOUS DETERMINATION OF PARACETAMOL AND DICLOFENAC BASED ON Au NANOPARTICLES - FUNCTIONALIZED GRAPHENE/POLY (L-ARGININE) GLASSY CARBON ELECTRODEAFSHAR,ESMAILJALALI,FAHIMEH Paracetamol Diclofenac Arginine Au Graphene Modified electrode Voltammetry A voltammetric sensor was proposed for simultaneous determination of paracetamol and diclofenac based on poly (L-arginine)/Au-graphene nanocomposite film deposited on a glassy carbon electrode. Cyclic voltammetry showed that paracetamol and diclofenac provided well - defined oxidation peaks at +0.443 and +0.644 V, respectively. Experimental parameters, such as the concentration of L-arginine and number of potential cycles in electro-polymerization step,accumulation potential and time, and the pH of buffer solution were optimized. Under the optimized conditions, linear relationships between oxidation peak current and concentration in the range 0.5 - 50.0 pM for paracetamol, and 0.5 - 40.0 pM for diclofenac were obtained in linear sweep voltammetry regime. The limits of detection (LOD) for paracetamol and diclofenac were 0.04 and 0.08 pM, respectively. The fabricated electrode exhibited good reproducibility and stability.The proposed method was successfully applied to the assessment of low concentrations of paracetamol and diclofenac in spiked human blood serum samples withsatisfactory results.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.61 n.1 20162016-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000100019en10.4067/S0717-97072016000100019
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Paracetamol Diclofenac Arginine Au Graphene Modified electrode Voltammetry
spellingShingle	Paracetamol Diclofenac Arginine Au Graphene Modified electrode Voltammetry AFSHAR,ESMAIL JALALI,FAHIMEH SENSITIVE SIMULTANEOUS DETERMINATION OF PARACETAMOL AND DICLOFENAC BASED ON Au NANOPARTICLES - FUNCTIONALIZED GRAPHENE/POLY (L-ARGININE) GLASSY CARBON ELECTRODE
description	A voltammetric sensor was proposed for simultaneous determination of paracetamol and diclofenac based on poly (L-arginine)/Au-graphene nanocomposite film deposited on a glassy carbon electrode. Cyclic voltammetry showed that paracetamol and diclofenac provided well - defined oxidation peaks at +0.443 and +0.644 V, respectively. Experimental parameters, such as the concentration of L-arginine and number of potential cycles in electro-polymerization step,accumulation potential and time, and the pH of buffer solution were optimized. Under the optimized conditions, linear relationships between oxidation peak current and concentration in the range 0.5 - 50.0 pM for paracetamol, and 0.5 - 40.0 pM for diclofenac were obtained in linear sweep voltammetry regime. The limits of detection (LOD) for paracetamol and diclofenac were 0.04 and 0.08 pM, respectively. The fabricated electrode exhibited good reproducibility and stability.The proposed method was successfully applied to the assessment of low concentrations of paracetamol and diclofenac in spiked human blood serum samples withsatisfactory results.
author	AFSHAR,ESMAIL JALALI,FAHIMEH
author_facet	AFSHAR,ESMAIL JALALI,FAHIMEH
author_sort	AFSHAR,ESMAIL
title	SENSITIVE SIMULTANEOUS DETERMINATION OF PARACETAMOL AND DICLOFENAC BASED ON Au NANOPARTICLES - FUNCTIONALIZED GRAPHENE/POLY (L-ARGININE) GLASSY CARBON ELECTRODE
title_short	SENSITIVE SIMULTANEOUS DETERMINATION OF PARACETAMOL AND DICLOFENAC BASED ON Au NANOPARTICLES - FUNCTIONALIZED GRAPHENE/POLY (L-ARGININE) GLASSY CARBON ELECTRODE
title_full	SENSITIVE SIMULTANEOUS DETERMINATION OF PARACETAMOL AND DICLOFENAC BASED ON Au NANOPARTICLES - FUNCTIONALIZED GRAPHENE/POLY (L-ARGININE) GLASSY CARBON ELECTRODE
title_fullStr	SENSITIVE SIMULTANEOUS DETERMINATION OF PARACETAMOL AND DICLOFENAC BASED ON Au NANOPARTICLES - FUNCTIONALIZED GRAPHENE/POLY (L-ARGININE) GLASSY CARBON ELECTRODE
title_full_unstemmed	SENSITIVE SIMULTANEOUS DETERMINATION OF PARACETAMOL AND DICLOFENAC BASED ON Au NANOPARTICLES - FUNCTIONALIZED GRAPHENE/POLY (L-ARGININE) GLASSY CARBON ELECTRODE
title_sort	sensitive simultaneous determination of paracetamol and diclofenac based on au nanoparticles - functionalized graphene/poly (l-arginine) glassy carbon electrode
publisher	Sociedad Chilena de Química
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000100019
work_keys_str_mv	AT afsharesmail sensitivesimultaneousdeterminationofparacetamolanddiclofenacbasedonaunanoparticlesfunctionalizedgraphenepolylarginineglassycarbonelectrode AT jalalifahimeh sensitivesimultaneousdeterminationofparacetamolanddiclofenacbasedonaunanoparticlesfunctionalizedgraphenepolylarginineglassycarbonelectrode
_version_	1718445549084999680

SENSITIVE SIMULTANEOUS DETERMINATION OF PARACETAMOL AND DICLOFENAC BASED ON Au NANOPARTICLES - FUNCTIONALIZED GRAPHENE/POLY (L-ARGININE) GLASSY CARBON ELECTRODE

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