SYNTHESIS AND STUDY ON MAGNETIC RESONANCE IMAGING PERFORMANCE OF GD(III)-DTPA-BISBENZOTHIAZOL HYDRAZIDE

In this paper, 2-hydrazino-6-methoxy-1,3-benzothiazole was introduced into diethylenetriamine pentaacetic (DTPA) by acylation reaction. The corresponding non-ion Gd(III) complex holding promise of a single molecule magnetic resonance imaging (MRI) contrast agent was obtained by treating this ligand...

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Autores principales:	WAN,FU-XIAN, ZHANG,TIAN-KAI, LI,YING, LI,CHANG-CHENG, JIANG,LIN
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2016
Materias:	MRI contrast agent benzothiazole DTPA derivative gadolinium complex relaxivity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000200003
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spelling	oai:scielo:S0717-970720160002000032016-09-14SYNTHESIS AND STUDY ON MAGNETIC RESONANCE IMAGING PERFORMANCE OF GD(III)-DTPA-BISBENZOTHIAZOL HYDRAZIDEWAN,FU-XIANZHANG,TIAN-KAILI,YINGLI,CHANG-CHENGJIANG,LIN MRI contrast agent benzothiazole DTPA derivative gadolinium complex relaxivity In this paper, 2-hydrazino-6-methoxy-1,3-benzothiazole was introduced into diethylenetriamine pentaacetic (DTPA) by acylation reaction. The corresponding non-ion Gd(III) complex holding promise of a single molecule magnetic resonance imaging (MRI) contrast agent was obtained by treating this ligand with GdCl3·6H2 O. The efficacy of the contrast agent was assessed by measuring the longitudinal relaxivity (r1), the r1 of Gd(III)-DTPA-bisbenzothiazole hydrazide was up to 6.44 mM-1,s-1, which was 1.8 times higher than that of the analogous MRI contrast agent Gd(III)-DTPA (r1 = 3.64 mM-1s-1) in commercial use. In addition, in vitro MR images on a 0.5 T magnetic field exhibited a remarkable enhancement of signal contrast for Gd(III)-DTPA-bisbenzothiazole hydrazide than Gd(III)-DTPA. These results demonstrate that this non-ion Gd(III) complex acts as a potentially MRI contrast agent.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.61 n.2 20162016-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000200003en10.4067/S0717-97072016000200003
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	MRI contrast agent benzothiazole DTPA derivative gadolinium complex relaxivity
spellingShingle	MRI contrast agent benzothiazole DTPA derivative gadolinium complex relaxivity WAN,FU-XIAN ZHANG,TIAN-KAI LI,YING LI,CHANG-CHENG JIANG,LIN SYNTHESIS AND STUDY ON MAGNETIC RESONANCE IMAGING PERFORMANCE OF GD(III)-DTPA-BISBENZOTHIAZOL HYDRAZIDE
description	In this paper, 2-hydrazino-6-methoxy-1,3-benzothiazole was introduced into diethylenetriamine pentaacetic (DTPA) by acylation reaction. The corresponding non-ion Gd(III) complex holding promise of a single molecule magnetic resonance imaging (MRI) contrast agent was obtained by treating this ligand with GdCl3·6H2 O. The efficacy of the contrast agent was assessed by measuring the longitudinal relaxivity (r1), the r1 of Gd(III)-DTPA-bisbenzothiazole hydrazide was up to 6.44 mM-1,s-1, which was 1.8 times higher than that of the analogous MRI contrast agent Gd(III)-DTPA (r1 = 3.64 mM-1s-1) in commercial use. In addition, in vitro MR images on a 0.5 T magnetic field exhibited a remarkable enhancement of signal contrast for Gd(III)-DTPA-bisbenzothiazole hydrazide than Gd(III)-DTPA. These results demonstrate that this non-ion Gd(III) complex acts as a potentially MRI contrast agent.
author	WAN,FU-XIAN ZHANG,TIAN-KAI LI,YING LI,CHANG-CHENG JIANG,LIN
author_facet	WAN,FU-XIAN ZHANG,TIAN-KAI LI,YING LI,CHANG-CHENG JIANG,LIN
author_sort	WAN,FU-XIAN
title	SYNTHESIS AND STUDY ON MAGNETIC RESONANCE IMAGING PERFORMANCE OF GD(III)-DTPA-BISBENZOTHIAZOL HYDRAZIDE
title_short	SYNTHESIS AND STUDY ON MAGNETIC RESONANCE IMAGING PERFORMANCE OF GD(III)-DTPA-BISBENZOTHIAZOL HYDRAZIDE
title_full	SYNTHESIS AND STUDY ON MAGNETIC RESONANCE IMAGING PERFORMANCE OF GD(III)-DTPA-BISBENZOTHIAZOL HYDRAZIDE
title_fullStr	SYNTHESIS AND STUDY ON MAGNETIC RESONANCE IMAGING PERFORMANCE OF GD(III)-DTPA-BISBENZOTHIAZOL HYDRAZIDE
title_full_unstemmed	SYNTHESIS AND STUDY ON MAGNETIC RESONANCE IMAGING PERFORMANCE OF GD(III)-DTPA-BISBENZOTHIAZOL HYDRAZIDE
title_sort	synthesis and study on magnetic resonance imaging performance of gd(iii)-dtpa-bisbenzothiazol hydrazide
publisher	Sociedad Chilena de Química
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000200003
work_keys_str_mv	AT wanfuxian synthesisandstudyonmagneticresonanceimagingperformanceofgdiiidtpabisbenzothiazolhydrazide AT zhangtiankai synthesisandstudyonmagneticresonanceimagingperformanceofgdiiidtpabisbenzothiazolhydrazide AT liying synthesisandstudyonmagneticresonanceimagingperformanceofgdiiidtpabisbenzothiazolhydrazide AT lichangcheng synthesisandstudyonmagneticresonanceimagingperformanceofgdiiidtpabisbenzothiazolhydrazide AT jianglin synthesisandstudyonmagneticresonanceimagingperformanceofgdiiidtpabisbenzothiazolhydrazide
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SYNTHESIS AND STUDY ON MAGNETIC RESONANCE IMAGING PERFORMANCE OF GD(III)-DTPA-BISBENZOTHIAZOL HYDRAZIDE

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