NEW SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF MIRTAZAPINE IN PHARMACEUTICAL FORMULATIONS

A simple extractive spectrophotometric method has been developed for the quantification of mirtazapine. This method is based on the formation of ion-association complex of mirtazapine drug with bromocresol purple dye. The absorbance of the complex was measured at 400 nm. The method was successfully...

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Autores principales:	REHMAN,FOZIA, GUL,SAIMA, HUSSAIN,SAJJAD, KHAN,SABIR
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2016
Materias:	Spectrophotometric ion-association pharmaceutical formulations
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000200013
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spelling	oai:scielo:S0717-970720160002000132016-09-14NEW SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF MIRTAZAPINE IN PHARMACEUTICAL FORMULATIONSREHMAN,FOZIAGUL,SAIMAHUSSAIN,SAJJADKHAN,SABIR Spectrophotometric ion-association pharmaceutical formulations A simple extractive spectrophotometric method has been developed for the quantification of mirtazapine. This method is based on the formation of ion-association complex of mirtazapine drug with bromocresol purple dye. The absorbance of the complex was measured at 400 nm. The method was successfully applied to the determination of mirtazapine in their pharmaceutical formulations. The method shows a linear range from 0.2-10 μg mL-1 with a molar absorptivity of 1.53 '10 4 L mol-1 cm-1. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.096 μg mL-1 and 0.32μg mL-1 respectively. The developed methodology was successfully applied for the determination of mirtazapine in commercial formulation and the percentage recovery was found 99.91 ± 0.15. The developed methodology promises a feasible, low cost and an efficient method for the routine analysis.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.61 n.2 20162016-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000200013en10.4067/S0717-97072016000200013
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Spectrophotometric ion-association pharmaceutical formulations
spellingShingle	Spectrophotometric ion-association pharmaceutical formulations REHMAN,FOZIA GUL,SAIMA HUSSAIN,SAJJAD KHAN,SABIR NEW SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF MIRTAZAPINE IN PHARMACEUTICAL FORMULATIONS
description	A simple extractive spectrophotometric method has been developed for the quantification of mirtazapine. This method is based on the formation of ion-association complex of mirtazapine drug with bromocresol purple dye. The absorbance of the complex was measured at 400 nm. The method was successfully applied to the determination of mirtazapine in their pharmaceutical formulations. The method shows a linear range from 0.2-10 μg mL-1 with a molar absorptivity of 1.53 '10 4 L mol-1 cm-1. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.096 μg mL-1 and 0.32μg mL-1 respectively. The developed methodology was successfully applied for the determination of mirtazapine in commercial formulation and the percentage recovery was found 99.91 ± 0.15. The developed methodology promises a feasible, low cost and an efficient method for the routine analysis.
author	REHMAN,FOZIA GUL,SAIMA HUSSAIN,SAJJAD KHAN,SABIR
author_facet	REHMAN,FOZIA GUL,SAIMA HUSSAIN,SAJJAD KHAN,SABIR
author_sort	REHMAN,FOZIA
title	NEW SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF MIRTAZAPINE IN PHARMACEUTICAL FORMULATIONS
title_short	NEW SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF MIRTAZAPINE IN PHARMACEUTICAL FORMULATIONS
title_full	NEW SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF MIRTAZAPINE IN PHARMACEUTICAL FORMULATIONS
title_fullStr	NEW SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF MIRTAZAPINE IN PHARMACEUTICAL FORMULATIONS
title_full_unstemmed	NEW SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF MIRTAZAPINE IN PHARMACEUTICAL FORMULATIONS
title_sort	new spectrophotometry method for the determination of mirtazapine in pharmaceutical formulations
publisher	Sociedad Chilena de Química
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000200013
work_keys_str_mv	AT rehmanfozia newspectrophotometrymethodforthedeterminationofmirtazapineinpharmaceuticalformulations AT gulsaima newspectrophotometrymethodforthedeterminationofmirtazapineinpharmaceuticalformulations AT hussainsajjad newspectrophotometrymethodforthedeterminationofmirtazapineinpharmaceuticalformulations AT khansabir newspectrophotometrymethodforthedeterminationofmirtazapineinpharmaceuticalformulations
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NEW SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF MIRTAZAPINE IN PHARMACEUTICAL FORMULATIONS

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