SYNTHESIS AND ANTIFUNGAL ACTIVITY OF DIARYL HYDRAZONES FROM 2,4-DINITROPHENYLHYDRAZINE

A new series of diarylhydrazones derived from 2,4-dinitrophenylhydrazine were synthesized via condensation with aromatic aldehydes whose structures have been determined by mass spectrometry, infrared spectroscopy, and nuclear magnetic resonance spectra. Yields were 50-99%. All compounds were screene...

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Autores principales:	ORTIZ,SERGIO, NELSON,RONALD, KESTERNICH,VÍCTOR, PÉREZ-FEHRMANN,MARCIA, CHRISTEN,PHILIPPE, MARCOURT,LAURENCE
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2016
Materias:	Antifungal Activity Diarylhydrazones Schiff bases
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000300015
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spelling	oai:scielo:S0717-970720160003000152017-06-14SYNTHESIS AND ANTIFUNGAL ACTIVITY OF DIARYL HYDRAZONES FROM 2,4-DINITROPHENYLHYDRAZINEORTIZ,SERGIONELSON,RONALDKESTERNICH,VÍCTORPÉREZ-FEHRMANN,MARCIACHRISTEN,PHILIPPEMARCOURT,LAURENCE Antifungal Activity Diarylhydrazones Schiff bases A new series of diarylhydrazones derived from 2,4-dinitrophenylhydrazine were synthesized via condensation with aromatic aldehydes whose structures have been determined by mass spectrometry, infrared spectroscopy, and nuclear magnetic resonance spectra. Yields were 50-99%. All compounds were screened in vitro for their antifungal activity. Preliminary results indicated that compounds 3g and 3h exhibited promising antifungal potency. Understanding of the structure of these compounds establishes a preliminary structure-activity relationship to form the basis of further investigation.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.61 n.3 20162016-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000300015en10.4067/S0717-97072016000300015
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Antifungal Activity Diarylhydrazones Schiff bases
spellingShingle	Antifungal Activity Diarylhydrazones Schiff bases ORTIZ,SERGIO NELSON,RONALD KESTERNICH,VÍCTOR PÉREZ-FEHRMANN,MARCIA CHRISTEN,PHILIPPE MARCOURT,LAURENCE SYNTHESIS AND ANTIFUNGAL ACTIVITY OF DIARYL HYDRAZONES FROM 2,4-DINITROPHENYLHYDRAZINE
description	A new series of diarylhydrazones derived from 2,4-dinitrophenylhydrazine were synthesized via condensation with aromatic aldehydes whose structures have been determined by mass spectrometry, infrared spectroscopy, and nuclear magnetic resonance spectra. Yields were 50-99%. All compounds were screened in vitro for their antifungal activity. Preliminary results indicated that compounds 3g and 3h exhibited promising antifungal potency. Understanding of the structure of these compounds establishes a preliminary structure-activity relationship to form the basis of further investigation.
author	ORTIZ,SERGIO NELSON,RONALD KESTERNICH,VÍCTOR PÉREZ-FEHRMANN,MARCIA CHRISTEN,PHILIPPE MARCOURT,LAURENCE
author_facet	ORTIZ,SERGIO NELSON,RONALD KESTERNICH,VÍCTOR PÉREZ-FEHRMANN,MARCIA CHRISTEN,PHILIPPE MARCOURT,LAURENCE
author_sort	ORTIZ,SERGIO
title	SYNTHESIS AND ANTIFUNGAL ACTIVITY OF DIARYL HYDRAZONES FROM 2,4-DINITROPHENYLHYDRAZINE
title_short	SYNTHESIS AND ANTIFUNGAL ACTIVITY OF DIARYL HYDRAZONES FROM 2,4-DINITROPHENYLHYDRAZINE
title_full	SYNTHESIS AND ANTIFUNGAL ACTIVITY OF DIARYL HYDRAZONES FROM 2,4-DINITROPHENYLHYDRAZINE
title_fullStr	SYNTHESIS AND ANTIFUNGAL ACTIVITY OF DIARYL HYDRAZONES FROM 2,4-DINITROPHENYLHYDRAZINE
title_full_unstemmed	SYNTHESIS AND ANTIFUNGAL ACTIVITY OF DIARYL HYDRAZONES FROM 2,4-DINITROPHENYLHYDRAZINE
title_sort	synthesis and antifungal activity of diaryl hydrazones from 2,4-dinitrophenylhydrazine
publisher	Sociedad Chilena de Química
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000300015
work_keys_str_mv	AT ortizsergio synthesisandantifungalactivityofdiarylhydrazonesfrom24dinitrophenylhydrazine AT nelsonronald synthesisandantifungalactivityofdiarylhydrazonesfrom24dinitrophenylhydrazine AT kesternichvictor synthesisandantifungalactivityofdiarylhydrazonesfrom24dinitrophenylhydrazine AT perezfehrmannmarcia synthesisandantifungalactivityofdiarylhydrazonesfrom24dinitrophenylhydrazine AT christenphilippe synthesisandantifungalactivityofdiarylhydrazonesfrom24dinitrophenylhydrazine AT marcourtlaurence synthesisandantifungalactivityofdiarylhydrazonesfrom24dinitrophenylhydrazine
_version_	1714200897071874048

SYNTHESIS AND ANTIFUNGAL ACTIVITY OF DIARYL HYDRAZONES FROM 2,4-DINITROPHENYLHYDRAZINE

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