DEVELOPMENT OF A KINETIC SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF CICLOPIROX OLAMINE IN PHARMACEUTICAL SAMPLE

A simple and sensitive kinetic spectrophotometric method was developed for the determination of ciclopirox olamine in pharmaceutical formulations (cream). The method is based on the oxidation of ciclopirox olamine with KMnO4 in alkaline medium to form K2MnO4, a bluish green color compound, at ionic...

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Autores principales:	NACARATTE,FALLON, TORAL,M. INÉS, SOTO,CÉSAR
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2016
Materias:	kinetic spectrophotometric ciclopirox olamine
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000300019
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spelling	oai:scielo:S0717-970720160003000192017-06-14DEVELOPMENT OF A KINETIC SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF CICLOPIROX OLAMINE IN PHARMACEUTICAL SAMPLENACARATTE,FALLONTORAL,M. INÉSSOTO,CÉSAR kinetic spectrophotometric ciclopirox olamine A simple and sensitive kinetic spectrophotometric method was developed for the determination of ciclopirox olamine in pharmaceutical formulations (cream). The method is based on the oxidation of ciclopirox olamine with KMnO4 in alkaline medium to form K2MnO4, a bluish green color compound, at ionic strength controlled and room temperature. The reaction is monitored measuring the rate of change of absorbance at 610 nm. The absorbance-concentration plot corresponding to synthetic pharmaceutical samples (cream) was rectilinear, over the range of 0.32 - 10.0 μg mL-1, with detection and quantification limits of 0.095 μg mL¹ and 0.32 μg mL¹, respectively. Different experimental parameters affecting the development and stability of the reaction product were carefully studied via factorial screening and optimized by univariate method. The determination of ciclopirox olamine by the fixed time method is feasible and more advantageous with the calibration equation obtained at 30 min. The proposed method was validated for the application of the determination of the drug in pharmaceutical sample (cream).info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.61 n.3 20162016-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000300019en10.4067/S0717-97072016000300019
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	kinetic spectrophotometric ciclopirox olamine
spellingShingle	kinetic spectrophotometric ciclopirox olamine NACARATTE,FALLON TORAL,M. INÉS SOTO,CÉSAR DEVELOPMENT OF A KINETIC SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF CICLOPIROX OLAMINE IN PHARMACEUTICAL SAMPLE
description	A simple and sensitive kinetic spectrophotometric method was developed for the determination of ciclopirox olamine in pharmaceutical formulations (cream). The method is based on the oxidation of ciclopirox olamine with KMnO4 in alkaline medium to form K2MnO4, a bluish green color compound, at ionic strength controlled and room temperature. The reaction is monitored measuring the rate of change of absorbance at 610 nm. The absorbance-concentration plot corresponding to synthetic pharmaceutical samples (cream) was rectilinear, over the range of 0.32 - 10.0 μg mL-1, with detection and quantification limits of 0.095 μg mL¹ and 0.32 μg mL¹, respectively. Different experimental parameters affecting the development and stability of the reaction product were carefully studied via factorial screening and optimized by univariate method. The determination of ciclopirox olamine by the fixed time method is feasible and more advantageous with the calibration equation obtained at 30 min. The proposed method was validated for the application of the determination of the drug in pharmaceutical sample (cream).
author	NACARATTE,FALLON TORAL,M. INÉS SOTO,CÉSAR
author_facet	NACARATTE,FALLON TORAL,M. INÉS SOTO,CÉSAR
author_sort	NACARATTE,FALLON
title	DEVELOPMENT OF A KINETIC SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF CICLOPIROX OLAMINE IN PHARMACEUTICAL SAMPLE
title_short	DEVELOPMENT OF A KINETIC SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF CICLOPIROX OLAMINE IN PHARMACEUTICAL SAMPLE
title_full	DEVELOPMENT OF A KINETIC SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF CICLOPIROX OLAMINE IN PHARMACEUTICAL SAMPLE
title_fullStr	DEVELOPMENT OF A KINETIC SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF CICLOPIROX OLAMINE IN PHARMACEUTICAL SAMPLE
title_full_unstemmed	DEVELOPMENT OF A KINETIC SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF CICLOPIROX OLAMINE IN PHARMACEUTICAL SAMPLE
title_sort	development of a kinetic spectrophotometry method for the determination of ciclopirox olamine in pharmaceutical sample
publisher	Sociedad Chilena de Química
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000300019
work_keys_str_mv	AT nacarattefallon developmentofakineticspectrophotometrymethodforthedeterminationofciclopiroxolamineinpharmaceuticalsample AT toralmines developmentofakineticspectrophotometrymethodforthedeterminationofciclopiroxolamineinpharmaceuticalsample AT sotocesar developmentofakineticspectrophotometrymethodforthedeterminationofciclopiroxolamineinpharmaceuticalsample
_version_	1714200897748205568

DEVELOPMENT OF A KINETIC SPECTROPHOTOMETRY METHOD FOR THE DETERMINATION OF CICLOPIROX OLAMINE IN PHARMACEUTICAL SAMPLE

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