SOLID PHASE EXTRACTION AND LC-MS/MS METHOD FOR QUANTIFICATION OF VENLAFAXINE AND ITS ACTIVE METABOLITE O-DESMETHYL VENLAFAXINE IN RAT PLASMA

SOLID PHASE EXTRACTION AND LC-MS/MS METHOD FOR QUANTIFICATION OF VENLAFAXINE AND ITS ACTIVE METABOLITE O-DESMETHYL VENLAFAXINE IN RAT PLASMA

A rapid, simple, sensitive LC-MS/MS method involving a least pretreatment process has been proposed for the quantitative assessment of venlafaxine (VEN) and O-desmethyl venlafaxine (ODV) using cetirizine as an internal standard. The method was validated over the range of 1.03 ng/mL to 453.50 ng/mL (...

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Autores principales: AHMAD,SARFARAZ, SIDDIQUI,MASOOM R, ALI,MD. S, WABAIDUR,SAIKH M, ALAM,MD. S, ALAM,NAWAZISH, ALOTHMAN,ZEID A, KHAN,MOONIS ALI, KHAN,MOHAMMAD R
Lenguaje:English
Publicado: Sociedad Chilena de Química 2016
Materias:
venlafaxine
o-desmethyl venlafaxine
pharmacokinetics
solid phase extraction
LC-MS/MS
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000300025
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