CHANGES IN SECONDARY METABOLITES PROFILES AND BIOLOGICAL ACTIVITY OF THE FRESH FRUITING BODIES OF Stereum hirsutum EXPOSED TO HIGH-DOSE UV-B RADIATION

The present study aims to investigate the effects of ultraviolet radiation (type B) on the steroid and fatty acids content, phenolic compounds and biological activities of Stereum hirsutum wild fruiting bodies, which has been used by both Chinese and Korean folk medicine to treat cancer and recently...

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Autores principales:	TORRES,SOLANGE, CABRERA-PARDO,JAIMER, ALONSO,FELIPE, BUSTOS,EVELYN, PÉREZ,CLAUDIA, PALFNER,GOETZ, HERNÁNDEZ,VÍCTOR, URIARTE,EUGENIO, BECERRA,JOSÉ
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2016
Materias:	saprophytic fungi UV-B radiation antibacterial properties antioxidant activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000400015
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spelling	oai:scielo:S0717-970720160004000152017-01-16CHANGES IN SECONDARY METABOLITES PROFILES AND BIOLOGICAL ACTIVITY OF THE FRESH FRUITING BODIES OF Stereum hirsutum EXPOSED TO HIGH-DOSE UV-B RADIATIONTORRES,SOLANGECABRERA-PARDO,JAIMERALONSO,FELIPEBUSTOS,EVELYNPÉREZ,CLAUDIAPALFNER,GOETZHERNÁNDEZ,VÍCTORURIARTE,EUGENIOBECERRA,JOSÉ saprophytic fungi UV-B radiation antibacterial properties antioxidant activity The present study aims to investigate the effects of ultraviolet radiation (type B) on the steroid and fatty acids content, phenolic compounds and biological activities of Stereum hirsutum wild fruiting bodies, which has been used by both Chinese and Korean folk medicine to treat cancer and recently as functional food. From another perspective, the distribution of steroid derivatives as well as fatty acids underwent significant changes after UV exposure over time. In our model of study UV-B radiation induced a decrease in the relative abundance of ergosterol derivatives while squalene increased. We also detected that UVB radiation (1.2 W m-2) enhanced the antioxidant activity of Stereum hirsutum, with the acetonic extract after 48 hours of radiation the most efficient with a half-maximal inhibitory concentration (IC50) of 339.9 μg/mL. Gas-mass chromatography (GC-MS) analysis at this 48 hours stage revealed a high content of phenolic compounds (70%). We observed a decrease in the antibacterial activity against Escherichia coli, Salmonella typhi and Salmonella typhimurium compared to their respective controls. The study concludes that UV-B influences the pathway of secondary metabolites to induce changes metabolic in the composition of sterols and fatty acids and increasing the abundance of antioxidant compounds in S. hirsutum.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.61 n.4 20162016-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000400015en10.4067/S0717-97072016000400015
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	saprophytic fungi UV-B radiation antibacterial properties antioxidant activity
spellingShingle	saprophytic fungi UV-B radiation antibacterial properties antioxidant activity TORRES,SOLANGE CABRERA-PARDO,JAIMER ALONSO,FELIPE BUSTOS,EVELYN PÉREZ,CLAUDIA PALFNER,GOETZ HERNÁNDEZ,VÍCTOR URIARTE,EUGENIO BECERRA,JOSÉ CHANGES IN SECONDARY METABOLITES PROFILES AND BIOLOGICAL ACTIVITY OF THE FRESH FRUITING BODIES OF Stereum hirsutum EXPOSED TO HIGH-DOSE UV-B RADIATION
description	The present study aims to investigate the effects of ultraviolet radiation (type B) on the steroid and fatty acids content, phenolic compounds and biological activities of Stereum hirsutum wild fruiting bodies, which has been used by both Chinese and Korean folk medicine to treat cancer and recently as functional food. From another perspective, the distribution of steroid derivatives as well as fatty acids underwent significant changes after UV exposure over time. In our model of study UV-B radiation induced a decrease in the relative abundance of ergosterol derivatives while squalene increased. We also detected that UVB radiation (1.2 W m-2) enhanced the antioxidant activity of Stereum hirsutum, with the acetonic extract after 48 hours of radiation the most efficient with a half-maximal inhibitory concentration (IC50) of 339.9 μg/mL. Gas-mass chromatography (GC-MS) analysis at this 48 hours stage revealed a high content of phenolic compounds (70%). We observed a decrease in the antibacterial activity against Escherichia coli, Salmonella typhi and Salmonella typhimurium compared to their respective controls. The study concludes that UV-B influences the pathway of secondary metabolites to induce changes metabolic in the composition of sterols and fatty acids and increasing the abundance of antioxidant compounds in S. hirsutum.
author	TORRES,SOLANGE CABRERA-PARDO,JAIMER ALONSO,FELIPE BUSTOS,EVELYN PÉREZ,CLAUDIA PALFNER,GOETZ HERNÁNDEZ,VÍCTOR URIARTE,EUGENIO BECERRA,JOSÉ
author_facet	TORRES,SOLANGE CABRERA-PARDO,JAIMER ALONSO,FELIPE BUSTOS,EVELYN PÉREZ,CLAUDIA PALFNER,GOETZ HERNÁNDEZ,VÍCTOR URIARTE,EUGENIO BECERRA,JOSÉ
author_sort	TORRES,SOLANGE
title	CHANGES IN SECONDARY METABOLITES PROFILES AND BIOLOGICAL ACTIVITY OF THE FRESH FRUITING BODIES OF Stereum hirsutum EXPOSED TO HIGH-DOSE UV-B RADIATION
title_short	CHANGES IN SECONDARY METABOLITES PROFILES AND BIOLOGICAL ACTIVITY OF THE FRESH FRUITING BODIES OF Stereum hirsutum EXPOSED TO HIGH-DOSE UV-B RADIATION
title_full	CHANGES IN SECONDARY METABOLITES PROFILES AND BIOLOGICAL ACTIVITY OF THE FRESH FRUITING BODIES OF Stereum hirsutum EXPOSED TO HIGH-DOSE UV-B RADIATION
title_fullStr	CHANGES IN SECONDARY METABOLITES PROFILES AND BIOLOGICAL ACTIVITY OF THE FRESH FRUITING BODIES OF Stereum hirsutum EXPOSED TO HIGH-DOSE UV-B RADIATION
title_full_unstemmed	CHANGES IN SECONDARY METABOLITES PROFILES AND BIOLOGICAL ACTIVITY OF THE FRESH FRUITING BODIES OF Stereum hirsutum EXPOSED TO HIGH-DOSE UV-B RADIATION
title_sort	changes in secondary metabolites profiles and biological activity of the fresh fruiting bodies of stereum hirsutum exposed to high-dose uv-b radiation
publisher	Sociedad Chilena de Química
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000400015
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CHANGES IN SECONDARY METABOLITES PROFILES AND BIOLOGICAL ACTIVITY OF THE FRESH FRUITING BODIES OF Stereum hirsutum EXPOSED TO HIGH-DOSE UV-B RADIATION

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