NEW APPROACH FOR DETERMINATION OF FLUMEQUINE AND OXOLINIC ACID IN AQUEOUS SAMPLES BYIONIC LIQUID-BASED DISPERSIVE LIQUID-LIQUID MICROEXTRACTION AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-FLUORESCENCE DETECTION
A rapid and sensitive analytical method for the determination of oxolinic acid and flumequine in aqueous samples based on dispersive liquid-liquid microextraction using ionic liquids (ILs) was developed. Based on the structural properties of the antibiotic agents studied, two ILs with different func...
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Sociedad Chilena de Química
2016
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| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000400022 |
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oai:scielo:S0717-970720160004000222017-01-16NEW APPROACH FOR DETERMINATION OF FLUMEQUINE AND OXOLINIC ACID IN AQUEOUS SAMPLES BYIONIC LIQUID-BASED DISPERSIVE LIQUID-LIQUID MICROEXTRACTION AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-FLUORESCENCE DETECTIONTOLEDO-NEIRA,CARLABRAVO,MANUEL AÁLVAREZ-LUEJE,ALEJANDROA rapid and sensitive analytical method for the determination of oxolinic acid and flumequine in aqueous samples based on dispersive liquid-liquid microextraction using ionic liquids (ILs) was developed. Based on the structural properties of the antibiotic agents studied, two ILs with different functionalities were required: ethyl-dimethyl-(2-methoxyethyl) ammonium tris(pentafluoroethyl)trifluorophosphate ([MOEDEA][FAP]) for extraction and 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BFJ) to adjust the polarity of the medium. The significant experimental factors involved in DLLME were identified and optimized using the experimental design methodology. A Plackett-Burman design was initially used for screening, and a central composite design was used for optimization. The optimized method exhibited good precision, with relative standard deviation values of less than 5 % and limits of detections on the order of 0.1 and 0.3 ng mL-1 for the two drugs. The enrichment factors for both antibiotics were 13-33 fold. The proposed method was applied to the analysis of the two antibiotic in spiked surface, river, and wastewater samples.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.61 n.4 20162016-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000400022en10.4067/S0717-97072016000400022 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| description |
A rapid and sensitive analytical method for the determination of oxolinic acid and flumequine in aqueous samples based on dispersive liquid-liquid microextraction using ionic liquids (ILs) was developed. Based on the structural properties of the antibiotic agents studied, two ILs with different functionalities were required: ethyl-dimethyl-(2-methoxyethyl) ammonium tris(pentafluoroethyl)trifluorophosphate ([MOEDEA][FAP]) for extraction and 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BFJ) to adjust the polarity of the medium. The significant experimental factors involved in DLLME were identified and optimized using the experimental design methodology. A Plackett-Burman design was initially used for screening, and a central composite design was used for optimization. The optimized method exhibited good precision, with relative standard deviation values of less than 5 % and limits of detections on the order of 0.1 and 0.3 ng mL-1 for the two drugs. The enrichment factors for both antibiotics were 13-33 fold. The proposed method was applied to the analysis of the two antibiotic in spiked surface, river, and wastewater samples. |
| author |
TOLEDO-NEIRA,CARLA BRAVO,MANUEL A ÁLVAREZ-LUEJE,ALEJANDRO |
| spellingShingle |
TOLEDO-NEIRA,CARLA BRAVO,MANUEL A ÁLVAREZ-LUEJE,ALEJANDRO NEW APPROACH FOR DETERMINATION OF FLUMEQUINE AND OXOLINIC ACID IN AQUEOUS SAMPLES BYIONIC LIQUID-BASED DISPERSIVE LIQUID-LIQUID MICROEXTRACTION AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-FLUORESCENCE DETECTION |
| author_facet |
TOLEDO-NEIRA,CARLA BRAVO,MANUEL A ÁLVAREZ-LUEJE,ALEJANDRO |
| author_sort |
TOLEDO-NEIRA,CARLA |
| title |
NEW APPROACH FOR DETERMINATION OF FLUMEQUINE AND OXOLINIC ACID IN AQUEOUS SAMPLES BYIONIC LIQUID-BASED DISPERSIVE LIQUID-LIQUID MICROEXTRACTION AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-FLUORESCENCE DETECTION |
| title_short |
NEW APPROACH FOR DETERMINATION OF FLUMEQUINE AND OXOLINIC ACID IN AQUEOUS SAMPLES BYIONIC LIQUID-BASED DISPERSIVE LIQUID-LIQUID MICROEXTRACTION AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-FLUORESCENCE DETECTION |
| title_full |
NEW APPROACH FOR DETERMINATION OF FLUMEQUINE AND OXOLINIC ACID IN AQUEOUS SAMPLES BYIONIC LIQUID-BASED DISPERSIVE LIQUID-LIQUID MICROEXTRACTION AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-FLUORESCENCE DETECTION |
| title_fullStr |
NEW APPROACH FOR DETERMINATION OF FLUMEQUINE AND OXOLINIC ACID IN AQUEOUS SAMPLES BYIONIC LIQUID-BASED DISPERSIVE LIQUID-LIQUID MICROEXTRACTION AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-FLUORESCENCE DETECTION |
| title_full_unstemmed |
NEW APPROACH FOR DETERMINATION OF FLUMEQUINE AND OXOLINIC ACID IN AQUEOUS SAMPLES BYIONIC LIQUID-BASED DISPERSIVE LIQUID-LIQUID MICROEXTRACTION AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-FLUORESCENCE DETECTION |
| title_sort |
new approach for determination of flumequine and oxolinic acid in aqueous samples byionic liquid-based dispersive liquid-liquid microextraction and high-performance liquid chromatography-fluorescence detection |
| publisher |
Sociedad Chilena de Química |
| publishDate |
2016 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000400022 |
| work_keys_str_mv |
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| _version_ |
1714200903370670080 |