SYNTHESIS, QUALITY CONTROL AND BIODISTRIBUTION OF TECHNEIUM-99M TRIAMCINOLONE ACETONIDE (99mTc-TA) COMPLEX: AN INFLAMMATION TRACER AGENT

In present study synthesis of 99mTc-triamcinolone acetonide (99mTc-TA) complex and its stability using set of quality control parameters such as ligand concentration, reducing agent concentration, pH, temperature and reaction time was assessed. 99mTc-TA complex was characterized in terms of percent...

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Autores principales:	RIZVI,FAHEEM ASKARI, RAZA NAQVI,SYED ALI, MEHDI,MUHAMMAD, ROOHI,SAMINA, ZAHOOR,AMEER FAWAD, KHAN,ZULFIQAR ALI, SOHAIB,MUHAMMAD, RASHEED,RASHID
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2017
Materias:	99mTc-Triamcinolone Electrophoresis Biodistribution study Scintigraphy of Rabbits Serum Stability
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000100008
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spelling	oai:scielo:S0717-970720170001000082017-05-05SYNTHESIS, QUALITY CONTROL AND BIODISTRIBUTION OF TECHNEIUM-99M TRIAMCINOLONE ACETONIDE (99mTc-TA) COMPLEX: AN INFLAMMATION TRACER AGENTRIZVI,FAHEEM ASKARIRAZA NAQVI,SYED ALIMEHDI,MUHAMMADROOHI,SAMINAZAHOOR,AMEER FAWADKHAN,ZULFIQAR ALISOHAIB,MUHAMMADRASHEED,RASHID 99mTc-Triamcinolone Electrophoresis Biodistribution study Scintigraphy of Rabbits Serum Stability In present study synthesis of 99mTc-triamcinolone acetonide (99mTc-TA) complex and its stability using set of quality control parameters such as ligand concentration, reducing agent concentration, pH, temperature and reaction time was assessed. 99mTc-TA complex was characterized in terms of percent (%) yield, stability in saline and serum using chromatographic procedures. Radiochemically the 99mTc-TA complex was found quite stable in saline and serum. After 30 min of reaction the complex showed maximum radiochemical yield of 96.32% which decreased to 96.25 % after 4 h incubation period. In serum, the % yield of radiochemical was remained same up to 2 h which decreased to 93.5% at 24 h time point. Normal biodistribution pattern in Sprague-Dawley rats revealed liver, stomach and kidneys as areas of high 99mTc-TA complex uptake (8.44 ± 1.32, 8.75 ± 1.03 and 12.67 ± 1.21%, respectively) at 1 h post injection time point. Scintigraphy of 99mTc-TA in rabbits showed similar eco as observed in biodistribution study. Based on the promising results obtained in context of in vitro and in vivo stability and biodistribution, 99mTc-TA complex could be further studied to identify the inflammation based diseases.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.62 n.1 20172017-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000100008en10.4067/S0717-97072017000100008
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	99mTc-Triamcinolone Electrophoresis Biodistribution study Scintigraphy of Rabbits Serum Stability
spellingShingle	99mTc-Triamcinolone Electrophoresis Biodistribution study Scintigraphy of Rabbits Serum Stability RIZVI,FAHEEM ASKARI RAZA NAQVI,SYED ALI MEHDI,MUHAMMAD ROOHI,SAMINA ZAHOOR,AMEER FAWAD KHAN,ZULFIQAR ALI SOHAIB,MUHAMMAD RASHEED,RASHID SYNTHESIS, QUALITY CONTROL AND BIODISTRIBUTION OF TECHNEIUM-99M TRIAMCINOLONE ACETONIDE (99mTc-TA) COMPLEX: AN INFLAMMATION TRACER AGENT
description	In present study synthesis of 99mTc-triamcinolone acetonide (99mTc-TA) complex and its stability using set of quality control parameters such as ligand concentration, reducing agent concentration, pH, temperature and reaction time was assessed. 99mTc-TA complex was characterized in terms of percent (%) yield, stability in saline and serum using chromatographic procedures. Radiochemically the 99mTc-TA complex was found quite stable in saline and serum. After 30 min of reaction the complex showed maximum radiochemical yield of 96.32% which decreased to 96.25 % after 4 h incubation period. In serum, the % yield of radiochemical was remained same up to 2 h which decreased to 93.5% at 24 h time point. Normal biodistribution pattern in Sprague-Dawley rats revealed liver, stomach and kidneys as areas of high 99mTc-TA complex uptake (8.44 ± 1.32, 8.75 ± 1.03 and 12.67 ± 1.21%, respectively) at 1 h post injection time point. Scintigraphy of 99mTc-TA in rabbits showed similar eco as observed in biodistribution study. Based on the promising results obtained in context of in vitro and in vivo stability and biodistribution, 99mTc-TA complex could be further studied to identify the inflammation based diseases.
author	RIZVI,FAHEEM ASKARI RAZA NAQVI,SYED ALI MEHDI,MUHAMMAD ROOHI,SAMINA ZAHOOR,AMEER FAWAD KHAN,ZULFIQAR ALI SOHAIB,MUHAMMAD RASHEED,RASHID
author_facet	RIZVI,FAHEEM ASKARI RAZA NAQVI,SYED ALI MEHDI,MUHAMMAD ROOHI,SAMINA ZAHOOR,AMEER FAWAD KHAN,ZULFIQAR ALI SOHAIB,MUHAMMAD RASHEED,RASHID
author_sort	RIZVI,FAHEEM ASKARI
title	SYNTHESIS, QUALITY CONTROL AND BIODISTRIBUTION OF TECHNEIUM-99M TRIAMCINOLONE ACETONIDE (99mTc-TA) COMPLEX: AN INFLAMMATION TRACER AGENT
title_short	SYNTHESIS, QUALITY CONTROL AND BIODISTRIBUTION OF TECHNEIUM-99M TRIAMCINOLONE ACETONIDE (99mTc-TA) COMPLEX: AN INFLAMMATION TRACER AGENT
title_full	SYNTHESIS, QUALITY CONTROL AND BIODISTRIBUTION OF TECHNEIUM-99M TRIAMCINOLONE ACETONIDE (99mTc-TA) COMPLEX: AN INFLAMMATION TRACER AGENT
title_fullStr	SYNTHESIS, QUALITY CONTROL AND BIODISTRIBUTION OF TECHNEIUM-99M TRIAMCINOLONE ACETONIDE (99mTc-TA) COMPLEX: AN INFLAMMATION TRACER AGENT
title_full_unstemmed	SYNTHESIS, QUALITY CONTROL AND BIODISTRIBUTION OF TECHNEIUM-99M TRIAMCINOLONE ACETONIDE (99mTc-TA) COMPLEX: AN INFLAMMATION TRACER AGENT
title_sort	synthesis, quality control and biodistribution of techneium-99m triamcinolone acetonide (99mtc-ta) complex: an inflammation tracer agent
publisher	Sociedad Chilena de Química
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000100008
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SYNTHESIS, QUALITY CONTROL AND BIODISTRIBUTION OF TECHNEIUM-99M TRIAMCINOLONE ACETONIDE (99mTc-TA) COMPLEX: AN INFLAMMATION TRACER AGENT

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